DRSC/TRiP Functional Genomics Resources

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Protein Alignment Scn1a and NaCP60E

DIOPT Version :9

Sequence 1:NP_001300926.1 Gene:Scn1a / 20265 MGIID:98246 Length:2009 Species:Mus musculus
Sequence 2:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster


Alignment Length:2555 Identity:814/2555 - (31%)
Similarity:1175/2555 - (45%) Gaps:798/2555 - (31%)


- Green bases have known domain annotations that are detailed below.


Mouse    49 PKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNK---GKAIFRFSATSALYI 110
            |:..:.:|.|..||..:...|..|..:|||::|. :|.::||.|::|   ...|.||:.|.:|::
  Fly    45 PRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFL 108

Mouse   111 LTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIA 175
            ..|::|.|::.:.|..:..|...:|.|||.||:|:.|:   :..:..||.|..||:.|.:|||||
  Fly   109 FYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIA 170

Mouse   176 RGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240
            :||.|..:|:||:|||||||.|||..|.|..:::||::.||||||||||||:|::||||||:.||
  Fly   171 KGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINAL 235

Mouse   241 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVQWPPTNASLEEHSIEKNITMDYNGTLV 305
            :.|.::|::||.||:|||.||||..||::||.||||||:..||:.:...|:              
  Fly   236 LHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHT-------------- 286

Mouse   306 NETVFEFDWKSYIQDSRYHYFLEGVLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSW 370
                   ||:.::.|:....:.|..| .:||||.:.|..||..|:|:..|.|||:|||:||.|.|
  Fly   287 -------DWQIWVNDTDNWLYDEDEL-PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMW 343

Mouse   371 AFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLE 435
            :.|:.|:|:|.|:|||:|.:.|...|...:.||.:|:|.||||||||:|||||::|||:.:.|.|
  Fly   344 SMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNE 408

Mouse   436 EAEQKEAEFQQMLEQLKKQQEAAQQAAATTASEHSREPSAAGRLSDSSSEASKLSSK------SA 494
            |.::         :.|..:.:          |..|.:||.......:.:...|:.|:      |.
  Fly   409 ERKK---------DLLDHRDD----------STFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASY 454

Mouse   495 KERRNRRKKRKQKEQSG------GEEKDDDEFHKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPH 553
            .:::.||||.|..::.|      |...||::.|.:.                         .||.
  Fly   455 SKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSAT-------------------------PSPG 494

Mouse   554 QSLLSIRGSLFSPRRNS--RTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGE 616
            .          |||.::  |.|..:.:.:     .:....:.:|...:......::...|...|.
  Fly   495 P----------SPRHSATERPSALTMQAQ-----KQYQQMEQQHKLAKSGSGGSNNPMAPTPKGR 544

Mouse   617 RRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDN 681
            ....:.....::..||  :|::.|       ..:::..|.||..:|.|.:        :.:.||:
  Fly   545 ISFQDSGMGVKNPNML--YPSDYK-------GQLIANSGQPSSNSSGVNR--------ESSQDDS 592

Mouse   682 GTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAM----SIASILTNTVEELEES------------ 730
            |...:.|.:...:...|||...|....:..|.:    :||.|..:.|..|.:.            
  Fly   593 GVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLP 657

Mouse   731 RQKCPPCWYKFSNIFLIWDCSPY--WLKVKHIVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMT 793
            .:.|..|.:        | |:.|  ||:.::.:..||.||..:||||:||||||.|:||||:.|:
  Fly   658 DRNCDRCVH--------W-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMS 713

Mouse   794 EHFNHVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVL 858
            |.|.:.|.|||.|||.|||.|..:|::|:.. .:|..||||||..|||.||:::....|:|||||
  Fly   714 ESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVL 777

Mouse   859 RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKI 923
            |..|||||.|||:||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|..  .|.
  Fly   778 RGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKF 840

Mouse   924 ATDCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQAMCLTVFMMVMVIGNLVVLN 985
            ..| .:|||:.|||||||:::||:|||||||.:||||   |..|.:.|..:|:..:|:||.:|||
  Fly   841 DPD-PVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLN 904

Mouse   986 LFLALLLSSFSADNLAATDDD-NEMNNLQIAVDRMHKGIAYVK--------RKIYEFIQQSFVKK 1041
            |||||||:||:::.|.:..:: .|.:.|..:::|:...|...:        ||..|..||..:..
  Fly   905 LFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDA 969

Mouse  1042 QK---------------------ILDEIK-----------------------PLDD--------- 1053
            |:                     :|.|.|                       ||.|         
  Fly   970 QQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGL 1034

Mouse  1054 --------------------------------------------LN------------------- 1055
                                                        :|                   
  Fly  1035 EYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQ 1099

Mouse  1056 -------------------------------------------------NRKDNCISNHTTEIG- 1070
                                                             ||.|:...|.:...| 
  Fly  1100 HQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGS 1164

Mouse  1071 ----------------------KDLDCLKDVNGTTSGI------------GTGSSVEKYIIDESD 1101
                                  |.||.|...:|.:...            .:|.|:....|::.:
  Fly  1165 EEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDE 1229

Mouse  1102 YMSFINN----------------------------------------PSLTVTVP---IAVGESD 1123
            .:|...|                                        ||..:..|   ..|..|:
  Fly  1230 LLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSE 1294

Mouse  1124 FENLNTEDFSSE--------SDLEESKEKLNESSSSSEGSTVDI--------GA----------- 1161
            |:|: .:.|..|        :.||.....|:|.|.:::.:|..|        ||           
  Fly  1295 FDNI-IQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVL 1358

