DRSC/TRiP Functional Genomics Resources

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Protein Alignment Scn7a and NaCP60E

DIOPT Version :9

Sequence 1:NP_033161.2 Gene:Scn7a / 20272 MGIID:102965 Length:1681 Species:Mus musculus
Sequence 2:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster


Alignment Length:2518 Identity:616/2518 - (24%)
Similarity:975/2518 - (38%) Gaps:908/2518 - (36%)


- Green bases have known domain annotations that are detailed below.


Mouse    10 LVPFTTESLELIEN-HIAKKCNEDPEEEEGLKP--SRNLEAGKRLPIPYGTLPRGTVSEPLEDVD 71
            :|.:|..|....|| ||      ....|.|..|  ..::|.|..||..:...|.....:|||::|
  Fly    19 VVAYTQRSQVKHENRHI------QLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLEEID 77

Mouse    72 PYYYVKRNTFMVLN---RSRVIFRFNAVSIFCTLSPLNSLRRAAIKALVHPLFRLLILISVLTDS 133
            .:.|  ..||.|::   |...|.||..........|.:..||..:....:..|...::.::|.:.
  Fly    78 TFIY--EETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNC 140

Mouse   134 ILMCMSNLPEWILAIENTLLGIYAFEILVKVIARGIWAGSFSFLGDLWNWLDFSVTLFELITRFS 198
            |.:.|:   |.:...|...|.||:.|:::|:||:|.....:::|.:.||||||.|......|...
  Fly   141 IFLAMT---ETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGM 202

Mouse   199 PLSSFLMLKTIRTFRILKIIPLNHGLQSIVMTLAQCLKKLFGAIALALFFLAVFSLLGMGLFMGN 263
            .:.:...|:|.|..|.||.:.:..||::|:..|....::|...:.|.:|.|.||:|..:.::||.
  Fly   203 EVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGE 267

Mouse   264 LKHKCLRWPEENENETLH-------NRTGSLNYSPERINFYYMEGAKYALLCGNRTDAGQCPEGY 321
            |::||:|....:.....|       |.|.:..|..:.:          .:||||.|.|..||..|
  Fly   268 LRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDEL----------PVLCGNLTGARHCPFEY 322

Mouse   322 VCVKEGTNPDNGFTSFDNFGWSLLAMFRLMTQDYPELLYHQILYASGKVYMIFFVMISFWFAFYL 386
            ||:..|.||::|:|:||||.||:|..|:|:|.||.|.:|:.:|...|.:.:.||.::.|:.:|||
  Fly   323 VCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYL 387

Mouse   387 TSLFLGILTMTYEKEKQRACEE------------SGGLDPKCQQTVKELDEEND----------- 428
            .:|.|.::.::||:|.:...||            :...||.. ..||:|::.|.           
  Fly   388 INLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSV-LNVKKLNKNNKKKIDSRKGVLL 451

Mouse   429 -----------------------------------------------------------AAEMET 434
                                                                       .|:.:.
  Fly   452 ASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQY 516

Mouse   435 TQIEMKKR-------------SPT------------------------------------SINTT 450
            .|:|.:.:             :||                                    |.|::
  Fly   517 QQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSS 581

Mouse   451 -------------LDILE--DTT--LGHREEPETS------------------------------ 468
                         :|..|  |||  :||....|.:                              
  Fly   582 GVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEF 646

Mouse   469 -----------RKKCPICWHKFIKTCFIWKCS--PCWVKLNEFADRVITHPLADLFLVICIVLNI 520
                       .:.|..|.|        | |:  ..|::......:|:..||.:|.:.:|||||.
  Fly   647 SSEVVVIDDLPDRNCDRCVH--------W-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNT 702

Mouse   521 CFLALEHFPMSEELRSLLHVGNLVFIGIYTIEMILKIIAMHPYGYFQISWNIFDSILVVLELTEI 585
            .|||:||..|||..|:.|.|||.||..|:|.|.|:|::|:.. .:|...|||||.::|...|.:|
  Fly   703 AFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDI 766

