DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Scn8a and NaCP60E

DIOPT Version :9

Sequence 1:XP_017172001.1 Gene:Scn8a / 20273 MGIID:103169 Length:1988 Species:Mus musculus
Sequence 2:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster


Alignment Length:2676 Identity:821/2676 - (30%)
Similarity:1170/2676 - (43%) Gaps:899/2676 - (33%)


- Green bases have known domain annotations that are detailed below.


Mouse    53 PKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLN---RGKTLFRFSATPALYI 114
            |:..:.:|.|..||..:...|:.:...|||:.|. ::.::||.|::   |...:.||:.|.:|::
  Fly    45 PRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFL 108

Mouse   115 LSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPEWSKNVEYTFTGIYTFESLVKIIA 179
            ..|::..||:.:.|..:..|...:|.|||.||:|:..:   |..:..||.|..||:.|.::||||
  Fly   109 FYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIA 170

Mouse   180 RGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 244
            :||.::.:|:||:|||||||.||...|.|..:::||::.||||||||||||:|::||||||:.||
  Fly   171 KGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINAL 235

Mouse   245 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCV-----VWPINFNESYLENGTRGFDWEE 304
            :.|.::|::||.||:|||.||||..||::||.||||||     .|.   |.|:.       ||:.
  Fly   236 LHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWT---NVSHT-------DWQI 290

Mouse   305 YINNKTNFYMVPGMLEPLLCGNSSDAGQCPEGFQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQ 369
            ::|:..|:......| |:||||.:.|..||..:.|:..|.|||:|||:||.|.|:.|..|:|:|.
  Fly   291 WVNDTDNWLYDEDEL-PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITL 354

Mouse   370 DYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAE------QK 428
            |||||:|.:.|...|...:.||.:|:|.|||||:||:|||||::|||:.:.|.||.:      :.
  Fly   355 DYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRD 419

Mouse   429 EAEF---------KAMLEQLKKQQEEAQAAAMA-----------TSAGTVSEDAIEEEGEDGVGS 473
            ::.|         |.:.:..||:.:..:...:|           |..|       :|.|.:|.|:
  Fly   420 DSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGG-------KEGGTNGNGN 477

Mouse   474 PRSSSELSKLSS---------KSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAF 529
            ..:..:....|:         .||.||.:....:.||:..:.|::   .|:.||.| .|......
  Fly   478 GSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQ---HKLAKSGS-GGSNNPMA 538

Mouse   530 RLPDNRIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEES 594
            ..|..||.     ...|.:.:.....|...:.|..:.:..|.......|...|.:.|:...|::.
  Fly   539 PTPKGRIS-----FQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDH 598

Mouse   595 E--------GRRDSLFIPIRARERRSSYSGYSGYSQCSRSSRIFPSLRRSVKRNSTVDCNGVVSL 651
            |        |...::.:.:..||.|                              .:.|||.::.
  Fly   599 EEQDTTNDMGHVSTVELALSPREVR------------------------------LIKCNGNIAR 633

Mouse   652 IGPGSHIGRLLPEVKIDKAATDSATTEVEIKKKGPGSLLVSMEQLASYGRKDRINSIMSVVTNTL 716
            | ...::..|..|.          ::||                                   .:
  Fly   634 I-KNHNVYALHQEF----------SSEV-----------------------------------VV 652

Mouse   717 VEELEESQRKCPPCWYKFANTFLIWECHPY--WIKLKEIVNLIVMDPFVDLAITICIVLNTLFMA 779
            :::|.:  |.|..|.:        | |..|  |::.:..:..:|.||..:||||:||||||.|:|
  Fly   653 IDDLPD--RNCDRCVH--------W-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLA 706

Mouse   780 MEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELGLAD 844
            ||||.|:..|.:.|.|||.|||.|||.|..:||:|:.. .:|..||||||..||:.||:::....
  Fly   707 MEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFEL 770

Mouse   845 VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 909
            |:||||||..|||||.|||:||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|
  Fly   771 VDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDY 835

Mouse   910 KECVCKISQECKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQAMCLIVFMMVMVI 971
            ..  .|...: .:|||:.|||||||:::||:|||||||.:||||   |..|.:.|..:|:..:|:
  Fly   836 TP--EKFDPD-PVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVM 897

Mouse   972 GNLVVLNLFLALLLSSFSADNLAATDDD-GEMNNLQISVIRI----------------------- 1012
            ||.:||||||||||:||:::.|.:..:: ||.:.|..|:.|:                       
  Fly   898 GNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKF 962

Mouse  1013 ---------------------------KKGVAWAKVKVHAF------------------------ 1026
                                       |.||. |:.|.|..                        
  Fly   963 QQIVLDAQQAHAQTLSHQAAVGLERGDKPGVL-AETKFHRLSYQESMNRPVSGSDFGFQIPLHDG 1026

Mouse  1027 ---------------------MQAHFKQREADEVKPLDELYEKKANCIANHTGVDIHRNGDFQK- 1069
                                 :|||.....:|.:.|   .||   :.:...||      |.|.. 
  Fly  1027 LHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPP---TYE---SAMMATTG------GSFSSV 1079

Mouse  1070 NGNGT---------------------------------------------------------TSG 1077
            |||||                                                         .||
  Fly  1080 NGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSG 1144

Mouse  1078 IGS----------SVEKYIIDEDHMSFIN-NPNLTVRVP-------------------------- 1105
            .||          |..:|..:|...:|:. ..:|..|.|                          
  Fly  1145 CGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEA 1209

