Protein Alignment MARK2 and KP78a

DIOPT Version :10

• Sequence 1: NP_001034558.2
• Gene: MARK2 / 2011
• HGNCID: 3332
• Length: 788
• Species: Homo sapiens
• Sequence 2: NP_650066.1
• Gene: KP78a / 41362
• FlyBaseID: FBgn0026064
• Length: 705
• Species: Drosophila melanogaster
• Alignment Length: 722
• Identity: 304/722 - (42%)
• Similarity: 413/722 - (57%)
• Gaps: 127/722 - (17%)

Human     2 SSARTPLPTLNERDTEQPT------LGHLDSKPSSKSNMIRGRNSATSADEQPHI-----GNYRL 55
            :|..|.||.       .||      ||  |...|||:         |.:..|.::     |.|::
  Fly    54 TSNATALPA-------TPTVAAGQDLG--DGACSSKN---------TDSKFQSYVNGNGNGVYKI 100

Human    56 LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120
            :||:|||||||||||.|:.||:|||:|:|||||||:|:.|||:|||:|||:|||||||:||:|||
  Fly   101 IKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVKIMKLLNHPNIVRLFQVIE 165

Human   121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDA 185
            :|:||||||||||.||:||:||.:|||:|::||..|||:|||:||||.||:|||||||||||||.
  Fly   166 SERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCHSKFVVHRDLKAENLLLDQ 230

Human   186 DMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 250
            .||||||||||.|.|....:|:||||||||||||||.|:||.|||||.|||||:|||||||||||
  Fly   231 HMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVDAWSLGVVLYTLVSGSLPF 295

Human   251 DGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGH-EDDELK 314
            ||..||||||||||||||:|:|:|.|||||::|||:|||:||.:|..:|.|:|:|:|| |.|.|:
  Fly   296 DGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSAVMSDKWINLGHDESDRLR 360

Human   315 PYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRP 379
            |:.|...:.:|..|.:|::|||:.|.:::.|:.||.::::..||:|||.........:...:..|
  Fly   361 PFREKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYMLLGVAKPRSSNRSTKPEAIP 425

Human   380 SADLTNSSAPSP-----------SHKVQRSVSANPKQRRFSDQAAG-PAIPTSNSYSKKTQSNNA 432
            :.|||..:..||           :| |..::..||...  |..|:| |..|         :..||
  Fly   426 TVDLTTPAVSSPLPNITTPTVTIAH-VTLALDKNPPIH--SSSASGRPIAP---------RLANA 478

Human   433 ENKRPEEDRESGRKASSTAKVPA-SPLPGLERKKTTPT-----PSTNSVLSTSTNRSRNSPLLER 491
            .| .|.....:|..|..|.:.|| :|    .||.|..|     |..:|:..|        |..:|
  Fly   479 PN-TPTSTPPTGPPAKPTRRTPARTP----ARKATNHTSGQGRPEPSSLPHT--------PQSKR 530

Human   492 ASLG---QASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLP--PTES 551
            ||..   :.::.:.:..|......|:|           |.:.|..::.:  ||:|.|..  || :
  Fly   531 ASANMDVKPTLLSAQRQLAQTQKLANT-----------PPRFQYPVAQT--PNQAQGSSRRPT-T 581

Human   552 NCEVPRPSTAPQRVPVASPSAHNISS---SGGAPDRTN---FPRGVSSRSTFHAGQLRQVR---- 606
            ..|...|:..|..||.:......:..   .|||.::|:   |.|...:|:|||.||.|..:
  Fly   582 LYEKAEPAVTPLLVPKSPAMGARLLERIPGGGAVEKTSDKPFTRQNVARATFHFGQARSGKRGGG 646

Human   607 ----------DQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPES 661
                      ..|..|.......|:    .|.|    .|||.|::|.||.:       :|||.:.
  Fly   647 SGNGAGGEEDSYQTPPLSADDTKPA----SRVG----FFSKLTARFGRRVI-------HLNEKDV 696

Human   662 KDRVETL 668
            .::.:.|
  Fly   697 TEQRKNL 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARK2	NP_001034558.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46		13/49 (27%)
		STKc_MARK	52..304	CDD:270974	184/251 (73%)
		UBA_MARK2	322..363	CDD:270589	14/40 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	373..632		70/301 (23%)
		MARK2_C	689..787	CDD:213386
KP78a	NP_650066.1	Protein Kinases, catalytic domain	98..349	CDD:473864	184/250 (74%)
		UBA_MARK_Par1	370..408	CDD:270522	13/37 (35%)