DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADGRE1 and Cirl

DIOPT Version :10

Sequence 1:XP_011526096.1 Gene:ADGRE1 / 2015 HGNCID:3336 Length:978 Species:Homo sapiens
Sequence 2:NP_001260807.1 Gene:Cirl / 35846 FlyBaseID:FBgn0033313 Length:1711 Species:Drosophila melanogaster


Alignment Length:1141 Identity:242/1141 - (21%)
Similarity:409/1141 - (35%) Gaps:330/1141 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    29 NTKGN-----NCRDSTLCPAYATCTNTVDSYYCACKQGFLSSNGQNHFKDPGVRCKDIDECSQSP 88
            |..||     ||    :.|...:..|:    .||.||.                |..:...|...
  Fly    57 NDHGNVEWSVNC----MFPKSLSVLNS----RCAHKQS----------------CGVLAATSMFG 97

Human    89 QPCGPNSSCKNLSGRYKCSCLDGFSS----PTGNDWV---------------------------- 121
            .|| |.:. |.|...|:|......|:    |:...||                            
  Fly    98 DPC-PGTH-KYLEAHYQCISAAQTSTTTNRPSPPPWVLSNGPPIFGNGSGLIHPPGVGAGAPPPP 160

Human   122 -----------PGKPGNFSCTDINECLTSSVCPEHSDCVNSMGSYSCSCQVGFISRNSTCEDIDE 175
                       .|.||.|           :|.|:|:...:|..|.|.:...|...:.....    
  Fly   161 RLPTLPGVVGISGNPGLF-----------NVPPQHTAVTHSTPSSSTTAVGGGRLKGGATS---- 210

Human   176 CSQSPQPCGPNSSCKNMSGRYKCSCLDGFSSPT---------GNDWI-PGKP-------GNF--- 220
                      .::.|:.:||:     ||...|.         |.|.. |.||       ||.   
  Fly   211 ----------TTTTKHPAGRH-----DGLPPPPQLHHHHNHHGEDTASPTKPSSKLPAGGNATSP 260

Human   221 -----------SCTDISESLTS--------------SVCPEHSDCVNSMGSYNCSCQVGFISRNS 260
                       |.||....||:              ||.|.:...|.::.:.|       ::...
  Fly   261 SNTRILTGVGGSGTDDGTLLTTKSSPNRPPGTAASGSVVPGNGSVVRTINNIN-------LNAAG 318

Human   261 ISSDVDE----CADPRACPEHAT---CNNT-VGNYSCFCNPGFESSSGHLSFQGL------KASC 311
            :|...||    |.     |.||.   .|.| ||:.:....||  .::|...::.:      .:..
  Fly   319 MSGGDDESKLFCG-----PTHARNLYWNMTRVGDVNVQPCPG--GAAGIAKWRCVLMKRIPDSGY 376

Human   312 EDIDECTEMCPINSTCTNTPGSYFCTCHPGFAPSNGQLNFTDQGVECRDIDECRQDPSTCGPNSI 376
            ::.|:     .|:||   ||           |||.|               :|..:.|:|.|...
  Fly   377 DEYDD-----DISST---TP-----------APSGG---------------DCLHNSSSCEPPVS 407

Human   377 CTNALGSYSCGCIAGFHP-NPEGSQKDGNFSCQRVLFKCKEDVI--PDNKQI---QQCQEGTAVK 435
            ..:.:..........:|| .|:.:|      |:.:.....|..:  .|:..|   ....|.|:.|
  Fly   408 MAHKVNQRLRNFEPTWHPATPDLTQ------CRSLWLNNLEMRVNQRDSSLISIANDMSEVTSSK 466

Human   436 PAYVSFCAQINNIF-SVLDKVCENKTTVVSLKNTTESFVPVL-------------KQISTWTKFT 486
            ..|.........|. :|.:|:..:|.|....:......:.:|             .|:|:|....
  Fly   467 TLYGGDMLVTTKIIQTVSEKMMHDKETFPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDLN 531

Human   487 KEETSSLATVFLESVE--SMTLA-------SFWKPSANITPAVRT-EYLDIESKVINKECSEENV 541
            .|:...:||..|..:|  :..||       |..:...||..:||. |...|:|.|:..:..:..:
  Fly   532 PEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPDSDQWPL 596

Human   542 TLDLVAKGDKMKIGCSTIEESESTETTGVAFVSFVGMESVLNERFFKDH---------------- 590
            :      .|::::..:.:.::.......:.|.:|..:||:|...:  ||                
  Fly   597 S------SDRIELPRAALIDNSEGGLVRIVFAAFDRLESILKPSY--DHFDLKSSRSYVRNTAIL 653

