DRSC/TRiP Functional Genomics Resources

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Protein Alignment Scn3a and NaCP60E

DIOPT Version :9

Sequence 1:NP_001342095.1 Gene:Scn3a / 20269 MGIID:98249 Length:1996 Species:Mus musculus
Sequence 2:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster


Alignment Length:2607 Identity:820/2607 - (31%)
Similarity:1187/2607 - (45%) Gaps:845/2607 - (32%)


- Green bases have known domain annotations that are detailed below.


Mouse    26 EKRAAEEKAKKPKKEQDIDDENK-----------PKPNSDLEAGKNLPFIYGDIPPEMVSEPLED 79
            ||..|:.:.....:...:..||:           |:..:.:|.|..||..:...|..|..:|||:
  Fly    11 EKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLEE 75

Mouse    80 LDPYYVSKKTFVVLNK---GKAIFRFSATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTN 141
            :|. ::.::||.|::|   ...|.||:.|.:|::..|.:|.|::.:.|..:..|...:|.|||.|
  Fly    76 IDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFN 139

Mouse   142 CVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEF 206
            |:|:.::   :..:..||.|..||:.|.:|||:|:||.|..:|:||:|||||||.||...|.|..
  Fly   140 CIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIG 201

Mouse   207 VDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            :::||::.||||||||||||:|::||||||:.||:.|.::|::||.||:|||.||||..||::||
  Fly   202 MEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMG 266

Mouse   272 NLRNKCLQWPPSDSAFEINTTSYFNGTMDSNGTFVNVTMSTFNWKDYIADDSHFYVLDGQKDPLL 336
            .|||||::..|:|                    :.||  |..:|:.:: :|:..::.|..:.|:|
  Fly   267 ELRNKCVRQVPTD--------------------WTNV--SHTDWQIWV-NDTDNWLYDEDELPVL 308

Mouse   337 CGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYM 401
            |||.:.|..||..|:|:..|.|||:|||:||.|.|:.|:.|:|:|.|||||:|.:.|...|...:
  Fly   309 CGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSV 373

Mouse   402 IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAE------QKEAEF---------QQMLEQ 451
            .||.:|:|.|||||:||:|||||::|||:.:.|.||.:      :.::.|         :::.:.
  Fly   374 SFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKN 438

Mouse   452 LKKQQEEAQAVAAASAASR---------------DFSGIGGLGELLESSSEASKLSSKSAKEWRN 501
            .||:.:..:.|..||.:.:               :.:|.|..|:..:|.| |:.....|.:....
  Fly   439 NKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHS-ATPSPGPSPRHSAT 502

Mouse   502 RR------KKRRQREHLEGNHR----------------PEGDRFPKSESEDSVKRRSFLFSLDGN 544
            .|      :.::|.:.:|..|:                |:| |....:|...||..:.|:..|  
  Fly   503 ERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKG-RISFQDSGMGVKNPNMLYPSD-- 564

Mouse   545 PLSGDKKLCSPHQSLLSIRGSLFS----PRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFEDSE 605
                             .:|.|.:    |..||.             |...:.:.|:....:|.|
  Fly   565 -----------------YKGQLIANSGQPSSNSS-------------GVNRESSQDDSGVVDDHE 599

Mouse   606 SRRDSLFVPHRPGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGPSALTSPTGQL 670
            .:..:..:.|       .:..:.::|.|.|          ..:.|||.::               
  Fly   600 EQDTTNDMGH-------VSTVELALSPREV----------RLIKCNGNIA--------------- 632

Mouse   671 PPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAMSIASILTNTMEELEESRQKCPPCWYRFAN 735
                       |.:..:.|.:..|...:              ...:::|.:  :.|..|.:    
  Fly   633 -----------RIKNHNVYALHQEFSSE--------------VVVIDDLPD--RNCDRCVH---- 666

Mouse   736 VFLIWDCCD--SWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLV 798
                | |.|  |||:.::.:..:|.||..:||||:||||||.|:||||:.|:|.|.:.|.|||.|
  Fly   667 ----W-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKV 726

Mouse   799 FTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAK 863
            ||.|||.|.::|::|:.. .:|..||||||.:||:.||:::....|:||||||..|||||.|||:
  Fly   727 FTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQ 790

Mouse   864 SWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINEDCKLPRWHMND 928
            ||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|..  .|.:.| .:|||:.||
  Fly   791 SWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPRWNFND 852

Mouse   929 FFHSFLIVFRVLCGEWIETMWDCM---EVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSD 990
            |||||:::||:|||||||.:||||   |..|.:.|..:|:..:|:||.:||||||||||:||:|:
  Fly   853 FFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSE 917

Mouse   991 NLAATDDD-NEMNNLQIAVGRM--------QKGIDYVKNKIRECFRKAFF--------------- 1031
            .|.:..:: .|.:.|..::.|:        |:..|..:.|..|.|::...               
  Fly   918 ELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAA 982

Mouse  1032 ------RKPKV---------------------------IEIHEG--NKIDSCMSNNTGVV--EIS 1059
                  .||.|                           |.:|:|  ..:|....::||.:  :|.
  Fly   983 VGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQ 1047

Mouse  1060 KELNYLK-------------------------DGNGT------------------TSGVGT---- 1077
            .:.:.|.                         :||||                  :|||.|    
  Fly  1048 LQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYD 1112

Mouse  1078 ----------------------------------------------------------------- 1077
                                                                             
