DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ELF4 and Ets65A

DIOPT Version :9

Sequence 1:	NP_001120669.1	Gene:	ELF4 / 2000	HGNCID:	3319	Length:	663	Species:	Homo sapiens
Sequence 2:	NP_001303373.1	Gene:	Ets65A / 38700	FlyBaseID:	FBgn0005658	Length:	728	Species:	Drosophila melanogaster

Alignment Length:	591	Identity:	142/591 - (24%)
Similarity:	217/591 - (36%)	Gaps:	172/591 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    44 DLLHLYSGLELDDVHNGIITDGTLCMTQDQILEGSFLLTDDNEATSHTMSTAEVLLNMESPSDIL 108
            |.|...||.......:|:||.     :..|:..|          |...:|.|..|.::.:.|...
  Fly   147 DTLQPPSGCSPAVTQHGVITS-----SAGQVTSG----------TLDAVSAAPALPSLTASSSSH 196

Human   109 DEKQIFSTSEMLPDSDPAPAVTLPNYLFPASEPDALNRAGDTSDQEGHSLEEKASREE------S 167
            .|.::.:      |.......|..::   |:.|.:.:.|.|  .|:|.....|:|...      |
  Fly   197 VEHKVRA------DKSTLDCATTSSH---AAAPSSSSSASD--HQQGRISGSKSSNTSGTGGGAS 250

Human   168 AKKTGKSK--KRIRKTKGNRSTSPVT-----------DPSIPIR-------------KKSKDGKG 206
            |...|.|.  ...:.:.|:.|::...           ||...:|             :.:..|.|
  Fly   251 ASGGGGSALYSSYKSSWGSHSSTQSQGYSSNALGIKHDPHSQLRQPDPYQMFGPTSSRLASSGSG 315

Human   207 STIYLWEFLLALLQDRN--TCPKYIKWTQREKGIFKLVDSKAVSKLWGKQKNKPDMNYETMGRAL 269
            . |.||:|||.||.|.|  :|   |.| :...|.|||.|...|::.||::|:||:|||:.:.|||
  Fly   316 Q-IQLWQFLLELLSDSNNASC---ITW-EGTNGEFKLTDPDEVARRWGERKSKPNMNYDKLSRAL 375

Human   270 RYYYQRGILAKVEGQRLVYQFKEMPKDLVVIEDEDESSEATAAPPQASTASVASAS----TTRRT 330
            ||||.:.|:.||.|:|..|:|             |....|.|..|.||..:....|    |....
  Fly   376 RYYYDKNIMTKVHGKRYAYKF-------------DFQGLAAATQPAASDPTYKYQSDLFMTPYHH 427

Human   331 SSRVSSRSAP-QGKGSSS------------WEKP--------KIQHVGLQPSASLELGPSLDE-- 372
            |:::||..:| .|..|||            |..|        .:.||  .||   .:.|.|..
  Fly   428 SAKLSSFMSPHHGMTSSSASIFPSAASWGNWGSPATNLYQPHSMSHV--TPS---HVAPHLSSYP 487

Human   373 --EIPTTSTMLVSPAEGQVKLTKAVSASSVPSNIHL-GVAPVGSGSALTLQT-IPLT-------- 425
              . |::|.... .....:.....:...:..:.:.: ||...|.|....:.| :..|
  Fly   488 HYAXPSSSGGAFXYESNAIASASGIGGGTASTGVGIGGVGGAGGGGGSGVSTGVGSTSSSTTSSG 552

Human   426 ----------TVLT--------NGPPASTTAPTQLVLQSVPAASTFKDTFTLQASFPLNAS---- 468
                      ||::        ||...|::..:..|..::..|     |.||.|: |.:||
  Fly   553 AGGGGGGGGGTVMSGFGSNGNLNGSHVSSSGGSSSVSNNLNIA-----TATLTAT-PAHASAGFG 611

Human   469 -FQDSQVAAPGAPLIL--------SGLPQLLAGANRPTNPAPPTV------------TGAGPAGP 512
             .....||..|..:.:        |.|..|:.| ||..|.:.||:            .||||:.|
  Fly   612 TIGGLSVAGMGVGVGVGVGVGGGNSTLNSLVVG-NRLMNSSLPTLLKXCHLEKFGLTMGAGPSPP 675

Human   513 SSQPPG 518
            ::.|.|
  Fly   676 AATPAG 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ELF4	NP_001120669.1	Elf-1_N	2..104	CDD:315071	13/59 (22%)
		RUNX1-binding. /evidence=ECO:0000269\|PubMed:10207087	87..206		26/150 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..203		16/94 (17%)
		ETS	208..290	CDD:197710	40/83 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..353		18/75 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	493..518		11/36 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	582..605
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	635..663
Ets65A	NP_001303373.1	ETS	316..401	CDD:197710	42/102 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910