Protein Alignment CEP112 and Cep112

DIOPT Version :10

• Sequence 1: NP_001340058.1
• Gene: CEP112 / 201134
• HGNCID: 28514
• Length: 956
• Species: Homo sapiens
• Sequence 2: XP_038941574.1
• Gene: Cep112 / 287776
• RGDID: 1564168
• Length: 1032
• Species: Rattus norvegicus
• Alignment Length: 982
• Identity: 818/982 - (83%)
• Similarity: 890/982 - (90%)
• Gaps: 28/982 - (2%)

Human     1 MEVGSEEEKWEKLDAEFDHFVVDMKPFVLKLPHRTERQRCALWIRKLCEPSGTGAGIMGRKNRNL 65
            ||:|||||||||||||||||||||||||||||||:|||||||||||||||||||||:||||||||
  Rat    53 MEMGSEEEKWEKLDAEFDHFVVDMKPFVLKLPHRSERQRCALWIRKLCEPSGTGAGLMGRKNRNL 117

Human    66 YAKLLLHMLKRGALEGPFTHRPEPGTLKILPSYMSIYFDEPNPARAKGSSPEGLPAWVLGELETS 130
            |||||||||:||.|||||||||||||||:|||||||||||||.|::|.||||.||.||:||||..
  Rat   118 YAKLLLHMLRRGVLEGPFTHRPEPGTLKVLPSYMSIYFDEPNSAQSKDSSPEKLPDWVMGELEPG 182

Human   131 EHKLNESWKLSSGEDNTLVQSPTDVYSREQYTGKLRVRSHSLSPTHREDGQNITPKIC------- 188
            |.:|::||:||.||:|.|:.|.:|.: |||||||||:||||:|||.|||.|:||.|||
  Rat   183 ERRLSDSWQLSCGEENALLLSASDAH-REQYTGKLRMRSHSVSPTDREDRQHITSKICCMNENEF 246

Human   189 -------------------EVYSKKSPVSLDDSDIEARLNSWNLGIENPRYLRQKPIPVSLQMTP 234
                               |::.||||:||||||||.|||||||||||||||||||:|||| |||
  Rat   247 KNKELLGHQHKTFLLTNFKEIHPKKSPISLDDSDIEVRLNSWNLGIENPRYLRQKPLPVSL-MTP 310

Human   235 KFSLRKSSSFHDDHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELK 299
            |.|||.||:.||||||||:.|||||||||||||||.|||||||:||||:|||||||||||:||||
  Rat   311 KVSLRNSSNLHDDHFLSRMHEKELDMKTKMMEAKFSEEKLKLQKKHDAEVQKILERKNNELEELK 375

Human   300 TLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAV 364
            .||:.||.|||||:||||||||.|||||||||||||:||.||||||||||||||||||||||:||
  Rat   376 ILYKKKQTETEETVRKLEKKVQILIRDCQVIRETKENQITELKKICEQSTESLNNDWEKKLHSAV 440

Human   365 AEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSN 429
            ||||:|||:|||.|||.||||||||||||:|||.:||.||||||||||:||.|||||.|||||||
  Rat   441 AEMEKEKFELQKHHTETIQELLEDTNVRLSKMEGDYMVQTQSTNHMIKDLEGRVQQLMGEAENSN 505

Human   430 LQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQ 494
            ||||||.|||.|||||||||||||||:|.|:|.||.||:|||||||||:|||:||||:|||:|:|
  Rat   506 LQRQKLTQEKLELERCYQITCSELQELKTRQNLLHTEKEHLVNDYEQNVKLLKTKYDSDINILRQ 570

Human   495 EHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQS 559
            |||||.||.|.:|||||||:.|||||:||||||||||::|||:||.|||:|||:|||:|.|:|:|
  Rat   571 EHALSTSKTSVVIEELEQNIRQLKQQVQESELQRKQQVKDQEDKFHMEKNHLKYIYEEKVHELKS 635

Human   560 ELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKE 624
            ||||.|||.|:||||||||||||||||.|||||||||||||||||||||||||:.|||||::|||
  Rat   636 ELDKEKEDAQRKIHKFEEALKEKEEQLGRVTEVQRLQAQQADAALEEFKRQVEVTSEKVYSDMKE 700

Human   625 QMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVR 689
            |||||||||:|||||||||||||||||||.|||||||||||||||||||||||||||||||||||
  Rat   701 QMEKVEADLSRSKSLREKQSKEFLWQLEDARQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVR 765

Human   690 DHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGL 754
            |||||:||||.|||||||||||||||.|||||||||||||||||||||||||||.||||||||||
  Rat   766 DHEREVENLENQLRAANMEHENQIQESKKRDAQVIADMEAQVHKLREELINVNSHRKQQLVELGL 830

Human   755 LREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSS 819
            |||||||||.|:||..|.|||||||::|:|||||||||||||||||||:||||||||||||||||
  Rat   831 LREEEKQRAARDHETAVKKLKAESERVKMELKKTHAAETEMTLEKANSRLKQIEKEYTQKLAKSS 895

Human   820 QIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVR 884
            ||||||||||||||||:|:||||||||||||.|||||||:|||||||||||.||||||.||||||
  Rat   896 QIIAELQTTISSLKEESSRQQLAAERRLQDVIQKFEDEKQQLIRDNDQAIKALQDELETRSNQVR 960

Human   885 CAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEEL 949
            .|||||||||||:|||:.|||||||||.|||||||||||||||||||||||||||||||||||||
  Rat   961 SAEKKLQHKELEAQEQMMYIRQEYETKFKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEEL 1025

Human   950 TTYQGRR 956
            ||||.||
  Rat  1026 TTYQSRR 1032

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CEP112	NP_001340058.1	DUF4485	13..98	CDD:464345	79/84 (94%)
		Smc	302..>934	CDD:440809	548/631 (87%)
Cep112	XP_038941574.1	DUF4485	65..150	CDD:464345	79/84 (94%)
		SMC_prok_B	<323..1014	CDD:274008	600/690 (87%)
		Smc	635..>969	CDD:440809	303/333 (91%)