DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADGRE1 and mthl1

DIOPT Version :9

Sequence 1:XP_011526096.1 Gene:ADGRE1 / 2015 HGNCID:3336 Length:978 Species:Homo sapiens
Sequence 2:NP_001285340.1 Gene:mthl1 / 32637 FlyBaseID:FBgn0030766 Length:676 Species:Drosophila melanogaster


Alignment Length:265 Identity:67/265 - (25%)
Similarity:115/265 - (43%) Gaps:47/265 - (17%)


- Green bases have known domain annotations that are detailed below.


Human   701 GIIISLVCL-VLAIATFLLCRSIRNHNTYLHLHLC--VCLLLAKTLFLAGIHKTDNKM-----GC 757
            ||::|:|.| ...:|.|||  ...:|..:....:|  .|||..|  .|..|.:..:.:     .|
  Fly   335 GILVSIVFLSATLVAGFLL--PAVHHALHWRCQICYVTCLLFGK--ILLAIEELSSSLQPGSAAC 395

Human   758 AIIAGFLHYLFLACFFWMLVEAVILFLMVRNLKVVNYFSSRNIKMLH---ICAFGYGLPMLVVVI 819
            ..:|..:.:.|||.|||:......::...|:.:..:.  .||.:.|.   ...:.:|.|:|:..:
  Fly   396 HTLAITMQFFFLAAFFWLNTMCFNIWWTFRDFRPSSL--ERNQEALRRYLYSLYAWGGPLLITFV 458

Human   820 SASVQ--PQ------GYGMHNRCWLNTETGFIWS-FLGPVCTVIVINSLL-------LTWTLWIL 868
            :|.|.  |:      |:| ...||.:.....|:: |.||:..::..|..|       ||..||  
  Fly   459 AACVDQLPETTLLRPGFG-QLYCWFDNRNLSIFAYFYGPIGLLLCANIALFVSTTHQLTCGLW-- 520

Human   869 RQRLSSVNAEVSTLKDTRLLTFKAFAQLFILGCSWVLGIFQ--IGPVAGVMAYLFT-IINSLQGA 930
                  ...:|.:..:...|.......:.::|.:|:..|..  :|...||  :.|| :||:|||.
  Fly   521 ------KRDDVKSSSEKSALGRVCLKLVVVMGVTWIADILSWLVGGPHGV--WFFTDLINALQGV 577

Human   931 FIFLI 935
            |||::
  Fly   578 FIFIV 582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADGRE1XP_011526096.1 EGF_CA 33..62 CDD:238011
EGF_CA 80..114 CDD:214542
EGF_CA 132..171 CDD:214542
EGF_CA 172..206 CDD:214542
EGF_CA 224..260 CDD:214542
EGF_CA 264..297 CDD:214542
EGF_CA 313..>342 CDD:214542
EGF_CA 360..400 CDD:284955
GPS 638..687 CDD:197639
7tm_2 691..932 CDD:278432 64/260 (25%)
mthl1NP_001285340.1 7tm_4 329..579 CDD:304433 64/260 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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