DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Scn10a and NaCP60E

DIOPT Version :9

Sequence 1:NP_001192250.1 Gene:Scn10a / 20264 MGIID:108029 Length:1958 Species:Mus musculus
Sequence 2:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster


Alignment Length:2646 Identity:824/2646 - (31%)
Similarity:1182/2646 - (44%) Gaps:850/2646 - (32%)


- Green bases have known domain annotations that are detailed below.


Mouse    25 EKQIAAHRA---AKKGRPKQRGQ-----KDKSEKPRPQLDLKACNQLPRFYGELPAELVGEPLED 81
            ||.:|.|:.   .::.:.|...:     ::....||.:..::..:.|||.:...|..:.|:|||:
  Fly    11 EKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLEE 75

Mouse    82 LDPFYSTHRTFIVLDK---SRTISRFSATWALWLFSPFNLIRRTAIKVSVHSWFSIFITVTILVN 143
            :|.|. ...||.|:.|   ...|.||:.|.:|:||.|::..||..:.::.:.:|...:..|||.|
  Fly    76 IDTFI-YEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFN 139

Mouse   144 CVCMTRTDLPEKLEYAFTVVYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGAAIDL 208
            |:.:..|:..|:.||.|..:|:.|.:|||:|:||.||::||||:|||||||.|||..|....:::
  Fly   140 CIFLAMTETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEV 204

Mouse   209 RGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFALVGLQLFKGNLK 273
            ..::|||||||||||||||::||||.|:.||:||.|:||:|..||:|||.||||..||::.|.|:
  Fly   205 GNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELR 269

Mouse   274 NKCIKNGTDPHKADNLSSEMAGDIFIKPGTTD---------PLLCGNGSDAGHCPNDYVCRKTSD 329
            |||::.  .|....|:|..   |..|....||         |:||||.:.|.|||.:|||....:
  Fly   270 NKCVRQ--VPTDWTNVSHT---DWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCVGE 329

Mouse   330 NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMVFFVLVIFLGSFYLVNLILAV 394
            ||:..||:||:|.|:.|:.|:|:|.|.||.:|...|...|.|.:.||.:|:|.|||||:||:|||
  Fly   330 NPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAV 394

Mouse   395 VTMAYEEQSQATIAEIEAKEKKFKEALE-----VLQKEQEVLAALGIDTTS---LYSHNGSPLAP 451
            |.::|||:     |||..:|:| |:.|:     ....:..||....::..:   :.|..|..||.
  Fly   395 VALSYEEE-----AEITNEERK-KDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLAS 453

Mouse   452 KNANERRPRVKSRMSEGST---------DDNRSLQSDP------------------------YNQ 483
            .:..:.|.:......||.|         |||:|..:.|                        |.|
  Fly   454 YSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQ 518

Mouse   484 R------------------------RMSF----LGL-----------------SSGRRRASHSSV 503
            .                        |:||    :|:                 :||:..::.|.|
  Fly   519 MEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGV 583

Mouse   504 FHFRAPSQDVSFPDGILDDGVFHGDQESRRSSILLGRGAGQAGPLPRSPLPQSPNPGPRRGEEGQ 568
              .|..|||.|   |::||   |.:|::...   :|.                            
  Fly   584 --NRESSQDDS---GVVDD---HEEQDTTND---MGH---------------------------- 609

Mouse   569 RGVPTGELATGAPEGPALDAAGQ----KNFLSADYLNEPFRAQRAMSVVSIMTSVIEELEESKLK 629
              |.|.|||....|...:...|.    ||. :...|::.|.::    ||     ||::|.:.  .
  Fly   610 --VSTVELALSPREVRLIKCNGNIARIKNH-NVYALHQEFSSE----VV-----VIDDLPDR--N 660

Mouse   630 CPPCLISLAQKYLIWECC--PKWKKFKMVLFELVTDPFAELTITLCIVVNTVFMAMEHYPMTDAF 692
            |..|        :.| |.  ..|.:|:..|:::|.||..||.||||||:||.|:||||:.|:::|
  Fly   661 CDRC--------VHW-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESF 716

Mouse   693 DAMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSLLELSTSKKGSLSVLRTF 757
            ...|..||.|||..||.|...|::|... .:|...|||||.:|||.|||::.......|||||..
  Fly   717 RNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGL 780

