Protein Alignment CC2D1B and l(2)gd1

DIOPT Version :10

• Sequence 1: NP_115825.1
• Gene: CC2D1B / 200014
• HGNCID: 29386
• Length: 858
• Species: Homo sapiens
• Sequence 2: NP_001245976.1
• Gene: l(2)gd1 / 34543
• FlyBaseID: FBgn0261983
• Length: 834
• Species: Drosophila melanogaster
• Alignment Length: 931
• Identity: 308/931 - (33%)
• Similarity: 483/931 - (51%)
• Gaps: 185/931 - (19%)

Human     8 RKGPQARGQGVAAAKQMGLFMEFG----PEDMLLGMDEAED---DEDLEAELLALTGEAQTTGKK 65
            ||.|:.     |..:|..| .:||    |:|........||   |.||||||.|:||   ..|.|
  Fly     4 RKKPEP-----AKRRQHDL-SQFGLTEIPDDFDPSAGYGEDDGGDSDLEAELAAITG---GEGAK 59

Human    66 PAPKGQAP-LPMAHIEKLAADCMRDVEEEEEEEGLEEDAELLTELQEVLGVD--EETEPLDGDEV 127
            |.||.:|. ||.:.::|:.||.:|||.::::::.||.|.:||.||..:.|::  ||.||     |
  Fly    60 PKPKPKAKLLPASDLDKMIADSLRDVSDDDDDDNLESDPDLLGELSGIGGLEEAEEEEP-----V 119

Human   128 ADPGGSEEENGLEDTEPPVQTAVLTASAPAAQAGASQGLHALLEERIHNYREAAASAKEAGEAAK 192
            |.|..:.||        ||||.:.|.:....         :::::|:..|::|.|:||.||::.|
  Fly   120 AQPPAASEE--------PVQTFLPTTTVDTL---------SIIKQRLEMYKQAEANAKTAGDSGK 167

Human   193 ARRCERGLKTLESQLASVRRGRKINEDEIPPPVAL----GKRPLAPQE--PANRSPETDPPAPPA 251
            |||..||||||:........|:.||.|:|||.|::    |:.|..|.|  ||..:|.:.||.|..
  Fly   168 ARRFGRGLKTLKDLHRQAAAGKSINVDDIPPEVSVKPIGGQAPPVPAEESPAPSTPASPPPVPSR 232

Human   252 LESDNPSQPETSLPGISAQPVSDLDP--DPRALLS---SRQREYKVAALSAKRAGELDRARELMR 311
            ...|.|:      ||...:|.:.:.|  .|..|::   |||.:||.|||.:||:|::..|.:.::
  Fly   233 AAPDPPT------PGTPVEPTTSVAPTSPPNPLVTQMRSRQTDYKAAALQSKRSGDISTALQFLK 291

Human   312 IGKRFGAVLEALEKGQPVDLSAMPPAP----EDLKPQQASQAPTAPSVIPPAVERVQPVMAPDVP 372
            :.|:|..|::..|.||.||||.|||.|    |.||..|...|..|.:         :|..||:
  Fly   292 VVKQFDVVIKMCEDGQEVDLSDMPPPPAEFLEFLKKMQEEAAAEAVA---------EPTAAPE-- 345

Human   373 ATPVAP----TESQTVLDALQQRLNKYREAGIQARSGGDERKARMHERIAKQYQDAIRAHRAGRK 433
            .|||||    ..:..:|:||||||.||:.....|::..:..|||...||.|||:|||:.::||:.
  Fly   346 PTPVAPAPVLAAATNMLEALQQRLEKYQSVEAAAKAENNSGKARRFGRIVKQYEDAIKLYKAGKP 410

Human   434 VNFAELPVPPGFPPIPGLESTMGVEEDAVAATLAAAEKLASAEDSAPADKDEDEPPGHLQGEPPA 498
            |.:.||||||||.|:|..::
  Fly   411 VPYDELPVPPGFGPLPTADA--------------------------------------------- 430

Human   499 QAPVAKKPARPTVPSSQRLPEPRASSS----------------KESPSPS--------------- 532
             ||||..|:.||.|:|   |.|.||:|                :::|||.
  Fly   431 -APVAPTPSLPTSPTS---PPPTASTSAGGTPSSSSATTPTAPRKAPSPPKPKELTTRTSGNQQK 491

Human   533 ---VREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARSGRPVDLSKVPSP 594
               ..:|:.||..|:.:::.||::||::.:::|||.||::.|..::.:..|.||.|||||.:|.|
  Fly   492 NNIAEQQMKLLLERQKEFKLAAIEAKKAGEIDQAKEYLKIFKGFDSLLNAASSGLPVDLSTLPVP 556

Human   595 LTDE---EGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMHQGNVAETTRFEKL 656
            .:..   |..|.::..|:...:....|:..::::.|.:|...|..........|:||...|||.|
  Fly   557 PSQRDNLEASFAIVSAEECDPTDDICEIGVRMEEQLAKQLMMCKNTRDHHKAMGDVAGMNRFENL 621

Human   657 AQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHLIIVRGMNLPAPPGVTPDD 721
            |...:|.|::::.::.:....|..|:|.::|..|...::|..:|:.:::|||::...   ..|.|
  Fly   622 ALTVQKDLDLVRYSKRKNEPLPKFHYEKRSFNIVHCNTDLTDSELEIVVVRGISYNV---ANPKD 683

Human   722 LDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINRNHRGFKRVIQSKGIKFEIFHKG 786
            :|.:||.||...| |::.|:||.|:::|:||::|:.||::|.|.:|.|:|:.:..|:||||:.:|
  Fly   684 VDTYVRVEFPLLN-DESFKTKTNVIRDTSSPDYDERFKVDIQRTNRQFQRIFKRHGVKFEIYSRG 747

Human   787 ------------------SFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPTGGKLEVKVR 833
                              .|.|||.|:||.::||:.||.:|||.:..:::||||..|||||||:|
  Fly   748 CSIDCCGLSRKLPLCCFRGFLRSDTLIGTVNVKLQPLETKCEIHDTYDLMDGRKQVGGKLEVKIR 812

Human   834 LREPLSGQDVQMVTENWLVLE 854
            :|.|:..:.::.:||.||||:
  Fly   813 VRNPILTKQMEHITEKWLVLD 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CC2D1B	NP_115825.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..164		15/53 (28%)
		DM14	168..225	CDD:128928	25/56 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	180..199		10/18 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	204..284		26/87 (30%)
		PHA03247	<220..520	CDD:223021	106/318 (33%)
		DM14	281..338	CDD:128928	26/59 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	329..352		13/26 (50%)
		DM14	385..439	CDD:128928	24/53 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	470..533		17/96 (18%)
		DM14	537..594	CDD:128928	22/56 (39%)
		C2_Freud-1	696..853	CDD:176072	67/174 (39%)
l(2)gd1	NP_001245976.1	DM14	142..200	CDD:128928	25/66 (38%)
		DM14	260..318	CDD:128928	25/57 (44%)
		DM14	362..420	CDD:128928	28/57 (49%)
		DM14	499..557	CDD:128928	22/57 (39%)
		C2_Freud-1	661..832	CDD:176072	67/174 (39%)