DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rps6ka1 and JIL-1

DIOPT Version :9

Sequence 1:	NP_001365809.1	Gene:	Rps6ka1 / 20111	MGIID:	104558	Length:	741	Species:	Mus musculus
Sequence 2:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster

Alignment Length:	718	Identity:	257/718 - (35%)
Similarity:	368/718 - (51%)	Gaps:	55/718 - (7%)

- Green bases have known domain annotations that are detailed below.

Mouse    28 SQTLPGPGPGPQQDSDEAILKEI----SITHHVKAGSEKA-DPSQFELLKVLGQGSFGKVFLVRK 87
            |..:|.....|....:||..:::    .:.::||..|::| ..:.|::::|||.|::|:||||||
  Fly   216 SYAMPTSNSTPLDLDNEAHQRDLEAVTDLKYYVKLYSDEAVSLNDFKIIRVLGTGAYGRVFLVRK 280

Mouse    88 VTRPDSGHLYAMKVLKKATL--KVRDRVRTKMERDILADV-NHPFVVKLHYAFQTEGKLYLILDF 149
            :||.|:|.|||||||.|.|:  |.:....||.||.:|..: .:||:|.||||||:..||||:|||
  Fly   281 LTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDF 345

Mouse   150 LRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGL 214
            ..||:|||.|.....|.|..|:.|:||:.|.|:.||.|||||||:|.||||||.||||.|:||||
  Fly   346 ANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGL 410

Mouse   215 SK-EAIDHEKKAYSFCGTVEYMAPEVVNR--QGHTHSADWWSYGVLMFEMLTGSLPFQGKD---- 272
            || ...::|.:|:|||||:||||||::..  .||..:.||||.|||.||:|||:.||...|
  Fly   411 SKILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDGQVQ 475

Mouse   273 RKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFYSTIDWNKLYR 337
            :.|....|.|.:..:|...|..|:..:..:.::||..|||.....|.|||.|.|::.|:|.:|..
  Fly   476 QSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQELRT 540

Mouse   338 REIKPPFKPAVAQPDDTFYFDTEFTSRTPRDSP-GIPPSAGAHQLFRGFSFVATGLMEDDGKPRT 401
            :..|.|:||.:...||...|..|||.:.|.|.. ..|||  ..:||||:::||...:|...:..
  Fly   541 KRRKAPYKPTLTAEDDVQNFSNEFTDQVPEDPECDAPPS--RIRLFRGYTYVAPEHLEQMRRDN- 602

Mouse   402 TQAPLHSVVQQLHG--KNL-VFSDGYVVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPS 463
                 |..:|..:.  :|: ...|...:......|:|..|...|..:|::.:..|:|..||..||
  Fly   603 -----HCEIQYFNTGLQNIPCRPDDLELGTRTSNGAYGTCHFVVDSSTDLVFLAKIIPLSKFRPS 662

Mouse   464 EE---IEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTI 525
            |.   |...|....|.||::....:.:....::|.|.:.|.||...| |....|.||   :...:
  Fly   663 EVDALISCALDTTNHKNIVSYHGTFREKCETWIVMEYLSGPELTASI-RMDEDSCRE---IFLQL 723

Mouse   526 SKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPE 590
            ...|.::||:..:|.||||.||::  |:.....:::.|||.|............|.||.::..||
  Fly   724 VMAVRHIHSKHFIHGDLKPENIMF--ENREDRTVKLIDFGSACYNNRFKSWKDKPRYTLDYAPPE 786

Mouse   591 VLKRQG---YDEGCDIWSLGILLYTMLAGYTPFANGPSDTP------EEILTRIGSGKFTLSGGN 646
            :|....   |....||:.||..|||||.|:.|:.....|..      .|:..|:..|.|......
  Fly   787 MLADANLVTYSPAVDIYGLGATLYTMLVGHRPYRQNEDDVDHSAAAHHELRKRMRRGTFNQRSMR 851

Mouse   647 WNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWITQKDK-------LPQS---QLSHQDLQLVK 701
            |.:.|...:.|||..|..||..|.|...:|...|:.....       |||.   .||...::...
  Fly   852 WESASPAFRHLVSWCLQRDPADRPTLSDILDSEWLQYGSNDPDVDIILPQQMVVDLSEDTMEQPT 916

Mouse   702 GAM 704
            |.|
  Fly   917 GGM 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rps6ka1	NP_001365809.1	STKc_RSK_N	72..388	CDD:270734	156/326 (48%)
Rps6ka1	NP_001365809.1	STKc_RSK1_C	422..712	CDD:271077	85/305 (28%)
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	134/268 (50%)
		STKc_MSK_N	266..533	CDD:270735	134/266 (50%)
		S_TK_X	532..591	CDD:214529	22/60 (37%)
		S_TKc	632..886	CDD:214567	76/259 (29%)
		PKc_like	632..885	CDD:304357	76/258 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830539
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740