Mouse   586 LLADVEGLAVLITVPLI-FIKLGKYGPPFKSLMRILGSSLMALKDLVLLLCIFVYFSAVFGMKLF 649
            :...|:||:||..:.|: .:||.:.....|.|:.|:.|::.||.:|.|:|.|.:|..||.||:||
  Fly   767 IFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLF 831

Mouse   650 GRSYKDCVCHIKEDCQP-QRWHMSDFLHAYMTVFRILCGEWIETLWECM---EVAGQAWCIPFYM 710
            .:.|..    .|.|..| .||:.:||.|::|.:||||||||||.||:||   |..|.:.|...::
  Fly   832 SKDYTP----EKFDPDPVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFL 892

Mouse   711 MVILIGNLLILYLFVT-LVSSFSYYDATS---EVNKEAK-------------------------- 745
            ..:::||.::|.||:. |::||:..:..|   ||.:|:|                          
  Fly   893 PTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERK 957

Mouse   746 ---------------------------------------------NLQLAMAR------------ 753
                                                         :.|.:|.|            
  Fly   958 FAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIP 1022

Mouse   754 ----------------------------------------------------------------- 753
                                                                             
  Fly  1023 LHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQN 1087

Mouse   754 --------------IKSGINSM------------LLKLMCTERSVPTE--ATDQI--C------- 781
                          |.||:::.            .::|:....|..|:  |.||.  |       
  Fly  1088 LTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGD 1152

Mouse   782 -----------------------------DPSVKENI--------------------------SG 791
                                         .||.::::                          ||
  Fly  1153 SLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSG 1217

Mouse   792 HTLSELSNTQ-----------------------TFLRYKDQSSSTEK------------------ 815
            .:|:.:|..|                       .||:.:::.....|                  
  Fly  1218 QSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMG 1282

Mouse   816 -----TPVTESESQSLI--------------------------ASPSASET-------VPIASGE 842
                 |.|..||..::|                          .||:|.|.       :.|.:|.
  Fly  1283 QPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGA 1347

Mouse   843 S---------------DIENLDNKETRSKSGNGGSKE---KMKQSSSSECSTVD----------- 878
            |               |..:|.:...||:|.:..::.   |:|:.|..:...:|           
  Fly  1348 SERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRK 1412

Mouse   879 -------------------------------------------------IAISEEEEMVYEHEK- 893
                                                             :::.|..|.|.|.|| 
  Fly  1413 ICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKP 1477

Mouse   894 -------------SKLH--------------KNGYER------------------------KSS- 906
                         ..||              .|.||.                        ||| 
  Fly  1478 ISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSI 1542

Mouse   907 ----------------------------------------------------TGQISR------- 912
                                                                .||..|       
  Fly  1543 EPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQST 1607

Mouse   913 ----------------------------------------------------------------- 912
                                                                             
  Fly  1608 LDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSY 1672

Mouse   913 ---------------------------------------------------------ESRNGKIW 920
                                                                     ::::.|.|
  Fly  1673 VDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHW 1737

Mouse   921 KNIRKTCCKIVENSWFECFIGLVTLLCTGTLALEDIYIDQRKTTKILLEYADMIFAYIFILEMLL 985
            ..:|.....:|:...||.|:.::....:.||..|||.:|:.||.|.:|.:.:..|..||::||:|
  Fly  1738 TRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMIL 1802

Mouse   986 KWVAYGFKAFFSNNWYKLDFMVVIVFCLSLIGKTREDLNPLTSIKFLRA---LRVLSQFERMKVV 1047
            ||:|.||..:|::.|..|||::|.|...||:.:..|:|..|.|::.|||   ||.:|:::.|::|
  Fly  1803 KWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIV 1867

Mouse  1048 LRALIKTTLPTVSVFLVCLMIWLLFSVIGVQLFAGKFYECIDPTKGERFPVFEVMNKSQCEKLLF 1112
            :.||:.......:|.||||:.||:||::|||.|.|||::|:: ..||..|:.||.:|..|    .
  Fly  1868 VNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN-EMGELLPITEVNDKWDC----I 1927

