Protein Alignment DENND6A and CG3309

DIOPT Version :10

• Sequence 1: NP_689891.1
• Gene: DENND6A / 201627
• HGNCID: 26635
• Length: 608
• Species: Homo sapiens
• Sequence 2: NP_572216.1
• Gene: CG3309 / 31450
• FlyBaseID: FBgn0029756
• Length: 634
• Species: Drosophila melanogaster
• Alignment Length: 598
• Identity: 240/598 - (40%)
• Similarity: 354/598 - (59%)
• Gaps: 55/598 - (9%)

Human    55 WDSFSAWLHCVCVVGFDLELGQAVEVIYPQHSKLTDREKTNICYLSFPDSNSGCLGDTQFCFRFR 119
            |.:||.|:||.|||.|||.||||:|.:||.....:|:|.:||||::||||||||:|||:|..|.|
  Fly    40 WVNFSQWMHCFCVVTFDLNLGQALEHVYPPAFMPSDQEVSNICYMAFPDSNSGCMGDTKFHMRLR 104

Human   120 QSSGRRVSLHCLLDQFDKDLPVYLKKDPAYFYGYVYFRQVRDKTLKRGYFQKSLVLISKLPYIHF 184
            .:: ||.|    |..::.:....|::|.::::|:|||||.||..|.|||||||.::|::||:.:.
  Fly   105 CTT-RRDS----LPGYNAECSPALRQDGSHYWGFVYFRQKRDANLPRGYFQKSFIIITRLPFFNL 164

Human   185 FHTVLKQIAPEYFEKNEPYLEAACNDVDR-WPAPVPGKTLHLPIMGVVMKVRIP-TCHDKPGTTQ 247
            ::.:|.|:||.|||:....|..|...::| ||....||.|.||::....::.|| |...:..|..
  Fly   165 YYDILSQLAPRYFEEGTDVLRLASEQINRQWPGLRVGKPLQLPLLDCSYQICIPRTSSSRKSTAD 229

Human   248 -------IVQLTQQVDTNISVILPTVHEVDIFRCFCPVFLHSQMLWELVLLGEPLVVMAPSPSES 305
                   :...........:.:|.:|:|:::||....|......|||||:..||:||:..||::.
  Fly   230 GGIAGGAVESPPAMAACPAAKVLASVNEIELFRSLDFVMEQLYTLWELVITAEPIVVVGTSPADC 294

Human   306 SETVLALVNCISPLKYFSDFRPYFTIHDSEFKEYTTRTQAP---PSVILGVTNPFFAKTLQHWPH 367
            |..|..|:..|:||:|.::.|||||||||||:|:|....:.   |:.|||||||||.|.|:.|||
  Fly   295 SHMVQTLLAMIAPLEYCAEARPYFTIHDSEFREFTQECSSKTTLPACILGVTNPFFVKLLKDWPH 359

Human   368 IIRIGD--------------------------LKPTGEIPKQVKVKKLKNLKTLD---------S 397
            ::|:.|                          ...:.|:..::.:|...||....         |
  Fly   360 MLRLVDNQKNMQQQQHLLLGQKHARNIASATSFSSSTELGGRIALKSNTNLNGSSSSSNGSGDAS 424

Human   398 KPGVYTSYKPYLNRDEEIIKQLQKGVQQKRPSEAQSVILRRYFLELTQSFIIPLERYVASLMPLQ 462
            ..|:::.|:|||.:|:.:||::..|::.|||...|:.::||:.|||||||:||||||:|||||||
  Fly   425 SAGLHSKYRPYLKKDKALIKKVLLGMKTKRPEHVQTALIRRHLLELTQSFMIPLERYMASLMPLQ 489

Human   463 KSISPWKSPPQLRQFLPEEFMKTLEKTGPQLTSRIKGDWIGLYRHFLKSPNFDGWFKTRRKEMTQ 527
            |.|||:||.|....|..::|:.|||..||||||.:||||.||||.|.:||||.||:..|.:|:..
  Fly   490 KDISPFKSAPNANSFKLDDFLGTLETAGPQLTSPLKGDWKGLYRRFFRSPNFRGWYGARHRELQL 554

Human   528 KLEALHLEALCEEDLLLWIQKHTEVETVDLVLKLKNKL-LQADR--EHLPVKPDTMEKLRTHIDA 589
            .|:.|.|:||...:|..|.....|||.:|::||||.|| |..|:  :.......|.:::|..|:.
  Fly   555 TLQDLQLQALSVANLEHWAHDKQEVEIIDMILKLKQKLNLYGDKATQLEGNNGSTQQQIRAQIEC 619

Human   590 IILALPEDLQGIL 602
            :...||.||:.::
  Fly   620 MKGLLPPDLKNVV 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DENND6A	NP_689891.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..48
		Avl9	64..>201	CDD:430832	66/136 (49%)
		DENN	171..359	CDD:472208	72/199 (36%)
		SPA	270..373	CDD:454797	50/105 (48%)
CG3309	NP_572216.1	Avl9	49..>192	CDD:430832	68/147 (46%)
		SPA	270..368	CDD:454797	48/97 (49%)