Protein Alignment PDE12 and Pde12

DIOPT Version :9

• Sequence 1: NP_808881.3
• Gene: PDE12 / 201626
• HGNCID: 25386
• Length: 609
• Species: Homo sapiens
• Sequence 2: NP_848783.3
• Gene: Pde12 / 211948
• MGIID: 2443226
• Length: 608
• Species: Mus musculus
• Alignment Length: 609
• Identity: 538/609 - (88%)
• Similarity: 562/609 - (92%)
• Gaps: 1/609 - (0%)

Human     1 MWRLPGARAALRVIRTAVEKLSRAEAGSQTAAGAMERAVVRCVPSEPKLSLSFALADGSHKNMQR 65
            |||||| |:|||.:|:.||:.||||||:..|..||||||||||||||||||||||||||||||||
Mouse     1 MWRLPG-RSALRGVRSVVERRSRAEAGTHEAVRAMERAVVRCVPSEPKLSLSFALADGSHKNMQR 64

Human    66 DQSEPLGRVLSRIATNALKGHAKAAAAKKSRKSRPNASGGAACSGPGPEPAVFCEPVVKLYYREE 130
            ||||||||.||||||||||||||.||||||||:|.::||||||...||||...||||||||||||
Mouse    65 DQSEPLGRALSRIATNALKGHAKVAAAKKSRKNRAHSSGGAACEATGPEPVATCEPVVKLYYREE 129

Human   131 AVAEDVLNVDAWQDGAVLQIGDVKYKVERNPPAFTELQLPRYIMAGFPVCPKLSLEFGDPASSLF 195
            ||||||||||||||||||||||||||||||||.||||||||||||||||||||.:||||||||:|
Mouse   130 AVAEDVLNVDAWQDGAVLQIGDVKYKVERNPPTFTELQLPRYIMAGFPVCPKLGVEFGDPASSVF 194

Human   196 RWYKEAKPGAAEPEVGVPSSLSPSSPSSSWTETDVEERVYTPSNADIGLRLKLHCTPGDGQRFGH 260
            |||||.|||||||....|:|.|.||..|:|.||.|:||||||.||||||||:||||||:|||||.
Mouse   195 RWYKEVKPGAAEPGDSGPASSSHSSQPSAWIETGVDERVYTPCNADIGLRLRLHCTPGNGQRFGP 259

Human   261 SRELESVCVVEAGPGTCTFDHRHLYTKKVTEDALIRTVSYNILADTYAQTEFSRTVLYPYCAPYA 325
            ||||||:|.|||||||||||||||||||||||:.|||||||||||||||||||||||||||||||
Mouse   260 SRELESLCPVEAGPGTCTFDHRHLYTKKVTEDSFIRTVSYNILADTYAQTEFSRTVLYPYCAPYA 324

Human   326 LELDYRQNLIQKELTGYNADVICLQEVDRAVFSDSLVPALEAFGLEGVFRIKQHEGLATFYRKSK 390
            ||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||
Mouse   325 LELDYRQNLIQKELTGYNADLICLQEVDRAVFSDSLVPALEAFGLEGVFRIKQHEGLATFYRKSK 389

Human   391 FSLLSQHDISFYEALESDPLHKELLEKLVLYPSAQEKVLQRSSVLQVSVLQSTKDSSKRICVANT 455
            |.|||||||||.|||:||||||||||||.|.|.|||||||||||||:||||||.||||:||||||
Mouse   390 FRLLSQHDISFQEALKSDPLHKELLEKLALNPLAQEKVLQRSSVLQISVLQSTTDSSKKICVANT 454

Human   456 HLYWHPKGGYIRLIQMAVALAHIRHVSCDLYPGIPVIFCGDFNSTPSTGMYHFVINGSIPEDHED 520
            ||||||||||||||||.|||.||||||.|||||||||||||||||||||||||||:|||.|||||
Mouse   455 HLYWHPKGGYIRLIQMEVALVHIRHVSRDLYPGIPVIFCGDFNSTPSTGMYHFVISGSIAEDHED 519

Human   521 WASNGEEERCNMSLTHFFKLKSACGEPAYTNYVGGFHGCLDYIFIDLNALEVEQVIPLPSHEEVT 585
            ||||||||||:|.|:|.|||||||||||||||||||||||||||||||.||||||||||||||||
Mouse   520 WASNGEEERCSMPLSHCFKLKSACGEPAYTNYVGGFHGCLDYIFIDLNTLEVEQVIPLPSHEEVT 584

Human   586 THQALPSVSHPSDHIALVCDLKWK 609
            ||||||||||||||||||||||||
Mouse   585 THQALPSVSHPSDHIALVCDLKWK 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDE12	NP_808881.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	89..111		15/21 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..230		12/23 (52%)
		EEP	299..608	CDD:294334	288/308 (94%)
Pde12	NP_848783.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..111		14/20 (70%)
		EEP	298..607	CDD:294334	288/308 (94%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83954816
Domainoid	1	1.000	579	1.000	Domainoid score	I5534
eggNOG	1	0.900	-	-		E1_COG5239
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14272
Inparanoid	1	1.050	1093	1.000	Inparanoid score	I5066
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG56656
OrthoDB	1	1.010	-	-		D432310at33208
OrthoFinder	1	1.000	-	-		FOG0005860
OrthoInspector	1	1.000	-	-		oto124749
orthoMCL	1	0.900	-	-		OOG6_104860
Panther	1	1.100	-	-	LDO	PTHR12121
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1970
SonicParanoid	1	1.000	-	-		X4860
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.300