DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A9 and CG32669

DIOPT Version :9

Sequence 1:	XP_011539226.1	Gene:	SLC5A9 / 200010	HGNCID:	22146	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_727460.1	Gene:	CG32669 / 326229	FlyBaseID:	FBgn0052669	Length:	604	Species:	Drosophila melanogaster

Alignment Length:	702	Identity:	146/702 - (20%)
Similarity:	255/702 - (36%)	Gaps:	182/702 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    33 LHAYDISVVVIYFVFVIAVGI-WSSIRASRGTIGGYFLAGRSMSWWPIGASLMSSNVGSGLFIGL 96
            |.|:|.:::.:..:..:|:|| :..:...:.|...|.||.|||:..|:..|||:|.:.:...:|:
  Fly     4 LGAWDYTILAVVLIISVAIGIYYRFVGGKQSTTTEYLLADRSMNVAPVAFSLMASFMSAVTILGV 68

Human    97 AGTGAAGGLAVGGFEWNMRKSRSGGDRGIHPRSHGRTGVRSQVSYFSVRGPPTAQHCLWVGSRPS 161
            :                           :....:|...|...:||  |...|.|
  Fly    69 S---------------------------MENYQYGTMFVVINLSY--VLSTPVA----------- 93

Human   162 VYIQDLDTFFFSPLSQATWLLLALGWVFVPVYIAAGVVTMPQYLKKRFG-GQRIQVYMSV-LSLI 224
                                    .::.:||:......::.:||:.||| ..|:...:|. |.::
  Fly    94 ------------------------AYLIIPVFYRLKTASVYEYLELRFGYATRLAASLSFSLQMV 134

Human   225 LYIFTKISTDIFSGALFIQMALGWNLYLSTGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGAL 289
            ||    :...:::.||.::...|.:...|..|:.||...|...||:.||:.||..|:::|.....
  Fly   135 LY----MGIVVYAPALALEAVTGLSQVFSIVIVGVVCTFYATLGGMKAVLITDIYQSLLMFAAVF 195

Human   290 VLMFLGFQDVGWYPGLEQRYRQAIPNVTVPNTTCHLPRPDAFHILRDPVI--------------- 339
            .::...:...|   .||..:|.|..|..: |.|.....|...|.....::
  Fly   196 SVIICAWVKAG---SLEVIWRVAQENGRI-NLTNFSVDPTERHTWFTQILGGCATYLAIYGVNQT 256

Human   340 -VQRSLSAKSLSHAKGGSVLGGYLKILPMFFI--VMPGMISRALFPDEVGCVDPDVCQRICGARV 401
             |||.::.||||.|:  :.|...|.||.:..:  ...|:.....:.|         |..:...||
  Fly   257 QVQRLMAVKSLSAAR--AALWWCLPILCLLSLSTCFSGLCIYWYYRD---------CDPLLEGRV 310

Human   402 GCSNIAYPKLVMALMP--VGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRF-----RRKS 459
            ...:...|..|:..|.  .||.||.::.|..|.:|:::||.:|.:.:...|..:..     :|..
  Fly   311 NSRDQVMPLFVVDTMGEYTGLAGLFVSGIFCASLSTISSIISSLAAVTLEDYLKPLVSCCAKRTL 375

Human   460 TEQELMVVGRVFVVFLVVISILWIPIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTE 524
            |:::.:...::..:|...:.|..  ...:.:.|.|.....::...:..|:..||.|.::..:..|
  Fly   376 TDRQTLWYSKLLSLFFGALCIGM--AFMAGSIGGLLQAALSIFGIIGGPLLGLFTLGMYVTKANE 438

Human   525 PGAFWGLVFGLG----VGLLRMILEFSYPAP----------ACGEVDRR----------PAVLKD 565
            .||..||:..|.    :|       |..|.|          .| .|||.          .||.::
  Fly   439 KGAIGGLLISLAFCFWIG-------FGQPKPPLVSLDMSTAGC-PVDRSFARDIFLKTVIAVAEE 495

Human   566 FHYLY-FAILLCGLTAIVIVIVSLCTTPIPEEQLTRLTW------WTRN--------CPLSELEK 615
            .||.| :.|......|:..:|.....        ..|:|      |..|        |.|.:
  Fly   496 EHYFYLYRISYMWYAALGFLITFFGG--------WLLSWLFALLKWDNNRRIYQDADCTLIK--- 549

Human   616 EAHE-STPEISER-PAGECP---AGGGAAENSSLGQEQPEAPSR----SWGK 658
              |: ..|.|::| ...:.|   ..|.::|...:..|...||.|    .|.|
  Fly   550 --HDLFVPPIAKRLQRRQMPLLVVTGTSSEIGGITTESATAPPRLDEIEWEK 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A9	XP_011539226.1	SLC5-6-like_sbd	37..719	CDD:294310	144/698 (21%)
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	126/620 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6277
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840