Human   591 --QAPLTTSEIKLK---MNSRVVGGIMTGEKKDGFSDPIIYTLENIQPKQKFERPICVSWSTDVK 650
              .:.:...||:.:   :||:|:...:...:....|.||..||:::: .:....|.||.|  :..
  Fly   654 SNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQPITLTLKHLK-TENVTNPTCVFW--NYI 715

Human   651 GGRWTSFGCVILEASETYTICSCNQMANLAVIM------ASGELTM-DFSLYIISHVGIIISLVC 708
            ...|::.||.:...:.|:::||||.:.|.|::|      .....|| |.::.|..::.|.|.:|.
  Fly   716 DHAWSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNMRIFIYISIGICVVF 780

Human   709 LVLAIATFLLCRS--IRNHNTYLHLHLCVCLLLAKTLFLAGIHKTDNKMGCAIIAGFLHYLFLAC 771
            :|:|:.|..|...  :::..|.::..:.:|||..:.|||.||.:|:..:.|..|..|||...|:.
  Fly   781 IVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSG 845

Human   772 FFWMLVEAV----------ILFLMVRNLKVVNYFSSRNIKMLHICAFGYGLPMLVVVISASVQPQ 826
            ..|...||.          :|..:.:..||..|:           ...|||.:.||.||..:.|.
  Fly   846 TAWFCYEAFHSYSTLTSDELLLEVDQTPKVNCYY-----------LLSYGLSLSVVAISLVIDPS 899

Human   827 GYGMHNRCWL-NTETGFIWSFLGPVCTVIVINSLLLTWTLWILRQRLSSVNAEVSTLKDTRLLTF 890
            .|..::.|.| .....|..:|:.|| .|..:.::..|:..||:..|.|...  :.|.:.|||.:.
  Fly   900 TYTQNDYCVLMEANALFYATFVIPV-LVFFVAAIGYTFLSWIIMCRKSRTG--LKTKEHTRLASV 961

Human   891 K-----AFAQLFILGCSWVLGIFQI------GPVAGVMAYLFTIINSLQGAFIFLIHCLLNGQVR 944
            :     :|..|.:|...|....|.:      ...|.|..|.|...|:|.|.:||:.||:.|.::|
  Fly   962 RFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIR 1026

Human   945 EEYKR------WITGKTKPSSQSQTSRILLSSMPSA 974
            .||::      |:....:.|..|.:|.|:..:.|:|
  Fly  1027 REYRKYVRQHAWLPKCLRCSKTSISSGIVTGNGPTA 1062

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADGRE1XP_011526096.1 TM helix 3 758..785 CDD:320555 9/36 (25%)
TM helix 4 802..822 CDD:320555 7/19 (37%)
TM helix 5 839..862 CDD:320555 5/22 (23%)
TM helix 6 886..911 CDD:320555 7/35 (20%)
TM helix 7 915..940 CDD:320555 10/24 (42%)
EGF_CA 33..62 CDD:238011 9/33 (27%)
EGF_CA 80..114 CDD:214542 8/33 (24%)
EGF_CA 132..171 CDD:214542 7/38 (18%)
EGF_CA 172..206 CDD:214542 5/33 (15%)
EGF_CA 224..260 CDD:214542 8/49 (16%)
EGF_CA 264..297 CDD:214542 12/40 (30%)
EGF_CA 313..>342 CDD:214542 6/28 (21%)
EGF_CA 360..393 CDD:214542 4/32 (13%)
GPS 638..687 CDD:197639 15/54 (28%)
7tmB2_EMR 691..953 CDD:320555 78/291 (27%)
TM helix 1 693..718 CDD:320555 7/24 (29%)
TM helix 2 727..749 CDD:320555 8/21 (38%)
CirlNP_001260807.1 Gal_Rha_Lectin_dCirl 22..113 CDD:438687 19/81 (23%)
GAIN 451..682 CDD:465137 43/238 (18%)
GPS 705..752 CDD:197639 15/48 (31%)
7tmB2_CELSR_Adhesion_IV 763..1035 CDD:320557 77/285 (27%)
TM helix 1 765..790 CDD:320557 7/24 (29%)
TM helix 2 801..823 CDD:320557 8/21 (38%)
TM helix 3 832..859 CDD:320557 8/26 (31%)
TM helix 4 875..895 CDD:320557 9/30 (30%)
TM helix 5 913..942 CDD:320557 8/29 (28%)
TM helix 6 960..987 CDD:320557 5/26 (19%)
TM helix 7 997..1022 CDD:320557 10/24 (42%)
Herpes_TAF50 <1219..1365 CDD:308764
Blue background indicates that the domain is not in the aligned region.

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