Protein Alignment MARK2 and Sik2

DIOPT Version :10

• Sequence 1: NP_001034558.2
• Gene: MARK2 / 2011
• HGNCID: 3332
• Length: 788
• Species: Homo sapiens
• Sequence 2: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Alignment Length: 779
• Identity: 282/779 - (36%)
• Similarity: 399/779 - (51%)
• Gaps: 141/779 - (18%)

Human    28 PSSKSNMIRGRNSATSAD-----EQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKT 87
            ||..|:.: |....:..|     |...:|.|.:.:||||||||.||||||.:|..|||:|||||:
  Fly   112 PSPTSSAV-GAGGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKS 175

Human    88 QLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEA 152
            ||:.::|||::|||.|||.|.||:|:||::|:||:..:|:|.||||.||:|||:..:|||.|..|
  Fly   176 QLDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAA 240

Human   153 RAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAA 217
            |.||.||:|||:|||:|.||||||||||||||.:||||||||||||.|..|..|.|:||||||||
  Fly   241 RFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAA 305

Human   218 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK 282
            ||:|:||:|.|||:|:|||||:||.||.|:|||||..|:.||:|||.|::||||:||::||:|::
  Fly   306 PEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIR 370

Human   283 KFLILNPSKRGTLEQIMKDRWM-------------NVGHEDDELKPYVEPLPDYKDPRRTELMVS 334
            :.|:|.|::|.|::||.:.|||             |:|   .|.:..|||..|.     ..:|..
  Fly   371 RMLVLEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNLG---AERQTSVEPSEDI-----LRIMAE 427

Human   335 -MGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRS 398
             :|...::.:.||....|:.|.|.||||        .|.::.|...|..| .:||.:.|....|.
  Fly   428 YVGIGSDKTRASLKKNTYDHVAAIYLLL--------QDRVSHKKEQSNGL-GASALASSTSASRM 483

Human   399 VSAN-----PKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPL 458
            :.::     |.|::...|:  ..|.||:..:|..........:.....|....|.:|..|| .|.
  Fly   484 IYSSRNDHQPTQQQSQQQS--KTISTSSILAKDQCHKRLSRHQTVLMSERNAHAGATPTVP-DPG 545

Human   459 PGLERK---KTTPTPST-NSVLSTSTNRS-------------RNSPLLERASLGQASIQNGKDSL 506
            ||...|   ...|.|.| :|.|:...|..             |.:||...||
  Fly   546 PGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDASGIPLPMRYTPLPTAAS------------- 597

Human   507 TMPGSRASTAS--ASAAVSAARPRQHQK-SMSASVHPNKASGLPPTESN--C-EVPRPSTAP--- 562
            ..|.:.:||:|  ...::|::.||.|:. ::|.|:..|      |:.:|  | |:......|
  Fly   598 PAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNN------PSLANLRCREMMEAGGGPVGA 656

Human   563 QRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHA-GQLRQVRDQQNL-----PYGVTP-ASP 620
            ..||:||...|...|.......|...|.:..:||..| |:....:.:.::     |...|| :|.
  Fly   657 VGVPLASKQLHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDPPKAESSVGGVPPPASTTPTSST 721

Human   621 SGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNE-------PESKDRVETL---------- 668
            :|...|.....|.|..| |.|.:..:.||. ::.||.:       .|:....:||
  Fly   722 AGPESGSAPCPGEINGK-TIKTMSSSSSFD-SKANLGQSFRYKMSAEASKLFQTLQESPLPVEQR 784

Human   669 ---RPHV---VGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSE 726
               |.||   .||||:                   |.:.|:..:.|...|..:|||...|..::
  Fly   785 TKRRVHVGSTNGSGGD-------------------SGQETNDAKSNGDSRSEKKVLAQGSSSTD 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARK2	NP_001034558.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46		5/22 (23%)
		STKc_MARK	52..304	CDD:270974	159/251 (63%)
		UBA_MARK2	322..363	CDD:270589	12/41 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	373..632		68/296 (23%)
		MARK2_C	689..787	CDD:213386	8/38 (21%)
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	159/251 (63%)
		UBA_SIK	418..458	CDD:270523	12/52 (23%)