Protein Alignment EN1 and CG11085

DIOPT Version :10

• Sequence 1: NP_001417.3
• Gene: EN1 / 2019
• HGNCID: 3342
• Length: 392
• Species: Homo sapiens
• Sequence 2: NP_572815.3
• Gene: CG11085 / 32213
• FlyBaseID: FBgn0030408
• Length: 295
• Species: Drosophila melanogaster
• Alignment Length: 227
• Identity: 65/227 - (28%)
• Similarity: 92/227 - (40%)
• Gaps: 69/227 - (30%)

Human   161 TRAPGAASLLCAPDANCGPPDGSQPAAAGAGASKAGNPAAAAAAAAAAVAAAAAAAAAKPSDTGG 225
            ||.||:           |...|......|.|...:|..||||||..||...||||:.|.......
  Fly    78 TRGPGS-----------GTGSGGGGGGGGGGGVASGLSAAAAAAGVAAGLLAAAASGANGDRDAN 131

Human   226 GGSGGGAGSPGAQGTKYPEHGNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSGPR 290
            ||||.|:|  |.....|.||
  Fly   132 GGSGPGSG--GGTSGGYAEH--------------------------------------------- 149

Human   291 TRKLKKKKNEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIWFQNKR 355
              ||:..|:.::.:|.|||||..||..|:.:|:..:|::...|..:|:.|:|:|:|:|.|:||:|
  Fly   150 --KLQLSKSGRKPRRRRTAFTHAQLAYLERKFRCQKYLSVADRSDVAETLNLSETQVKTWYQNRR 212

Human   356 AKIKKATGIKNGLALHLMAQGLYNHSTTTVQD 387
            .|.|:    :|.|.|..:     .|..|..:|
  Fly   213 TKWKR----QNQLRLEQL-----RHQATMEKD 235

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EN1	NP_001417.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..164		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..251		10/31 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..306		3/23 (13%)
		Homeodomain	305..360	CDD:459649	23/54 (43%)
		Engrail_1_C_sig	361..391	CDD:431338	6/27 (22%)
CG11085	NP_572815.3	Homeodomain	161..217	CDD:459649	23/55 (42%)