DRSC/TRiP Functional Genomics Resources

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Protein Alignment ELK1 and aop

DIOPT Version :10

Sequence 1:NP_005220.2 Gene:ELK1 / 2002 HGNCID:3321 Length:428 Species:Homo sapiens
Sequence 2:NP_523455.2 Gene:aop / 33392 FlyBaseID:FBgn0000097 Length:732 Species:Drosophila melanogaster


Alignment Length:367 Identity:111/367 - (30%)
Similarity:153/367 - (41%) Gaps:86/367 - (23%)


- Green bases have known domain annotations that are detailed below.


Human     7 LWQFLLQLL--REQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYD 69
            ||.||.|||  |.|....:|:|..||.|.||:||...:|:|||::||..:|||||:||||||||.
  Fly   398 LWDFLQQLLNDRNQKYSDLIAWKCRDTGVFKIVDPAGLAKLWGIQKNHLSMNYDKMSRALRYYYR 462

Human    70 KNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSTMPNVAPAAI--HAAPGDTVSGKPG 132
            .||:|||.|::..|:|:..|      ||             :.|:...::  .:.|.:...|.|.
  Fly   463 VNILRKVQGERHCYQFLRNP------TE-------------LKNIKNISLLRQSTPANGNGGSPS 508

Human   133 TPKGAGMAGPGGLARSSRNEYMRSGLYSTFTIQSLQPQPP-----PHPRPAVVLPSAAPAGAAAP 192
            .|:|:..| ||..|..:.|...:|      ..|...||.|     |...|||...:||.|.|..|
  Fly   509 MPQGSSQA-PGSPAGQNWNPQQQS------QQQQQSPQRPASRNGPMSLPAVAAVAAAAAAAYGP 566

Human   193 PSGSRSTSPSPLEAC------LEAEEAGLPLQVILTPPEAPNLKSEELNVEPGLGRALPPEVKVE 251
            |    .|||..:.|.      |.|..||       .||.:|.|.:......|...:..|  :|:|
  Fly   567 P----PTSPLFMHAINGAFHYLSAAAAG-------PPPNSPALNTPSAVGGPDKFQFHP--LKLE 618

Human   252 -GPKEELEVAGE-----------RGFVPETTKAEPEVPPQEGVPA------RLPAVVMDTAGQAG 298
             |.....|.|||           :..........|.:...:|:..      ....|....|||:.
  Fly   619 NGSGSGSESAGEDLKPTDLSVSSKSTATSNEDCYPLIRNADGLTTIKLIRYNEHQVAASPAGQSP 683

Human   299 GH---------AASSPE-ISQPQKGRKPRDLELPLSPSLLGG 330
            .|         |:|||. :.|..:..:|    :|:.....||
  Fly   684 KHDDQQAGASNASSSPRPMDQASEQAQP----VPMESDCNGG 721

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ELK1NP_005220.2 ETS 4..89 CDD:197710 45/83 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 121..149 9/27 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 165..205 17/44 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 228..358 26/131 (20%)
Sufficient for interaction with MAD2L2. /evidence=ECO:0000269|PubMed:17296730 349..399
aopNP_523455.2 SAM_PNT-Tel_Yan 49..116 CDD:176085
ETS 395..482 CDD:197710 45/83 (54%)
Blue background indicates that the domain is not in the aligned region.

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