Protein Alignment MARK2 and KP78b

DIOPT Version :10

• Sequence 1: NP_001034558.2
• Gene: MARK2 / 2011
• HGNCID: 3332
• Length: 788
• Species: Homo sapiens
• Sequence 2: NP_650065.1
• Gene: KP78b / 41361
• FlyBaseID: FBgn0026063
• Length: 604
• Species: Drosophila melanogaster
• Alignment Length: 666
• Identity: 270/666 - (40%)
• Similarity: 377/666 - (56%)
• Gaps: 97/666 - (14%)

Human     1 MSSARTPLPTLNERDTEQPT-LGHLDSKPSSKSNMIRGRNSATSADEQPHI---------GNYRL 55
            |::|.|...|..|.|....| :....:.||:.:..:.|...::.....|..         |.|::
  Fly     1 MTAANTNKTTDKENDPGPNTSISTTATPPSAAAQNVGGCFGSSGGRSSPKFQSYVNGNGYGVYKI 65

Human    56 LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 120
            :||:|||||||||||.|:.||:|||:|:||||.||:.:.|||:|||.|||.|||||||:|.:|||
  Fly    66 IKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTIARQKLYREVNIMKKLNHPNIVRLLQVIE 130

Human   121 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDA 185
            :|:||||||||.||||:|:|||.:|||:|::||..|||:|||::|||.|.||||||||||||||.
  Fly   131 SERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKAENLLLDQ 195

Human   186 DMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 250
            .|.:||||||||..|.....|:||||||||||||||:||||.|||||.|||||:|||||||||||
  Fly   196 QMKLKIADFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLVSGSLPF 260

Human   251 DGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHED-DELK 314
            ||.||||||:||||||||:|:|:|.:||:|::|||:|||::|.:|..:|.|||:|:|:|. :.|:
  Fly   261 DGTNLKELRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWINMGYEQGNGLR 325

Human   315 PYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRP 379
            |:.|...|..|..|..|:.:||:...:::.||..|:::::..||:||.           ..|||.
  Fly   326 PFQEKPMDLHDVNRLSLLSNMGHKPRDVEQSLKNQKFDDIYCTYMLLD-----------VAKPRS 379

Human   380 SADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSN---SYSKKTQSNNAENK-RPEED 440
            :|....|.:     ..:.:.:|.|...|.....|.|.:..|.   :..|.|.:..|... ||...
  Fly   380 TACSEKSGS-----SFRETPTAMPGSSRIPVPIAAPNVTISQVTFALDKSTPNRPAATSIRPMAP 439

Human   441 RESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDS 505
            |.:.         ..:|||      .||.|  ...:..|.:::.|....|.:|:.|::
  Fly   440 RLAN---------ALTPLP------LTPPP--KKYICCSASKAANPRRSEPSSIPQSA------- 480

Human   506 LTMP--GSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQ--RVP 566
              ||  |..:.....:..:||.|.....:.::::.|..::   |.|:|      ||.|.:  |.|
  Fly   481 --MPKKGVGSPVDVKTTLLSAQRKLAVNQKLTSASHQIRS---PITQS------PSQASECTRTP 534

Human   567 VASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGAS 631
               |:...:..|...|.:.                |:.|......|       ||..:..|....
  Fly   535 ---PTHFEMLDSTSTPLKV----------------LKLVASNSQTP-------PSTENTNRPTRV 573

Human   632 GSIFSKFTSKFVRRNL 647
            | .|||.:::||||:|
  Fly   574 G-FFSKLSARFVRRSL 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARK2	NP_001034558.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46		10/45 (22%)
		STKc_MARK	52..304	CDD:270974	177/251 (71%)
		UBA_MARK2	322..363	CDD:270589	13/40 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	373..632		52/266 (20%)
		MARK2_C	689..787	CDD:213386
KP78b	NP_650065.1	Protein Kinases, catalytic domain	63..314	CDD:473864	177/250 (71%)
		UBA_MARK_Par1	335..373	CDD:270522	11/37 (30%)