Protein Alignment MARK2 and Tssk

DIOPT Version :10

• Sequence 1: NP_001034558.2
• Gene: MARK2 / 2011
• HGNCID: 3332
• Length: 788
• Species: Homo sapiens
• Sequence 2: NP_650732.1
• Gene: Tssk / 42233
• FlyBaseID: FBgn0038630
• Length: 302
• Species: Drosophila melanogaster
• Alignment Length: 310
• Identity: 99/310 - (31%)
• Similarity: 157/310 - (50%)
• Gaps: 27/310 - (8%)

Human    30 SKSNMIRG------RNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILT---GKEVAVKIID 85
            ||.|...|      |:|...|..|   ..|.:...||:|::|.|..|.:...   |..:|.||||
  Fly     2 SKYNSSAGIRQLGTRSSDVDALAQ---RGYNVGHKIGEGSYATVITAGYADDHGHGVHLACKIID 63

Human    86 KTQLNSSSLQKLF-REVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKE 149
            |.:..:..:.|.| ||:.|:..::|.||:::..:::....:::.|.||..|::..::...|.:.|
  Fly    64 KAKAPTDFVNKFFPRELEILTKIDHSNIIQIHSILQRGPKIFIFMRYAENGDLLSHIKRSGPIDE 128

Human   150 KEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGN----KLDTFC 210
            |:::..|.|:..|::|.|...|.|||||.||:||...:|||:|||||:......|    |.:|:|
  Fly   129 KQSKIWFFQMSKALKYLHNLDIAHRDLKCENILLSKRLNIKLADFGFARYCRDDNGREMKSETYC 193

Human   211 GSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKEL----RERVLRGKYRIPF 271
            ||..|||||:..|:.||....|.|||||||:.:::..:|||..||.:|    |.|....:.::..
  Fly   194 GSAAYAAPEVVCGRPYDPKLADAWSLGVILFIMMNAKMPFDDSNLTKLLEDQRNRKFAFRRKLQE 258

Human   272 YMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLP 321
            .:|...:..:...|......|..|.:|:...|:....|..      .|:|
  Fly   259 TISAQAKATVSVLLEPEAHARWNLREILNCAWLRTVEESQ------TPIP 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARK2	NP_001034558.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46		7/21 (33%)
		STKc_MARK	52..304	CDD:270974	87/263 (33%)
		UBA_MARK2	322..363	CDD:270589	99/310 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	373..632
		MARK2_C	689..787	CDD:213386
Tssk	NP_650732.1	STKc_TSSK-like	27..291	CDD:270982	87/263 (33%)