DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rxra and usp

DIOPT Version :9

Sequence 1:	NP_035435.1	Gene:	Rxra / 20181	MGIID:	98214	Length:	467	Species:	Mus musculus
Sequence 2:	NP_001259168.1	Gene:	usp / 31165	FlyBaseID:	FBgn0003964	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	486	Identity:	208/486 - (42%)
Similarity:	275/486 - (56%)	Gaps:	88/486 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse    56 ISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFGTGSPQLNSPMNPVSSTEDIKPPLGLNG 120
            ||.|:...|....|.:  .||: |...::.....|   .||...:|..|.....:..:.|....|
  Fly    23 ISQLNDSNNSSFSPKA--ESPV-PFMQAMSMVHVL---PGSNSASSNNNSAGDAQMAQAPNSAGG 81

Mouse   121 VLKV-------PAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRD 178
            ....       |.||    .|.:||:|:|||||:|||||||||||||||||||||||||||.||:
  Fly    82 SAAAAVQQQYPPNHP----LSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRE 142

Mouse   179 NKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGK------------------------- 218
            |::|:||||||||||||||||||..||||||||||||||.
  Fly   143 NRNCIIDKRQRNRCQYCRYQKCLTCGMKREAVQEERQRGARNAAGRLSASGGGSSGPGSVGGSSS 207

Mouse   219 --------------DRNENEVESTSSANEDMPVEKILEAELAVEPKTETYVEANMGLNPSSPNDP 269
                          ..|.::...|:|.:.|..:|:|:|||...|.:........:.:.|.|...|
  Fly   208 QGGGGGGGVSGGMGSGNGSDDFMTNSVSRDFSIERIIEAEQRAETQCGDRALTFLRVGPYSTVQP 272

Mouse   270 -----VTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSI-AVKDG 328
                 |:.:||..:||||.:||:|:.:|||:::|||||||||:|.|.|||||:.:..|| ::.||
  Fly   273 DYKGAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAWCSIVSLDDG 337

Mouse   329 --------------------------ILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQM 367
                                      :.|......|||||..|||.|||||:|:||..||:.:.:
  Fly   338 GAGGGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRNSAIKAGVSAIFDRILSELSVKMKRLNL 402

Mouse   368 DKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRS 432
            |:.||.||:||:|:|||.:|:.:.||:|..||||||.|:.:|:.::|...||||:||||||||||
  Fly   403 DRRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRS 467

Mouse   433 IGLKCLEHLFFFKLIGDTPIDTFLMEMLEAP 463
            |.|||.:|||.|::..|.|::...:|.||||
  Fly   468 ISLKCQDHLFLFRITSDRPLEELFLEQLEAP 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rxra	NP_035435.1	Modulating domain. /evidence=ECO:0000250	1..139		20/89 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..112		13/55 (24%)
		Nuc_recep-AF1	18..131	CDD:288658	18/81 (22%)
		NR_DBD_RXR	138..214	CDD:143514	65/75 (87%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:P19793	165..170		4/4 (100%)
		Hinge	206..229		13/61 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..233		10/60 (17%)
		NR_LBD_RXR_like	234..445	CDD:132741	107/242 (44%)
		Required for nuclear export. /evidence=ECO:0000250\|UniProtKB:P19793	353..373		8/19 (42%)
usp	NP_001259168.1	NR_DBD_RXR	102..178	CDD:143514	65/75 (87%)
usp	NP_001259168.1	NR_LBD_RXR_like	237..480	CDD:132741	107/242 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834512
Domainoid	1	1.000	189	1.000	Domainoid score	I3286
eggNOG	1	0.900	-	-		E33208_3BA8J
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2220
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2163
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45637
OrthoDB	1	1.010	-	-		D389616at33208
OrthoFinder	1	1.000	-	-		FOG0001500
OrthoInspector	1	1.000	-	-		otm44370
orthoMCL	1	0.900	-	-		OOG6_103349
Panther	1	1.100	-	-	LDO	PTHR24083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4818
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800