Mouse  1106 ----------------------------------------------------------------- 1105
                                                                             
  Fly  1210 EMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRS 1274

Mouse  1106 -------------IAVGESDFENL------NTEDV-----------SSESDPEGSKD-------- 1132
                         ..|..|:|:|:      ..|::           |:.|:|..:.|        
  Fly  1275 RRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIME 1339

Mouse  1133 -----------------------------------------------------------KLDD-- 1136
                                                                       |:|:  
  Fly  1340 HIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDF 1404

Mouse  1137 ---------------------------TSSSEG----------------------STIDIKPEVE 1152
                                       ||:|:.                      ..:.:...||
  Fly  1405 SISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVE 1469

Mouse  1153 EVP-------------------------------------------------------------- 1155
            |||                                                              
  Fly  1470 EVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATP 1534

Mouse  1156 ----------------------------------------------------------------- 1155
                                                                             
  Fly  1535 PTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRR 1599

Mouse  1156 -VEQPEEYLD------------------------------------------------------- 1164
             :|.|:..||                                                       
  Fly  1600 RMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEK 1664

Mouse  1165 -----------------------------------------PDACFTEGCVQR--FKC-----CQ 1181
                                                     ||.||.:.|...  |:|     | 
  Fly  1665 PWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSC- 1728

Mouse  1182 VNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKV 1246
              ::....|.|..:|.....:|:...||.|::.:|..||..|.||||.:::.||::.:|.:.:..
  Fly  1729 --MDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFS 1791

Mouse  1247 FTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRP 1311
            |..||::||:|||.|.||.|:||:.|..|||:||.||:.||:...  ...|..::||||||||||
  Fly  1792 FCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRP 1854

Mouse  1312 LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEID 1376
            |||:||::|||:|||||:.|||||.|||||||:||||||||||..|.||:..|.||..|: ..|.
  Fly  1855 LRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGEL-LPIT 1918

Mouse  1377 EVNNKTDCEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPD 1441
            |||:|.||   :|.|.|   |.|.||.||:||.|||||||||||:|||::|..|||:|..|.||.
  Fly  1919 EVNDKWDC---IEQNYT---WINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQ 1977

Mouse  1442 YEGNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG--QDIFMTEEQKKYYNAMKKLG 1504
            .|.|:|.||||||||:.||||||||||||||||||..|||:.|  .::|:||.||.||.||||||
  Fly  1978 REANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLG 2042

Mouse  1505 SKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVF 1569
            .|||||.|.||:|....:.:|....:.|:|.|.:||.|||:||.:|...|...:..||...|..|
  Fly  2043 RKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFF 2107

Mouse  1570 VIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGR 1634
            ...|..|.::|:..||::|||:.||:|||::|:.||.|:.:.||:....:||||.||:|:.||||
  Fly  2108 TTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGR 2172

Mouse  1635 ILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETF 1699
            ||||||.|||||.|||||::|||||||||.||.|:.||::|.|||.|..||.:..:|||.||:||
  Fly  2173 ILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTF 2237

Mouse  1700 GNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLI 1764
            |.||..||::.|||||:.:|..::.:||||  |....|. ..|:||:|.:.|.:|.|:||||::|
  Fly  2238 GRSMQLLFRLMTSAGWNDVLESLMIQPPDC--DPFIHGH-TNGNCGHPLLAITYFTSFIIISYMI 2299

Mouse  1765 VVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRV 1829
            |:|||||||||||:.|.:|....:.|||.|.||..|.|:||.|||||.:.:|:||..:|:.||.:
  Fly  2300 VINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGI 2364

Mouse  1830 PKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELD---ILRQQMEERFVASNPSKVSY 1891
            .|||.:.|::.:||:..|::|||||||.|..|.|||...|.|   .|::||:.:|....|::...
  Fly  2365 SKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKEL 2429

Mouse  1892 EPITTTLRRKQEEVSAVVLQRAYRGHL-------------------------------------- 1918
            |.:::|...|::|.:|..:|..::.:|                                      
  Fly  2430 EIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQV 2494

Mouse  1919 ARRGFIC-RKITSNKLENGGTHREKKESTPSTASLP-----SYDSVTKPDKEKQQRAEEGRR--- 1974
            :|||..| .:.:|.|........:..|......:||     ..|.|.|  ..|||..|.|:|   
  Fly  2495 SRRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVK--DIKQQNDELGKRGSI 2557

Mouse  1975 ----ERAKRQK 1981
                .||.|::
  Fly  2558 FVEAPRASRRR 2568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Scn8aXP_017172001.1 Ion_trans 131..421 CDD:366146 140/294 (48%)
Na_trans_cytopl 504..710 CDD:371806 30/213 (14%)
Ion_trans 760..973 CDD:366146 116/215 (54%)
Na_trans_assoc 999..1200 CDD:368948 72/835 (9%)
Ion_trans 1205..1481 CDD:366146 161/275 (59%)
Na_channel_gate 1473..1525 CDD:240441 30/53 (57%)
Ion_trans 1530..1784 CDD:366146 132/253 (52%)
GPHH 1796..1843 CDD:374878 21/46 (46%)
IQ 1902..1923 CDD:197470 6/58 (10%)
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 112/229 (49%)
Ion_trans 705..902 CDD:278921 105/200 (53%)
Ion_trans 1768..2019 CDD:278921 157/259 (61%)
Na_channel_gate 2009..2063 CDD:240441 30/53 (57%)
Ion_trans 2085..2320 CDD:278921 124/237 (52%)
GPHH 2331..2386 CDD:293510 24/54 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.750

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