  Fly  1113 SREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKS 1177

Mouse  1078 ---------------------------------------GSSVEKYVIDENDYMSFINN------ 1097
                                                   |.|:....|::::.:|...|      
  Fly  1178 LLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELL 1242

Mouse  1098 ----------------------------------PSLTVTVP---IAVGESDFENLNTEEFSSES 1125
                                              ||..:..|   ..|..|:|:|:..   |.|.
  Fly  1243 NCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQ---SFEK 1304

Mouse  1126 ELEESKEKLNA-----------------------------TSSSEGSTVD--VAP---------- 1149
            ||||.|....:                             |.:||.|..|  |.|          
  Fly  1305 ELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLS 1369

Mouse  1150 --PREG----------------------------------------------------------- 1153
              ||..                                                           
  Fly  1370 SVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSA 1434

Mouse  1154 -------------------------------EQAEIEPEED------------------------ 1163
                                           |:.|..|||:                        
  Fly  1435 SQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQL 1499

Mouse  1164 -----------------------------------------------------LK---------- 1165
                                                                 ||          
  Fly  1500 RLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTE 1564

Mouse  1166 ----------------------------------------------------------------- 1165
                                                                             
  Fly  1565 HQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADA 1629

Mouse  1166 ----------------------------------------------------------------- 1165
                                                                             
  Fly  1630 SSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTF 1694

Mouse  1166 -----------PEACFTEGCIKKF----PFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVF 1215
                       |:.||.:.|...|    |:.....:....|.|..:|....::|:...||.|::.
  Fly  1695 PSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLV 1759

Mouse  1216 MILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLI 1280
            :|..||..|.||||.:::.||:|.:|.:.:..|..||::||:|||:|.||..|||:.|..|||:|
  Fly  1760 LIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFII 1824

Mouse  1281 VDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLI 1345
            |.||:.||:...  ...|..::|||||||||||||:||::|||:|||||:.|||||.|||||||:
  Fly  1825 VFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLV 1887

Mouse  1346 FWLIFSIMGVNLFAGKFYHCVNMTTGSMFDMSEVNNFSDCQALGKQARWKNVKVNFDNVGAGYLA 1410
            ||||||||||..|.|||:.||| ..|.:..::|||:..||  :.:...|.|.|:.||:||.||||
  Fly  1888 FWLIFSIMGVQFFGGKFFKCVN-EMGELLPITEVNDKWDC--IEQNYTWINSKITFDHVGMGYLA 1949

Mouse  1411 LLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1475
            |||||||:|||::|..|||:|.|.|||..|.|||.|:||||||:.||||||||||||||||||..
  Fly  1950 LLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNML 2014

Mouse  1476 KKKFGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILIC 1538
            |||:.|  .::|:||.||.||.||||||.|||||.|.||.|.|..|.:|....:.|:|:|.:||.
  Fly  2015 KKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIF 2079

Mouse  1539 LNMVTMMVETDDQSKYMTLVLSRINLVFIVLFTGEFLLKLISLRYYYFTIGWNIFDFVVVILSIV 1603
            |||:||.:|..||...:..:|...|..|..:|..|.::|::.|||:|||:.||:|||::|:.||.
  Fly  2080 LNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIF 2144

Mouse  1604 GMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1668
            |:.:.:::....:||||.||:|:.||||||||||.|||||.|||||::|||||||||.||.|:.|
  Fly  2145 GILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITF 2209

Mouse  1669 IYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDAIH 1733
            ||||.|||.|..||.:..:|||.||:|||.||..||::.|||||:.:|..:: ..|||||| .||
  Fly  2210 IYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLM-IQPPDCDP-FIH 2272

Mouse  1734 PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVW 1798
              ....|:||:|.:.|.:|.|:||||:::|:|||||:|||||:.|.:|....:.|||.||||..|
  Fly  2273 --GHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRW 2335

Mouse  1799 EKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLG 1863
            .|:||.|||||.|.:||||.|:|||||.|:|||.|.|::.:||:..|::|||||||.|..|.|||
  Fly  2336 SKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLG 2400

Mouse  1864 ESGEMD---ALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNYRCYLLKQRLKNIS 1925
            ...|.|   .|:.||:.:|....|::...|.:::|...|::|.:|..||..::.||.::|.|..|
  Fly  2401 HVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERS 2465

Mouse  1926 NTYDKET 1932
            |:.|..|
  Fly  2466 NSGDSAT 2472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Scn3aNP_001342095.1 Ion_trans 127..434 CDD:306908 140/306 (46%)
Na_trans_cytopl 510..697 CDD:314757 29/206 (14%)
Ion_trans 759..972 CDD:306908 116/215 (54%)
Na_trans_assoc 998..1201 CDD:310839 71/822 (9%)
Ion_trans 1206..1478 CDD:306908 158/271 (58%)
Na_channel_gate 1470..1522 CDD:240441 32/53 (60%)
Ion_trans 1526..1782 CDD:306908 133/255 (52%)
GPHH 1786..1849 CDD:318993 36/62 (58%)
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 113/241 (47%)
Ion_trans 705..902 CDD:278921 105/200 (53%)
Ion_trans 1768..2019 CDD:278921 154/255 (60%)
Na_channel_gate 2009..2063 CDD:240441 32/53 (60%)
Ion_trans 2085..2320 CDD:278921 125/238 (53%)
GPHH 2331..2386 CDD:293510 31/54 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.720

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