Protein Alignment MARK2 and par-1

DIOPT Version :10

• Sequence 1: NP_001034558.2
• Gene: MARK2 / 2011
• HGNCID: 3332
• Length: 788
• Species: Homo sapiens
• Sequence 2: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Alignment Length: 824
• Identity: 422/824 - (51%)
• Similarity: 532/824 - (64%)
• Gaps: 132/824 - (16%)

Human     9 PTLNERDTEQPTLGHLDSKPSS---KSNMIRG------RNSAT---SADEQPHIGNYRLLKTIGK 61
            ||:|:.     .|....:.||:   :::..:|      |:||.   .|.|: |||.|:|:|||||
  Fly   203 PTVNKN-----VLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEE-HIGKYKLIKTIGK 261

Human    62 GNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLY 126
            |||||||||:|:.||||||:|||||||||..|||||||||||||:|:||||||||:|||||||||
  Fly   262 GNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLY 326

Human   127 LVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKI 191
            |:||||||||||||||.||||||||||.|||||||||||||||.|:||||||||||||:::||||
  Fly   327 LIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKI 391

Human   192 ADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLK 256
            ||||||||||.|:||||||||||||||||||||||||||||||||||||||||||||||||..|:
  Fly   392 ADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLR 456

Human   257 ELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLP 321
            |||||||||||||||||||||||||:|||:|||:||.:||.||.|:|||:|.|:||||||:||..
  Fly   457 ELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKA 521

Human   322 DYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELE------GDTITLK---- 376
            |..||:|.|.:|:|||.|.||:.||...||::|.|||||||.||::.|      |.:::|:
  Fly   522 DLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISG 586

Human   377 PRPSADLTNSSAPSPSHK-VQRSVSA-NPKQRRFSDQAAGP---------------AIPTSNSY- 423
            ....|:..::|..||:|: |.||:|| :.|..|.:....||               |:..||:|
  Fly   587 NDAGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGPTNAAATVAAATGAVGAVNPSNNYN 651

Human   424 ---SKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRN 485
               |...:::...|.:.:...:|.....:||::.|        :...|..:|..:|:|: :.:.|
  Fly   652 AAGSAADRASVGSNFKRQNTIDSATIKENTARLAA--------QNQRPASATQKMLTTA-DTTLN 707

Human   486 SPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTE 550
            ||...|.:. :....||  :.|:.|:           |...||:     |.:::...:|    ||
  Fly   708 SPAKPRTAT-KYDPTNG--NRTVSGT-----------SGIIPRR-----STTLYEKTSS----TE 749

Human   551 SNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPY-G 614
            ....:|..:....|:.:||.    :.||      .:|||.|.||||||:||.| .|:...|.| |
  Fly   750 KTNVIPAETNLFDRLRMASA----VKSS------RHFPRNVPSRSTFHSGQTR-ARNNTALEYSG 803

Human   615 VTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGND 679
            .:.||......||.    |.|||.:|:|.:|             |...|..
  Fly   804 TSGASGDSSHPGRM----SFFSKLSSRFSKR-------------PTIADEA-------------- 837

Human   680 KEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHED 744
                    ||||.|||||||||||.:.|:::|::||:|||.|:|..|..|:::|.|:||.|..:.
  Fly   838 --------AKPRVLRFTWSMKTTSPLMPDQIMQKIREVLDQNNCDYEQRERFVLWCVHGDPNTDS 894

Human   745 FVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 788
            .||||:||||||||||||||||||||||:.||||||:||.:|||
  Fly   895 LVQWEIEVCKLPRLSLNGVRFKRISGTSIGFKNIASRIAFDLKL 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARK2	NP_001034558.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46		11/48 (23%)
		STKc_MARK	52..304	CDD:270974	218/251 (87%)
		UBA_MARK2	322..363	CDD:270589	23/40 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	373..632		71/284 (25%)
		MARK2_C	689..787	CDD:213386	64/97 (66%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	218/251 (87%)
		UBA_MARK_Par1	525..563	CDD:270522	22/37 (59%)
		MARK1-3_C	839..936	CDD:213381	64/96 (67%)