Protein Alignment EN1 and HGTX

DIOPT Version :10

• Sequence 1: NP_001417.3
• Gene: EN1 / 2019
• HGNCID: 3342
• Length: 392
• Species: Homo sapiens
• Sequence 2: NP_001368954.1
• Gene: HGTX / 53446
• FlyBaseID: FBgn0040318
• Length: 587
• Species: Drosophila melanogaster
• Alignment Length: 536
• Identity: 115/536 - (21%)
• Similarity: 161/536 - (30%)
• Gaps: 215/536 - (40%)

Human    25 GGLSLSLSPGASGSSGSGSDGDSVPVSPQPAPPSPPAAPCLPPLAHHPHLPPH-------PP--- 79
            |...||::| |.|||           :|.|.||.|.|......||....|..:       ||
  Fly     3 GSPFLSITP-AGGSS-----------NPSPTPPPPDAKVAAKQLAQSFQLSANSAFNLALPPAFY 55

Human    80 -PPPPQH-------------------------LAAPAHQPQPAAQLHR----TTNFFIDNILRPD 114
             .||.||                         .||....|..|||.|.    .:|.|.|......
  Fly    56 RAPPQQHPECLDYGHEAPEMDLINPYMRHHSFAAAAQGSPPSAAQRHHLAAAMSNGFADVHAHAM 120

Human   115 FGCKKEQPPPQLLVAAAARG--------------------------GAGGGGRVERDRGQT---- 149
            .....:|.......||||..                          .|.|||..:.|...|
  Fly   121 AAADYQQQLADYHSAAAAAAVYANNNNNNNNNSSNNNNSSPLMLLKAAHGGGLKDSDSPSTTPPP 185

Human   150 -------------------AAGRDPV--HPLGTRAPGAASLLCAPDANCGPPDG----------S 183
                               :.|.|..  :.|..|:.||.......::...||.|          |
  Fly   186 ASSRLHSDSSPSPRYEHNSSPGVDSAKSYALSQRSSGAEDPCQTSESASPPPQGQNDYSPENLSS 250

Human   184 QPA----------AAGAGASKAGNP------------------------------------AAAA 202
            |.|          .|...|:.||||                                    ...:
  Fly   251 QRAKFQHHHGVNPLALHNANHAGNPGCHNNNNHMDHKLPLSFLGPPLAALHSMTTEMKGQGVGGS 315

Human   203 AAAAAAVAAAAAAAAAKPSDTGGGGSGGGAG----SPGAQGTKYPEHGNPAIL------------ 251
            :|:|..::.:.:..:...||.|.|||...:.    :..:||...| ||...||
  Fly   316 SASANGLSYSHSPNSHLISDRGSGGSSSSSSTTTTNTNSQGAPNP-HGIDTILSKPPPVTSAGLS 379

Human   252 -LMG-------------------SANGGPVVKTDS-----QQPLVWP----------AWVYCTRY 281
             |.|                   |.:.|..:||.:     :..|.||          ||  ..|.
  Fly   380 ALTGAGIPRFSIAAAAAGMAQYLSQSQGAPLKTHAGHIVDRTHLYWPGLQGLVANPIAW--RERL 442

Human   282 SDRPSSGPRTRKLKKKKNEKEDKRPRT--AFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNE 344
            |:..|:...........|:|:.|:..|  .|:.:|:..|:..|:..:|:....|..||..|.::|
  Fly   443 SNTMSANLSQSHQHHPSNDKDGKKKHTRPTFSGQQIFALEKTFEQTKYLAGPERAKLAYALGMSE 507

Human   345 SQIKIWFQNKRAKIKK 360
            ||:|:||||:|.|.:|
  Fly   508 SQVKVWFQNRRTKWRK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EN1	NP_001417.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		29/110 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..164		11/82 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..251		11/35 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..306		5/23 (22%)
		Homeodomain	305..360	CDD:459649	20/56 (36%)
		Engrail_1_C_sig	361..391	CDD:431338	115/536 (21%)
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	36/209 (17%)
		Homeodomain	465..523	CDD:459649	21/57 (37%)