DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ENO1 and Eno

DIOPT Version :9

Sequence 1:	NP_001340275.1	Gene:	ENO1 / 2023	HGNCID:	3350	Length:	434	Species:	Homo sapiens
Sequence 2:	NP_722721.1	Gene:	Eno / 33351	FlyBaseID:	FBgn0000579	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	432	Identity:	311/432 - (71%)
Similarity:	360/432 - (83%)	Gaps:	1/432 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSRP 65
            |:|..|.||:|:||||||||||||.|..||||||||||||||::||||||||||..|.||.|.:.
  Fly    68 MTIKAIKARQIYDSRGNPTVEVDLTTELGLFRAAVPSGASTGVHEALELRDNDKANYHGKSVLKA 132

Human    66 IKYINEFLAPALCTQKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPL 130
            :.::|:.|.|.|....|:|.:|..||..||::|||||||||||||||||||||.||||.:|||||
  Fly   133 VGHVNDTLGPELIKANLDVVDQASIDNFMIKLDGTENKSKFGANAILGVSLAVAKAGAAKKGVPL 197

Human   131 YRHIADLAGNSEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFREAMRIGAEVYHNLKNV 195
            |:||||||||.|:|||||||||||||||||||||||||||||.||.:|.|||::|:||||:||||
  Fly   198 YKHIADLAGNKEIILPVPAFNVINGGSHAGNKLAMQEFMILPTGATSFTEAMKMGSEVYHHLKNV 262

Human   196 IKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGYTDKVVIGMDVAASEFFRSGKYDLD 260
            ||.|:|.|||.|||||||||||..|||.|.|:..||.|||||.|:.||||||||||::.|:||||
  Fly   263 IKAKFGLDATAVGDEGGFAPNIQSNKEALNLISDAIAKAGYTGKIEIGMDVAASEFYKDGQYDLD 327

Human   261 FKS-PDDPSRYISPDQLADLYKSFIKDYPVVSIEDPFDQDDWGAWQKFTASAGIQVVGDDLTVTN 324
            ||: ..|.|:::..|:||:||:.||||:|:||||||||||.|.||...|....||:|||||||||
  Fly   328 FKNEKSDKSQWLPADKLANLYQEFIKDFPIVSIEDPFDQDHWEAWSNLTGCTDIQIVGDDLTVTN 392

Human   325 PKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLAQANGWGVMVSHRSGETEDTFIADLVVGLC 389
            |||||.||.:|:||||||||||||:||||:.|..||:.||||.|||||||||||:||.||||||.
  Fly   393 PKRIATAVEKKACNCLLLKVNQIGTVTESIAAHLLAKKNGWGTMVSHRSGETEDSFIGDLVVGLS 457

Human   390 TGQIKTGAPCRSERLAKYNQLLRIEEELGSKAKFAGRNFRNP 431
            ||||||||||||||||||||:||||||:|:..||||::||.|
  Fly   458 TGQIKTGAPCRSERLAKYNQILRIEEEIGAGVKFAGKSFRKP 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ENO1	NP_001340275.1	PLN00191	2..432	CDD:215095	310/431 (72%)
Eno	NP_722721.1	PLN00191	69..499	CDD:215095	309/429 (72%)
Eno	NP_722721.1	enolase	72..484	CDD:239429	299/411 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154048
Domainoid	1	1.000	436	1.000	Domainoid score	I570
eggNOG	1	0.900	-	-		E1_COG0148
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134343
Inparanoid	1	1.050	639	1.000	Inparanoid score	I820
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60632
OrthoDB	1	1.010	-	-		D325232at33208
OrthoFinder	1	1.000	-	-		FOG0000613
OrthoInspector	1	1.000	-	-		otm41691
orthoMCL	1	0.900	-	-		OOG6_100260
Panther	1	1.100	-	-	O	PTHR11902
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R397
SonicParanoid	1	1.000	-	-		X347
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800