Mouse  1162 ----------------------------------------------------------------- 1161
                                                                             
  Fly  1359 PLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVA 1423

Mouse  1162 ------------------------------------------------PAEEQPV---------- 1168
                                                            |.||:|:          
  Fly  1424 MEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKM 1488

Mouse  1169 -----------------------------------------------------IE---------- 1170
                                                                 ||          
  Fly  1489 PRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSL 1553

Mouse  1171 --------------------------------------------------PEETLE--------- 1176
                                                              |:.||:         
  Fly  1554 KTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSAR 1618

Mouse  1177 ----------------------------------------------------------------- 1176
                                                                             
  Fly  1619 TESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRN 1683

Mouse  1177 ----------------------PEACFTEGCVQR--FKC-----CQISVEEGRGKQWWNLRRTCF 1212
                                  |:.||.:.|...  |:|     |   ::....|.|..:|....
  Fly  1684 SQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSC---MDTQSAKHWTRVRTAVL 1745

Mouse  1213 RIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQ 1277
            .:|:...||.|::.:|..||..|.||||.:|:.||:|.:|.:.:..|..||::||:|||:|.|:.
  Fly  1746 TVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFS 1810

Mouse  1278 TYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLG 1342
            .|||:.|..|||:||.||:.||....  ...|..::|||||||||||||:||::|||:|||||:.
  Fly  1811 KYFTSFWTILDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMY 1873

Mouse  1343 AIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNTTTGDIFEISEVNNHSDCLKLIERNETAR 1407
            |||||.|||||||:||||||||||..|.|||:.||| ..|::..|:|||:..||   ||:|.|  
  Fly  1874 AIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN-EMGELLPITEVNDKWDC---IEQNYT-- 1932

Mouse  1408 WKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSF 1472
            |.|.|:.||:||.|||:|||||||:|||::|..|||:|.|:|||:.|.:||.|:||||||:.|||
  Fly  1933 WINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSF 1997

Mouse  1473 FTLNLFIGVIIDNFNQQKKKFGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVF 1535
            |||||||||||||||..|||:.|  .::|:||.||.||.||||||.|||||.|.||.|.|..|.:
  Fly  1998 FTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFY 2062

Mouse  1536 DFVTRQVFDISIMILICLNMVTMMVETDDQSDYVTSILSRINLVFIVLFTGECVLKLISLRHYYF 1600
            |....:.|:|:|.:||.|||:||.:|..||...|..||...|..|..:|..|.::|::.||::||
  Fly  2063 DLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYF 2127

Mouse  1601 TIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMM 1665
            |:.||:|||::|:.||.|:.:.:::....:||||.||:|:.||||||||||.|||||.|||||::
  Fly  2128 TVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVV 2192

Mouse  1666 SLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLL 1730
            |||||||||.||.|:.|||||.|||.|..||.:..:|||.||:|||.||..||::.|||||:.:|
  Fly  2193 SLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVL 2257

Mouse  1731 APILNSKPPDCDP---NKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1792
            ..:: .:||||||   ...|      |:||:|.:.|.:|.|:||||:::|:|||||:|||||:.|
  Fly  2258 ESLM-IQPPDCDPFIHGHTN------GNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQA 2315

Mouse  1793 TEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMV 1857
            .:|....:.|||.||||..|.|:||.||||:.|.:||.|.|:|:|||.:.:||.:.|::.:||:.
  Fly  2316 HQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPIS 2380

Mouse  1858 SGDRIHCLDILFAFTKRVLGESGEMD---ALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSA 1919
            .|::|||||||.|..|.|||...|.|   .|:.||:.:|....|::...:.:::|...|::|.:|
  Fly  2381 KGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAA 2445

Mouse  1920 VIIQRAYRRHLLKRTVKQAS 1939
            ..||..::.:|.::..|:.|
  Fly  2446 KTIQTGWKEYLRRKREKERS 2465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Scn1aNP_001300926.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..60 3/10 (30%)
I. /evidence=ECO:0000250|UniProtKB:P04774 110..454 151/343 (44%)
Ion_trans 127..433 CDD:366146 143/305 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 455..528 17/84 (20%)
Na_trans_cytopl 510..718 CDD:371806 34/219 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 584..627 3/42 (7%)
II. /evidence=ECO:0000250|UniProtKB:P04774 750..1022 141/277 (51%)
Ion_trans 767..980 CDD:366146 117/215 (54%)
Na_trans_assoc 1006..1213 CDD:368948 69/824 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1129..1163 11/173 (6%)
III. /evidence=ECO:0000250|UniProtKB:P04774 1200..1514 178/315 (57%)
Ion_trans 1217..1492 CDD:366146 161/274 (59%)
Na_channel_gate 1484..1536 CDD:240441 32/53 (60%)
IV. /evidence=ECO:0000250|UniProtKB:P04774 1523..1821 153/300 (51%)
Ion_trans 1540..1796 CDD:366146 133/258 (52%)
S1-S2 loop of repeat IV. /evidence=ECO:0000269|PubMed:27281198 1561..1571 4/9 (44%)
S3b-S4 loop of repeat IV. /evidence=ECO:0000269|PubMed:27281198 1619..1636 4/16 (25%)
GPHH 1808..1855 CDD:374878 22/46 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1984..2009
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 114/240 (48%)
Ion_trans 705..902 CDD:278921 106/200 (53%)
Ion_trans 1768..2019 CDD:278921 157/258 (61%)
Na_channel_gate 2009..2063 CDD:240441 32/53 (60%)
Ion_trans 2085..2320 CDD:278921 125/241 (52%)
GPHH 2331..2386 CDD:293510 25/54 (46%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.720

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