DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MARK2 and AMPKalpha

DIOPT Version :9

Sequence 1:	XP_011543091.1	Gene:	MARK2 / 2011	HGNCID:	3332	Length:	808	Species:	Homo sapiens
Sequence 2:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	669	Identity:	205/669 - (30%)
Similarity:	309/669 - (46%)	Gaps:	157/669 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    60 SATSADEQP--HIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNS-SSLQKLFREV 121
            :|.||:.||  .||:|.|..|:|.|.|.|||:..|.:|..:|||||:::.::.| ..:.|:.||:
  Fly    13 AAGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREI 77

Human   122 RIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 186
            :.:|:..||:|:||::||.|...::::|||.||||:|||:|.||:::|.:||..|:||:|.|.||
  Fly    78 QNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYC 142

Human   187 HQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 251
            |:..|||||||.||||||.:|::||||||.||....|..|.|.||||.|||||:..||.|.||||
  Fly   143 HRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEV 207

Human   252 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLE 316
            |:||.|||||.|:.|:||||.:::..|..::..|.:.||.|::....||:.:.|.::|.||..:|
  Fly   208 DIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIE 272

Human   317 QIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL- 380
            :|.|..|            :.:.||.|..|...|            |||       .|:.||.:
  Fly   273 EIKKHEW------------FQKDLPAYLFPSSIE------------QDS-------NVIDTYAVA 306

Human   381 -----LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS 440
                 .|.|.:|:....:      |.|        |..::..:.......:||:|.||......:
  Fly   307 EVCTKFGVKETEVHNSLL------SGD--------PHDQLAIAYHLIIDNKRFADDAANQINEIN 357

Human   441 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRN 505
            |.:                      .|.|....|..|:|                   .::....
  Fly   358 NFF----------------------VAGSPPPPPPPPVP-------------------QSSMDHQ 381

Human   506 SPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTE 570
            :||        |::..|      .|:.||:.:|:..                  |..|.|.|
  Fly   382 APL--------ATVTVG------GGTSASSGTATPV------------------PPVAGGTP--- 411

Human   571 SNCEVP-RPSTAPQRV-PVASPS-AHNISSSGGA--PDRTNFPRGVS--SRSTFHAG-------- 620
             :..:| ||.  |:|: |:.... |.::.:|||.  |::|  .||.:  .|:.:|.|
  Fly   412 -SSTIPIRPH--PERIAPMRDRQLAMSVQTSGGGAFPEKT--ARGGTPIKRAKWHLGIRSQSKPN 471

Human   621 --QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVR---RNLSFRFARRNLNEPE 680
              .|...|..:.|.|.....:|......|:......|||.:.:..:   ::....|.....:|.|
  Fly   472 DIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDAKSYLLDFKSLTNDEVE 536

Human   681 SKDRV--ETLRPHVVGSGG 697
            ..|.|  |:|.|..:...|
  Fly   537 QGDDVIMESLTPPPLSVSG 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MARK2	XP_011543091.1	STKc_MARK	72..324	CDD:270974	122/252 (48%)
		S_TKc	73..324	CDD:214567	122/251 (49%)
		UBA_MARK2	342..383	CDD:270589	9/46 (20%)
		MARK2_C	709..807	CDD:213386
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	125/266 (47%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	16/83 (19%)
		AMPKA_C	457..580	CDD:213378	21/99 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910