Protein Alignment FLCN and BHD

DIOPT Version :9

• Sequence 1: NP_001340158.1
• Gene: FLCN / 201163
• HGNCID: 27310
• Length: 597
• Species: Homo sapiens
• Sequence 2: NP_648090.1
• Gene: BHD / 38793
• FlyBaseID: FBgn0261111
• Length: 460
• Species: Drosophila melanogaster
• Alignment Length: 593
• Identity: 154/593 - (25%)
• Similarity: 243/593 - (40%)
• Gaps: 152/593 - (25%)

Human     1 MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGDGNEDSPGQGEQAEEEEGGIQMNSRMRAHSPAE 65
            |||::|||||||.|||..:|||:.|.                                  .:..|
  Fly     1 MNAVIALCHFCEAHGPCAIFCTQTLR----------------------------------DTKLE 31

Human    66 GASVESSSPGPKKSDMCEGCR-SLAAGHPGYISHDKETSIKYVSHQHPSHPQLFSIVRQACVRSL 129
            ..|:|..:     ...|..|. |:...:....|.|.|:...:||.:....|::.|:|:||.|.||
  Fly    32 DLSLEQQT-----QKTCSACNYSMGKNNNAIYSRDTESGATFVSTKVAVLPEVASLVKQAAVLSL 91

Human   130 SCECRESAVAALTCWFFCMLQVCPGREGP-IFFGDEQHGFVFSHTFFIKDSLARGFQRWYSIITI 193
            |.....|                  ::|. :||||...|.:.||||.:.|..|||:.:.:|||.:
  Fly    92 SNGTDAS------------------KDGEFVFFGDSSRGHILSHTFRVSDLQARGYSQLFSIIVL 138

Human   194 MMDRIYLINSWPFLLGKVRGIIDELQGKALKVFEAEQFGCPQRAQRMNTAFTPFLHQRNGNAARS 258
            |.|:.:|:|..|||...::.:..|||..|.|..|.|:....:|.:|::.|  .||..    .:|:
  Fly   139 MKDKYFLLNIKPFLAEHLKKVSSELQAAAKKTKETEEQTYSERQRRLSGA--QFLMP----TSRA 197

Human   259 LTSLTSDDNLWACLHTSFAWLLKACGSR-LTEKLLEGAPTEDTLVQMEKLADLEEESESWDNSEA 322
            |..||.:::::|.||:.|:|||.| ||| |||.:..|
  Fly   198 LLELTGEEHIFAQLHSHFSWLLLA-GSRFLTEHVTFG---------------------------- 233

Human   323 EEEEKAPVLPESTEGRELTQGPAE-----SSSLSGCGSWQPRKLPVFKSLRHMRQVLGAPSFRML 382
                ..|.||..:.||.    ||:     ||:|....|.....|..|.||||::.|:....|..:
  Fly   234 ----NLPWLPPQSSGRP----PAQRLTYNSSTLPMIESIDDPDLEEFFSLRHLKSVVRKEEFATV 290

Human   383 AWHVLMGNQVIWKSRDVDLVQSAFEVLRTMLPVGCVRIIPYSSQYEEAYRCNFLGLSPHVQIPPH 447
            .:..|.|.:::.:. |..........|:.:||.....::...:|::                  |
  Fly   291 CYCALTGVKIVVRG-DPRKTFRFMVCLKKLLPEPMHNLMRIDAQHQ------------------H 336

Human   448 VLSSEFAVIVEVHAAARSTLHPVGCEDDQSLSKYEFV--------VTSGSPVAADRVGPTILNKI 504
            .:|||:.:|    :.:.....|:.   ..|:.:.:|:        |:...|....|..|.::.|:
  Fly   337 SISSEYKII----SVSNDIAVPMA---SSSVYRIDFLDKHVNGHEVSVKWPGELPRKLPDLMVKL 394

Human   505 EAALTNQNLSVDVVDQCLVCLKEEWMNKVKVL--FKFTKVDSRPKEDTQKLLSILGASEEDNVKL 567
            ..|:..:|.:..|:::....|.|||.|||..|  .|.|.|..       ||..:||....|. .:
  Fly   395 LKAVEEKNFTELVLNKQTKVLIEEWKNKVTCLNHAKSTSVQG-------KLKKVLGVQPHDQ-PI 451

Human   568 LKFWMTGL 575
            :.:|.|.|
  Fly   452 INYWSTHL 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FLCN	NP_001340158.1	Folliculin	106..283	CDD:314549	59/177 (33%)
		Folliculin_C	367..581	CDD:318824	47/219 (21%)
BHD	NP_648090.1	Folliculin	67..221	CDD:288541	59/177 (33%)
		Folliculin_C	275..459	CDD:293297	46/217 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159233
Domainoid	1	1.000	99	1.000	Domainoid score	I7118
eggNOG	1	0.900	-	-		E1_KOG3715
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14583
Inparanoid	1	1.050	155	1.000	Inparanoid score	I4320
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56199
OrthoDB	1	1.010	-	-		D593097at33208
OrthoFinder	1	1.000	-	-		FOG0005615
OrthoInspector	1	1.000	-	-		oto90886
orthoMCL	1	0.900	-	-		OOG6_106566
Panther	1	1.100	-	-	LDO	PTHR31441
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5257
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770