Mouse   758 RLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTFILAIIVFIFALVGKQLLSENYGCRR---DGI 819
            |||||.|||:||.|:.:|:.||.:::|||||||.||.|:::|||::|.||.|::|...:   |.:
  Fly   781 RLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPV 845

Mouse   820 SVWNGERLRWHMCDFFHSFLVVFRILCGEWIENMWVCMEVSQDY---ICLTLFLTVMVLGNLVVL 881
            .       ||:..||||||:::||||||||||.:|.||...::.   .|..:||..:|:||.:||
  Fly   846 P-------RWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVL 903

Mouse   882 NLFIALLLNSFSADNLTAPEDD-GEVNNLQVALARI----------------------------- 916
            |||:|||||||:::.|.:.::: ||.:.|..::.|:                             
  Fly   904 NLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLD 968

Mouse   917 ------QVFGHRAS--------------------------------------------------- 924
                  |...|:|:                                                   
  Fly   969 AQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDG 1033

Mouse   925 ----------------------------------------------------RAITSYIRSHCRL 937
                                                                :.:|.::::..||
  Fly  1034 LEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRL 1098

Mouse   938 R---------------------------------------------------------------- 938
            :                                                                
  Fly  1099 QHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYG 1163

Mouse   939 -------WPKVETQLGMKPP--------------------LTSCKAE--NH----------IATD 964
                   :.|.:..|..:.|                    |.|.:||  .|          |..|
  Fly  1164 SEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQD 1228

Mouse   965 AVNAAVGNLAKPALG--------------------------------------GPKEN-----HG 986
            .:.:..|||.:..|.                                      |..||     |.
  Fly  1229 ELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHS 1293

Mouse   987 DF---------------------------ITDPN---------VWVSVPIAEGESDLDELEE--- 1012
            :|                           :::|:         :...:.|..|.|:....:|   
  Fly  1294 EFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVL 1358

Mouse  1013 -----------DVEHASQS---SWQEESPKGQQELLQQVQKCEDH-------------------- 1043
                       .|...|||   :.|.:|.|.::..|::.:|.::.                    
  Fly  1359 PLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVA 1423

Mouse  1044 ---QAARSPPSGMSSEDLAPYLG----------ERWQR------------------------EES 1071
               .|..:..:..:..:.:|:|.          :|::|                        |:.
  Fly  1424 MEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKM 1488

Mouse  1072 PR---------------------------------------VPA--------------------- 1076
            ||                                       |||                     
  Fly  1489 PRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSL 1553

Mouse  1077 ----------------------------------------------------------------- 1076
                                                                             
  Fly  1554 KTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSAR 1618

Mouse  1077 -----EGVDDTSS---------SEGSTVDCPDPEEILRKIPELAEE--------LDE-------- 1111
                 .|..|.||         :|.|....||..:.......|.|:        :|:        
  Fly  1619 TESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRN 1683

Mouse  1112 ----------------------PDDCFPEGCTR----RCP----CCKVNTSKFPWATGWQVRKTC 1146
                                  ||||||:.|..    |||    |....::|. |.   :||...
  Fly  1684 SQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKH-WT---RVRTAV 1744

Mouse  1147 YRIVEHSWFESFIIFMILLSSGALAFEDNYLEEKPRVKSVLEYTDRVFTFIFVFEMLLKWVAYGF 1211
            ..:|:...||.|::.:|..||..|.|||..|::...:|.||.:.:..|..|||.||:|||:|.||
  Fly  1745 LTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF 1809

Mouse  1212 KKYFTNAWCWLDFLIVNISLTSLIAKILEYSDVASIKALRTLRALRPLRALSRFEGMRVVVDALV 1276
            .||||:.|..|||:||.:|:.||:  |.|..::..:::||||||||||||:||::|||:||:||:
  Fly  1810 SKYFTSFWTILDFIIVFVSVFSLL--IEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALM 1872

Mouse  1277 GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFSRCVDTRSNPFSVVNSTFVTNKSDCYNQNNTGH 1341
            .|||||.|||||||:||||||||||..|.|||.:||:.......:   |.|.:|.||..||.|  
  Fly  1873 YAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPI---TEVNDKWDCIEQNYT-- 1932

Mouse  1342 FFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSRDINSQPNWEESLYMYLYFVVFIIFG 1406
              |:|.|:.||:|.||||||||||||:|||::|..|||:|.::.||..|.:||.|:|||:||:.|
  Fly  1933 --WINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCG 1995

