DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment STK32A and Akt1

DIOPT Version :9

Sequence 1:	NP_001274669.1	Gene:	STK32A / 202374	HGNCID:	28317	Length:	407	Species:	Homo sapiens
Sequence 2:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster

Alignment Length:	293	Identity:	98/293 - (33%)
Similarity:	162/293 - (55%)	Gaps:	21/293 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    18 VNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPF 82
            |..::||.|:.:|||:||||.:.::..|.|:||:|.:.|:..::::||.:...|.::::...|||
  Fly   261 VTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPF 325

Human    83 LVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQRIIHRDM 147
            |::|.||||..:.:..|:..:.||:|.:||.....|.|:..:.:..|::.||.||.:|.||:||:
  Fly   326 LISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDL 390

Human   148 KPDNILLDEHGHVHITDFNIAAMLPRETQIT------TMAGTKPYMAPEMFSSRKGAGYSFAVDW 206
            |.:|:|||:.||:.:.||.:.     :..||      |..||..|:|||:....   .|..||||
  Fly   391 KLENLLLDKDGHIKVADFGLC-----KEDITYGRTTKTFCGTPEYLAPEVLDDN---DYGQAVDW 447

Human   207 WSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVSLLKKLLEPNPDQRF-- 269
            |..||..||::.||.|::.|.......::...|   |.:|...:.|..:||..||..:|.:|.
  Fly   448 WGTGVVMYEMICGRLPFYNRDHDVLFTLILVEE---VKFPRNITDEAKNLLAGLLAKDPKKRLGG 509

Human   270 --SQLSDVQNFPYMNDINWDAVFQKRLIPGFIP 300
              ..:.::|..|:...|||..:..|::.|.|.|
  Fly   510 GKDDVKEIQAHPFFASINWTDLVLKKIPPPFKP 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STK32A	NP_001274669.1	STKc_Yank1	22..281	CDD:270730	90/268 (34%)
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	90/267 (34%)
		STKc_PKB	270..590	CDD:270723	94/284 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910