Protein Alignment EN1 and scro

DIOPT Version :10

• Sequence 1: NP_001417.3
• Gene: EN1 / 2019
• HGNCID: 3342
• Length: 392
• Species: Homo sapiens
• Sequence 2: NP_001015473.1
• Gene: scro / 3355151
• FlyBaseID: FBgn0287186
• Length: 468
• Species: Drosophila melanogaster
• Alignment Length: 385
• Identity: 78/385 - (20%)
• Similarity: 126/385 - (32%)
• Gaps: 118/385 - (30%)

Human     7 EPKSQRDSALGA----AAAATPGGLSLSLSPGASGSSGSGSDGDSVPVSP-----QPAPPSPPAA 62
            |.||.|:..:..    ..|.....|.:||||..:....:.|....|..|.     :.:..:..:.
  Fly    13 ERKSYRELQINRDQYFVTAPNEEDLVMSLSPKDTLIHTAISQHHQVDTSTKLNTNETSTQNTVST 77

Human    63 PCLPPLAHHPHLPPHPPPPPPQHLAAPAHQPQPAAQLHR--------TTNFFIDNILRP-DFGCK 118
            .....:|||            .|..:..|..|.....|:        :|.|.:.:||.| :...:
  Fly    78 AAAAAVAHH------------HHNLSSIHHLQNLHSQHQSTLFNSNHSTPFSVTDILSPIEESYR 130

Human   119 KEQ---PPPQLLVAAAARGGAGGGGRVERDRGQTAAGRDPVHPLGT--RAPGAASLLCAPDANCG 178
            |.:   .||....:.::.......|.:     .|:...:| :.:||  .:||..:.       ||
  Fly   131 KLELNGNPPSPFRSNSSSSSINSPGTL-----TTSTMANP-YAMGTLYHSPGVQTY-------CG 182

Human   179 PPDGSQPA--------AAGAGASKAGNPAAAAAAAAAAVAAAAAAAAAKPSDTGGGGSGGGAGSP 235
            |.|....|        :|....|.|.:|..|.:...                           |.
  Fly   183 PTDNLSLAGHYTDMRNSASWYGSTANDPRFAISRLM---------------------------SS 220

Human   236 GAQGTKYPEHGNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSGPRTRKLKKKKNE 300
            .|.||.  .|       ||:.:|.........:||.:|.
  Fly   221 SASGTM--SH-------MGNMSGLAACSVSDSKPLQFPL-------------------------- 250

Human   301 KEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIWFQNKRAKIKK 360
            .:.::.|..||..|:..|:..|:..||::...|:.||..:.|..:|:||||||.|.|.|:
  Fly   251 AQRRKRRVLFTQAQVYELERRFKQQRYLSAPEREHLASLIHLTPTQVKIWFQNHRYKCKR 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EN1	NP_001417.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		19/101 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..164		5/33 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..251		5/31 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..306		0/23 (0%)
		Homeodomain	305..360	CDD:459649	21/54 (39%)
		Engrail_1_C_sig	361..391	CDD:431338	78/385 (20%)
scro	NP_001015473.1	Homeodomain	254..310	CDD:459649	21/55 (38%)