Mouse  1113 NESMPWENAKLNFDNVGNGFLSLLQVATFNGWISIMNSAIDSVGVNMQPSFEYNLYMYSYFIIFV 1177
            .::..|.|:|:.||:||.|:|:|||||||.||:.:|..|:|:.||::||..|.|||.|.||:||:
  Fly  1928 EQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFI 1992

Mouse  1178 IFGLFLPLCMLIGVIIRNFN--KQKIKQGGSNIFITVKQKKQYRALKKLLYADVQKPTPRPRNKF 1240
            :.|.|..|.:.|||||.|||  |:|.:.|...:|:|..||..|.|:|||.....||...||.|.|
  Fly  1993 VCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHF 2057

Mouse  1241 QGFLFDLVTHRVFNVIIILLICFQATTIMIQKDEQSPQMETAIFWM----NSIFVMLFTLECILK 1301
            ....:||...|.|.:.|.:||.....|:.|:..:| |.   |:|::    |:.|..:|.||.|:|
  Fly  2058 LAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQ-PH---AVFFILEVSNAFFTTVFGLEAIVK 2118

Mouse  1302 LTAFRCHYFTSAWNVHDFMVVIFSITGLLLPLTIGQYFVPPSLVQLILLSRVIHILRPGKGPKVF 1366
            :...|.||||..|||.||::|:.||.|:|:...:....:.|:|::::.:.|:..|||..|..|..
  Fly  2119 IVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGI 2183

Mouse  1367 HDLMLPLILALPALLNISLLIFLVMFIYAIFGMYNFAYVKKEAGINDVSNFETFGSSMLCLFQVT 1431
            ..|:..|:::||||.||..|:.|:.|||||.||..|..||.:..::|:.||:|||.||..||::.
  Fly  2184 RKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLM 2248

Mouse  1432 TFSGWDGMLDAIFNSQWSDCDPDKINPGTQVKGDCGSPSVGISYFVSYILISWLIIVNMYIVLIM 1496
            |.:||:.:|:::. .|..|||| .|:..|  .|:||.|.:.|:||.|:|:||::|::||||.:|:
  Fly  2249 TSAGWNDVLESLM-IQPPDCDP-FIHGHT--NGNCGHPLLAITYFTSFIIISYMIVINMYIAIIL 2309

Mouse  1497 EFLSIPSQKKSRTLSEDDFRRFFRVWNRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLVA 1561
            |..:...|::...:.|||...|:..|:::||..||:|..|:||||.|:|||||.::|||...||:
  Fly  2310 ENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVS 2374

Mouse  1562 MDLPMAAGDRIHCLDILLAFTKRVMGKDERVE---KILSEIESGFMLANPFKITYEPITTTLKRK 1623
            .:||::.|::|||||||.|..|.|:|..|..:   ::..:::..|....|.:...|.:::|...|
  Fly  2375 FNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWK 2439

Mouse  1624 QEAVSATIIQRAYKSYRLRQNDKNVSDTPAIDDRRDDLTSKGAHSGKI 1671
            ::..:|..||..:|.|..|:.:|..|::   .|.....:|.|....|:
  Fly  2440 RQEKAAKTIQTGWKEYLRRKREKERSNS---GDSATQTSSPGGWQSKL 2484

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Scn7aNP_033161.2 Ion_trans 140..405 CDD:278921 89/271 (33%)
Ion_trans 523..739 CDD:278921 90/224 (40%)
Na_trans_assoc 743..927 CDD:284034 66/814 (8%)
Ion_trans 951..1204 CDD:278921 114/257 (44%)
Na_channel_gate 1195..1246 CDD:240441 21/52 (40%)
Ion_trans 1275..1497 CDD:278921 92/225 (41%)
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 77/228 (34%)
Ion_trans 705..902 CDD:278921 83/201 (41%)
Ion_trans 1768..2019 CDD:278921 114/255 (45%)
Na_channel_gate 2009..2063 CDD:240441 21/53 (40%)
Ion_trans 2085..2320 CDD:278921 95/242 (39%)
GPHH 2331..2386 CDD:293510 26/54 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.720

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