Protein Alignment EN1 and lab

DIOPT Version :10

• Sequence 1: NP_001417.3
• Gene: EN1 / 2019
• HGNCID: 3342
• Length: 392
• Species: Homo sapiens
• Sequence 2: NP_476613.1
• Gene: lab / 40817
• FlyBaseID: FBgn0002522
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 417
• Identity: 103/417 - (24%)
• Similarity: 140/417 - (33%)
• Gaps: 180/417 - (43%)

Human     2 EEQQPEPKSQRDSALGAAA-------AATP-GGLSLS-----LSPGASGSSGSGSDGDSVPVSPQ 53
            ::|||..:.|.......||       :.:| ||::..     :|||:|.||.:.:...:.|.|.|
  Fly   315 QQQQPHQQPQHPQNQSPAAHQQHHQNSVSPNGGMNRQQRGGVISPGSSTSSSTSASNGAHPASTQ 379

Human    54 PAPPSPPAAPCLPPLAHHPHLPPH---------PPPPPPQHLA---APAHQPQPAAQLHRTTNFF 106
            ...|:           |...:|.:         |.|..|:..|   |..|..|...||.
  Fly   380 SKSPN-----------HSSSIPTYKWMQLKRNVPKPQAPKLPASGIASMHDYQMNGQLD------ 427

Human   107 IDNILRPDFGCKKEQPPPQLLVAAAARGGAGGGGRVERDRGQTAAGRDPVHPLGTRAPGAASLLC 171
                                    ..|||.|||..|         |..||...|..:||...:|.
  Fly   428 ------------------------MCRGGGGGGSGV---------GNGPVGVGGNGSPGIGGVLS 459

Human   172 APD----ANCGPPDGSQPAAAGAGASKAGNPAAAAAAAAAAVAAAAAAAAAKPSDTGGG-GSGGG 231
            ..:    ||                                  :||||.:|.|:..|.| |||.|
  Fly   460 VQNSLIMAN----------------------------------SAAAAGSAHPNGMGVGLGSGSG 490

Human   232 AGSPGAQGTKYPEHGNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSGPRTRKLKK 296
            ..|                                           |:..|:..:||
  Fly   491 LSS-------------------------------------------CSLSSNTNNSG-------- 504

Human   297 KKNEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIWFQNKRAKIKKA 361
                      ||.||.:||..|:.||..|||:|..||..:|..|.|||:|:||||||:|.|.||.
  Fly   505 ----------RTNFTNKQLTELEKEFHFNRYLTRARRIEIANTLQLNETQVKIWFQNRRMKQKKR 559

Human   362 TGIKNGLALHLMAQGLYNHSTTTVQDK 388
              :|.||   :.|..|..|||:.:.:|
  Fly   560 --VKEGL---IPADILTQHSTSVISEK 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EN1	NP_001417.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		29/122 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..164		11/31 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..251		8/32 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..306		3/23 (13%)
		Homeodomain	305..360	CDD:459649	29/54 (54%)
		Engrail_1_C_sig	361..391	CDD:431338	9/28 (32%)
lab	NP_476613.1	Homeodomain	505..558	CDD:459649	29/52 (56%)