Protein Alignment EN1 and NK7.1

DIOPT Version :10

• Sequence 1: NP_001417.3
• Gene: EN1 / 2019
• HGNCID: 3342
• Length: 392
• Species: Homo sapiens
• Sequence 2: NP_650357.2
• Gene: NK7.1 / 41747
• FlyBaseID: FBgn0024321
• Length: 721
• Species: Drosophila melanogaster
• Alignment Length: 443
• Identity: 105/443 - (23%)
• Similarity: 145/443 - (32%)
• Gaps: 169/443 - (38%)

Human     2 EEQQPEPKS-----QRDSALGAAAAATPGGLSLSLSPGASGSSGSGSDGDSVPVSPQPAPPSPPA 61
            :.|||:.::     ||.|....|...|||
  Fly   145 QHQQPQQQTVQLQQQRRSVSTPAITTTPG------------------------------------ 173

Human    62 APCLPPLAHHPH----LPPHPPPPPPQHLAAPAHQPQPAAQLHRTTNFFIDNILRPDFGCKKEQP 122
                ||...|.|    |||||.|          |.              |.:||...| .|||:|
  Fly   174 ----PPTNWHAHVYDRLPPHPTP----------HS--------------IADILGMSF-VKKERP 209

Human   123 PPQLLVAAAARGGAGGGGRVERDRGQTAAGRDPVHPLGTRAPGAASLLCAPDANCGPPDGSQPAA 187
            .    ||..|:|.|.....:             :.|...:.|..:|.:...||:      .:.:|
  Fly   210 E----VAFDAQGPAKSPNSI-------------LKPYQEQQPIRSSSISMSDAS------EEESA 251

Human   188 AGAGASKAGNPAAAAAAAAAAVAAAAAA----------AAAKPSDTGGGGSGGGAGSP------- 235
            |.|||:.|   |.||||.||.:.||..|          ...|..|:.        .||
  Fly   252 AVAGATSA---ATAAAAVAATITAATVATPLDQPLNLCVVKKSRDSN--------NSPMPATKQS 305

Human   236 ---GAQGTKYPEHGNPAI---------------------------LLMGSANGGPVVKTDSQQPL 270
               |...||....|.||.                           .||.:.:..|....::|...
  Fly   306 QILGKSATKKESSGKPAAKKKKLSSTVALPPDISPTGSSDSLMRDKLMANNSSSPGSNVNAQMQS 370

Human   271 VWPAWVYCTRYSDRPSSGPRTRKLKKKKNEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQT 335
            ...:.:..|  .|...||....:.|||        .||.||..|:..|:..|:..:|::...|..
  Fly   371 NANSTLETT--EDDSDSGSTDARRKKK--------ARTTFTGRQIFELEKMFENKKYLSASERTE 425

Human   336 LAQELSLNESQIKIWFQNKRAKIKKATGIKNGLALHLMAQ----GLYNHSTTT 384
            :|:.|.:.|:|:||||||:|.|.||...:.|..|....:.    |....:|||
  Fly   426 MAKLLMVTETQVKIWFQNRRTKWKKQDNVTNNEAAEHKSSNAKPGATGTATTT 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EN1	NP_001417.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		21/106 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..164		4/31 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..251		10/68 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..306		6/23 (26%)
		Homeodomain	305..360	CDD:459649	21/54 (39%)
		Engrail_1_C_sig	361..391	CDD:431338	6/28 (21%)
NK7.1	NP_650357.2	Homeodomain	394..450	CDD:459649	23/63 (37%)