Protein Alignment MARK2 and Nuak

DIOPT Version :10

• Sequence 1: NP_001034558.2
• Gene: MARK2 / 2011
• HGNCID: 3332
• Length: 788
• Species: Homo sapiens
• Sequence 2: NP_001369005.1
• Gene: Nuak / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Alignment Length: 783
• Identity: 221/783 - (28%)
• Similarity: 352/783 - (44%)
• Gaps: 139/783 - (17%)

Human    15 DTEQPTLGHLDSKPSSK-SNMIRGRNSATSADEQPHIGNYR----LLKTIGKGNFAKVKLARHIL 74
            |....:|.|....|..: .|::.|..:..:.....|....|    ::|.:|:|.:.||:|..:..
  Fly    27 DATGNSLAHPSGIPQDQIDNIMSGIANTGNVKMNNHRKKLRQRFDIIKKLGQGTYGKVQLGINKE 91

Human    75 TGKEVAVKIIDKTQLNS-SSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVF 138
            ||:|||:|.|.|.::.: :.|.::.|||:||..::||||:.::||.|..:.:.||||:|:|||::
  Fly    92 TGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFENREKMVLVMEFAAGGELY 156

Human   139 DYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFG 203
            |||.....:.|:|||..|||:.:||.|||:..|.|||||.||:|||...|.||||||.||.|...
  Fly   157 DYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDEKGNAKIADFGLSNVFDDQ 221

Human   204 NKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY- 267
            ..|.||||||.||:||:.:|..|.|||||.|||||:|||||.||:||||.|.|.|.:::.:|.|
  Fly   222 RLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPFDGSNFKRLVKQISQGDYY 286

Human   268 --RIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELK--PYVEPLPDYKDPRR 328
              |.|...||    |::..|.:.|.||.::|||....|:|   |:|.:.  ...|.|.: :.|.|
  Fly   287 EPRKPSRAST----LIRDMLTVCPRKRASIEQICSHWWVN---ENDNVSCLDLAEDLAN-QTPVR 343

Human   329 TELMVSMGYTREEI-QDSLV-----GQRYNEVMATYLL-----------LGYKSSELE------- 369
            .::::|:  |...| .|.||     |....:..|...:           :|..::|.|
  Fly   344 LDVLLSL--TPATITADQLVVPSAEGAAAAKAAANERVPRSHSVGSIRDMGPPNTEAERRILDMV 406

Human   370 --GDTITLKPRPSADLTNSSAP-SPSHKVQRSVSANPKQRRFSDQAAGPAI-----PTSNSYSKK 426
              |....|.|.|:..:|.:.:| ....|:|.:||        ::.|||...     |.::|:...
  Fly   407 AAGGEAALMPSPTRTITPAQSPVQTKRKLQPTVS--------TENAAGTTAKKKEKPANSSFVIS 463

Human   427 TQSNNAENKRPE--EDRESGRKASSTAKVPAS-PLPGLERK---------------KTTPTPS-- 471
            ..........|.  |.:.:..:|.:.|.:|.. |:|...:|               .|||.|:
  Fly   464 KDGAPLTEAPPTIIEPQATLMEAETIANIPEEVPVPSYSQKDMQAVGDICDLLMGTATTPAPAPP 528

Human   472 TNSVLSTSTNRSRNSPLLERASLGQAS------IQNGKDSLTMPGSRASTASASAAVSAARP--- 527
            ..:.::....|.:...::|......|:      :...|.:..:.....|.:.|:|.|||..|
  Fly   529 APTPVARQPTRGKLDAVVETPEEKDATKVIKKFVNKHKTADLVNAINESASKAAAPVSAVAPPPF 593

Human   528 -----RQHQKSMSASVHPNKASGLPPTESNCEVPRPSTA-----PQRVPVASPSAHNI------- 575
                 .|.:.:::......:.|.:..|....:.|.|..|     |:::.:...|..:.
  Fly   594 VRKCSLQDESTLNKFNAERRKSRILETAEKFQPPPPVAAAPPEKPKKLSIPGVSVGSFKKEFEKK 658

Human   576 -----SSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIF 635
                 ::.|..|........|::     |....|..:..:.|    |.||. .:|...|:.
  Fly   659 ATNPPAAEGPTPGELRAQEQVAA-----AAAAAQEAETLSTP----PPSPV-VAQSLEGSD---- 709

Human   636 SKFTSKFVRRNLSFRFARRNLN---------EPESKDRVETLRPHVVGSGGNDKEKEEFREAKPR 691
                ||....::|...|||::.         :.||...|:.|.......|.::...::.||.|.:
  Fly   710 ----SKNSVASISLDEARRSMENSIALLLQAQNESSKEVDQLCAQTETIGVSEPATQQERERKLK 770

Human   692 SLR 694
            :.|
  Fly   771 NAR 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARK2	NP_001034558.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46		6/31 (19%)
		STKc_MARK	52..304	CDD:270974	123/259 (47%)
		UBA_MARK2	322..363	CDD:270589	10/57 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	373..632		56/315 (18%)
		MARK2_C	689..787	CDD:213386	2/6 (33%)
Nuak	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	122/256 (48%)