DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sag and Arr1

DIOPT Version :9

Sequence 1:	NP_033144.1	Gene:	Sag / 20215	MGIID:	98227	Length:	403	Species:	Mus musculus
Sequence 2:	NP_001246073.1	Gene:	Arr1 / 35078	FlyBaseID:	FBgn0000120	Length:	364	Species:	Drosophila melanogaster

Alignment Length:	357	Identity:	158/357 - (44%)
Similarity:	225/357 - (63%)	Gaps:	11/357 - (3%)

- Green bases have known domain annotations that are detailed below.

Mouse    13 IFKKVSRDKSVTIYLGKRDYVDHVSQVEPVDGVVLVDPELVK-GKKVYVTLTCAFRYGQEDIDVM 76
            :|||.|.:..:|:|:.:||:||.|:||||:||::::|.|.|: .:|::|.|.|.||||:||.:::
  Fly     7 VFKKCSPNNMITLYMNRRDFVDSVTQVEPIDGIIVLDDEYVRQNRKIFVQLVCNFRYGREDDEMI 71

Mouse    77 GLTFRRDLYFSRVQVYPPVGAMSVLTQLQESLLKKLGDNTYPFLLTFPDYLPCSVMLQPAPQDVG 141
            ||.|:::|.....||.||......||::||.||||||.|.|||::..|...|.||:||....|..
  Fly    72 GLRFQKELTLVSQQVCPPQKQDIQLTKMQERLLKKLGSNAYPFVMQMPPSSPASVVLQQKASDES 136

Mouse   142 KSCGVDFEVKAFASDITDPEEDKIPKKSSVRLLIRKVQHAPPEMGPQPSAEASWQFFMSDKPLNL 206
            :.|||.:.||.|..   |.:.|:..::|::.|.|||||:||.:.|.||.......|.:|...|.|
  Fly   137 QPCGVQYFVKIFTG---DSDCDRSHRRSTINLGIRKVQYAPTKQGIQPCTVVRKDFLLSPGELEL 198

Mouse   207 SVSLSKEIYFHGEPIPVTVTVTNNTDKVVKKIKVSVEQIANVVLYSSDYYVKPVASEETQE--KV 269
            .|:|.|::|.|||.|.|.:.|.||::|||||||..|:|..:|||:.:..:...:|..||.|  .:
  Fly   199 EVTLDKQLYHHGEKISVNICVRNNSNKVVKKIKAMVQQGVDVVLFQNGQFRNTIAFMETSEGCPL 263

Mouse   270 QPNSTLTKTLVLVPLLANNRERRGIALDGKIKHEDTNLASSTIIKEGIDRTVMGILVSYHIKVKL 334
            .|.|:|.|.:.|||.|..|.:|.|||::|.||.:||.|||:|:|.....|...||:|||.:||||
  Fly   264 NPGSSLQKVMYLVPTLVANCDRAGIAVEGDIKRKDTALASTTLIASQDARDAFGIIVSYAVKVKL 328

Mouse   335 TVSGFLGELTSSEVATEVPFRLMHPQPEDPAK 366
                |||.| ..|:..|:||.||||:|...|:
  Fly   329 ----FLGAL-GGELCAELPFILMHPKPSRKAQ 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sag	NP_033144.1	Interaction with RHO. /evidence=ECO:0000269\|PubMed:28753425	11..19		3/5 (60%)
		Arrestin_N	23..181	CDD:334019	70/158 (44%)
		Arrestin_C	200..361	CDD:214976	76/162 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..403
Arr1	NP_001246073.1	Arrestin_N	17..173	CDD:304627	70/158 (44%)
Arr1	NP_001246073.1	Arrestin_C	192..350	CDD:214976	76/162 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3865
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52566
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11792
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920