Protein Alignment EN1 and E5

DIOPT Version :10

• Sequence 1: NP_001417.3
• Gene: EN1 / 2019
• HGNCID: 3342
• Length: 392
• Species: Homo sapiens
• Sequence 2: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 378
• Identity: 90/378 - (23%)
• Similarity: 120/378 - (31%)
• Gaps: 161/378 - (42%)

Human    11 QRDSALGAAAAATPGGLSLSLSPGASG--------SSGSGSDGDSVPVSPQPAP--------PSP 59
            ||.....:.:....||     :|.|:|        |||:|:....:...|.|||        .||
  Fly   116 QRSPVSRSPSPPNAGG-----NPAAAGNTAKSGDPSSGTGNPPTLIRPLPLPAPNLALIGNRTSP 175

Human    60 PAAPCLPPLAHHPHLPPHPPPPPPQHLAAPAHQPQPAAQLHRTTNFFIDNILRPDFGCKKEQPPP 124
            .|      :|.....|||||..||..|||........|..|:.               :::|...
  Fly   176 NA------MAVRMAGPPHPPSQPPPFLAAQFQMAAALAHHHQQ---------------QQQQQQQ 219

Human   125 QLLVAAAARGGAGGGGRVERDRGQTAAGRDPVHPLGTRAPGAASLLCAPDANCGPPDGSQPAAAG 189
            ||                                              |....|||.|..|
  Fly   220 QL----------------------------------------------PPVPTGPPHGPHP---- 234

Human   190 AGASKAGNPAAAAAAAAAAVAAAAAAAAAKPSDTGGGGSGGG--AGSPGAQGTKYPEHGNPAILL 252
                                       ...|.....|...||  .|.|       |.||:..
  Fly   235 ---------------------------HLPPGQIPLGIFPGGPHPGHP-------PPHGHHP--- 262

Human   253 MGSANGGPVVKTDSQQPLVWPAWV----------YCTRYSDRPSSGPRTRKLKKKKNEKEDKRPR 307
            .|||   |.:..|| .|| :| |:          :...:..:|...|              ||.|
  Fly   263 FGSA---PHLIRDS-YPL-YP-WLLSRHGRIFPRFPGNFLFQPFRKP--------------KRVR 307

Human   308 TAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIWFQNKRAKIKK 360
            |||:..||.:|:..|:.|.|:....|:.|||.|||.|:|:|:||||:|.|.|:
  Fly   308 TAFSPTQLLKLEHAFEGNHYVVGAERKQLAQGLSLTETQVKVWFQNRRTKHKR 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EN1	NP_001417.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		30/104 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..164		0/31 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..251		9/33 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..306		3/23 (13%)
		Homeodomain	305..360	CDD:459649	27/54 (50%)
		Engrail_1_C_sig	361..391	CDD:431338	90/378 (24%)
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	28/55 (51%)