Protein Alignment SPNS3 and spin

DIOPT Version :10

• Sequence 1: NP_872344.3
• Gene: SPNS3 / 201305
• HGNCID: 28433
• Length: 512
• Species: Homo sapiens
• Sequence 2: NP_524823.1
• Gene: spin / 45380
• FlyBaseID: FBgn0086676
• Length: 630
• Species: Drosophila melanogaster
• Alignment Length: 531
• Identity: 209/531 - (39%)
• Similarity: 292/531 - (54%)
• Gaps: 66/531 - (12%)

Human    14 PGGLQGQSPG-PGRQCPPPITPTSWSLPPWRAYVAAAVLCYINLLNYMNWFIIAGVLLDIQEVFQ 77
            |.|.....|| |    |..:.|:..|......:....|||::||:|||:.|.|||||.|::..|.
  Fly    86 PLGEHHHIPGIP----PSAVVPSRLSSVGRSQWFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFD 146

Human    78 ISDNHAGLLQTVFVSCLLLSAPVFGYLGDRHSRKATMSFGILLWSGAGLSSSFISPRYSWLFFLS 142
            |.::.|||||||||...::.||:|||||||:||...|:.|:.|||...|..||:. ::.| |...
  Fly   147 IGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMK-QFGW-FIAF 209

Human   143 RGIVGTGSASYSTIAPTVLGDLFVRDQRTRVLAVFYIFIPVGSGLGYVLGSAVTMLTGNWRWALR 207
            |.:||.|.|||||||||::.||||.|.|:::||:||..|||||||||::||....|..:||||||
  Fly   210 RALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWALR 274

Human   208 VMPCLEAVALILLILLVPDPPRGAAETQGEGAVGGFRSSWCEDVRYLGKNWSFVWSTLGVTAMAF 272
            |.|.|..|| :.||||:.||.||    ..||:.....:::.:|::.|.:|.||:.||.|.|.:||
  Fly   275 VTPILGIVA-VFLILLIKDPVRG----HSEGSHNLEATTYKQDIKALVRNRSFMLSTAGFTCVAF 334

Human   273 VTGALGFWAPKFLLEARVVHGLQPPCFQEPCSNPD-SLIFGALTIMTGVIGVILGAEAARRYKKV 336
            |.|||.:|.|.|     :..|::.....|.....| :..||.:|::.|::||.||:..::...|.
  Fly   335 VAGALAWWGPSF-----IYLGMKMQPGNENIVQDDVAFNFGVITMLAGLLGVPLGSFLSQYLVKR 394

Human   337 IPGAEPLICASSLLATAPCLYLALVLAPTTLLASYVFLGLGELLLSCNWAVVADILLSVVVPRCR 401
            .|.|:|:|||..||.:||.|..|.:|..:..:.:|..:..|:|.|:.|||:||||||.||||..|
  Fly   395 YPTADPVICAFGLLVSAPLLTGACLLVNSNSVGTYALIFFGQLALNLNWAIVADILLYVVVPTRR 459

Human   402 GTAEALQITVGHILGDAGSPYLTGLISSVL----------------------------------- 431
            .||||.||.:.|.|||||||||.|.||..:
  Fly   460 STAEAFQILISHALGDAGSPYLVGAISEAIMKHLHKNPSDSGLTTELRSMSQVAGSAISNATQVI 524

Human   432 -----------RARRPDSY--LQRFRSLQQSFLCCAFVIALGGGCFLLTALYLERDETRAWQPVT 483
                       |:.....|  :::|..||.:....:||..|||..|:.||.::.:|:..|.:.:.
  Fly   525 AEATTSLMETARSSASQEYSDVEQFEGLQYALFSTSFVEVLGGIFFIFTACFIIKDKYNATRGLQ 589

Human   484 GTPDSNDVDSN 494
            |...:..|.|:
  Fly   590 GDQGAQAVRSS 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPNS3	NP_872344.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		5/16 (31%)
		MFS_spinster_like	49..465	CDD:340886	193/464 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..512		3/14 (21%)
spin	NP_524823.1	MFS_spinster_like	117..571	CDD:340886	193/465 (42%)