Mouse  1407 GFFTLNLFVGVIIDNFNQQKKKIRG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGF 1469
            .|||||||:||||||||..|||..|  .::|:||.||.||.||||||.|||||.|.||:|.:...
  Fly  1996 SFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAM 2060

Mouse  1470 VFDIVTRQAFDIIIMALICLNMITMMVETDNQSEEKTKVLGRINQFFVAVFTGECVMKMFALRQY 1534
            .:|:...:.|:|.|..||.|||:||.:|..:|......:|...|.||..||..|.::|:..||.:
  Fly  2061 FYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYH 2125

Mouse  1535 YFTNGWNVFDFIVVILSISSLLFSAILSSLESYFSPTLLRVIRLARIGRILRLIRAAKGIRTLLF 1599
            |||..||||||::|:.||..:|...|:..|.  .|||||||:|:.|||||||||:||||||.|||
  Fly  2126 YFTVPWNVFDFLLVLASIFGILMEDIMIDLP--ISPTLLRVVRVFRIGRILRLIKAAKGIRKLLF 2188

Mouse  1600 ALMMSLPALFNIGLLLFLVMFIYSIFGMASFANVIDEAGIDDMFNFKTFGNSMLCLFQITTSAGW 1664
            ||::|||||||||.||.|:.|||:|.||:.|.||..:..:|||.||:|||.||..||::.|||||
  Fly  2189 ALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGW 2253

Mouse  1665 DGLLSPILNTGPPYCDPNRPNSNG-SKGNCGSPAVGILFFTTYIIISFLIVVNMYIAVILENFNV 1728
            :.:|..:: ..||.||   |..:| :.||||.|.:.|.:||::||||::||:|||||:||||||.
  Fly  2254 NDVLESLM-IQPPDCD---PFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQ 2314

Mouse  1729 ATEESTEPLSEDDFDMFYETWEKFDPEATQFIAFSALSDFADTLSGPLRIPKPNQNILIQMDLPL 1793
            |.:|....:.|||.:|||..|.|:||.|||||.||.||||..:|..||.|.|||...|:..:||:
  Fly  2315 AHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPI 2379

Mouse  1794 VPGDKIHCLDILFAFTKNVLGESGELDS---LKTNMEEKFMATNLSKASYEPIATTLRCKQEDIS 1855
            ..|:||||||||.|..|:|||...|.|:   |:..|:.||.....::...|.:::|...|:::.:
  Fly  2380 SKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKA 2444

Mouse  1856 ATIIQKAYRNYMLQRSLMLSNPLHVPRAEEDGVSLPREGYVTFMANDNGGLPDKSETASATSFPP 1920
            |..||..::.|:.::           |.:|               ..|.|     ::|:.||.|.
  Fly  2445 AKTIQTGWKEYLRRK-----------REKE---------------RSNSG-----DSATQTSSPG 2478

Mouse  1921 SYDSVTRGL--------------SDRANISTSSSMQNEDEVTAKEG 1952
            .:.|....|              |.||:...||...:..:::...|
  Fly  2479 GWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAG 2524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Scn10aNP_001192250.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 27..54 5/34 (15%)
I. /evidence=ECO:0000305 116..404 138/296 (47%)
Ion_trans 147..406 CDD:278921 130/267 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..483 13/71 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 539..583 6/43 (14%)
II. /evidence=ECO:0000305 646..910 127/272 (47%)
Ion_trans 681..893 CDD:278921 105/217 (48%)
Na_trans_assoc 903..1148 CDD:284034 80/824 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1006..1094 27/300 (9%)
III. /evidence=ECO:0000305 1141..1450 168/310 (54%)
Ion_trans 1170..1428 CDD:278921 146/257 (57%)
Na_channel_gate 1420..1472 CDD:240441 30/53 (57%)
IV. /evidence=ECO:0000305 1459..1758 153/299 (51%)
Ion_trans 1494..1733 CDD:278921 127/239 (53%)
GPHH 1743..1800 CDD:293510 30/56 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1901..1958 14/66 (21%)
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 109/223 (49%)
Ion_trans 705..902 CDD:278921 94/204 (46%)
Ion_trans 1768..2019 CDD:278921 148/259 (57%)
Na_channel_gate 2009..2063 CDD:240441 30/53 (57%)
Ion_trans 2085..2320 CDD:278921 128/240 (53%)
GPHH 2331..2386 CDD:293510 29/54 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 1 1.100 - - LDO PTHR10037
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.820

Return to query results.
Submit another query.