DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCA2 and CG42816

DIOPT Version :9

Sequence 1:	NP_997698.1	Gene:	ABCA2 / 20	HGNCID:	32	Length:	2466	Species:	Homo sapiens
Sequence 2:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster

Alignment Length:	1821	Identity:	443/1821 - (24%)
Similarity:	765/1821 - (42%)	Gaps:	479/1821 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   685 YFLY--GFVWIQDMMERAIIDTFVGH----------DVVEPGSYVQMFPYPCYTRDDFLFVIEHM 737
            |.||  ||:.:|    :|:....:.|          |:..|.  ::..|.|...:.|....::.:
  Fly     8 YPLYKTGFLAVQ----QALSQVHIKHKCKEFNKTQGDIKFPP--IKDLPSPPIFKSDNSSTLQDV 66

Human   738 MPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAIL 802
            ..:.:||...:.|....:.||.|||.:||..:..||:.:.:.||||:|..|:...|..:.:|...
  Fly    67 GIMIIVIIIFFVVVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSSIITLFW 131

Human   803 KYGQVLMHSHVVII----W---LF-LAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPY 859
            |.  ||.:|.:..:    |   || |.|.:..||.|.||:|.|.|.....|....:....:|:|:
  Fly   132 KL--VLPNSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLALIATYLPF 194

Human   860 MYVAIREEVAHDK---------ITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSP 915
            :       :.|.|         ::.|   :.|.:.....|:     .::|..|.|:||....::.
  Fly   195 L-------ILHSKGCSEGLNVFLSLF---LLSGLQVLVVGI-----CMWEDYGEGLQWGNLFETS 244

Human   916 VEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSW 980
            ..|...::...:.::::.:.:..:|..|:|.:.||.||:|:||:||..:
  Fly   245 WPGGTLSVGYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTR---------------- 293

Human   981 PWARTPRLSVMEEDQACAME-----SRRFEETRGM-----EEEPTHLPLVV--CVDK-------- 1025
                           .|:.|     ||.|....|:     :||...|.|:.  .|||
  Fly   294 ---------------CCSTESLLPYSRLFNRIFGIYSAAPDEERPDLQLIEPDPVDKIAGVQIRG 343

Human  1026 LTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1090
            |:|.:  .|...:..:|.:::|.|:...:|||||||||.:|:|.|...||||:|.|.|.|||.|.
  Fly   344 LSKTF--GKMEVVKNVSFDMFEGQITVLMGHNGAGKTTLISMLAGFISPTSGTALINGFDIRQER 406

Human  1091 DEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLS 1155
            .:.::.:|:|||.||||..|:...|:..:|||:.:...|::.|:...::.|.|..|:....:.||
  Fly   407 RQAQRCIGLCPQQNVLFKHLSSVSHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLS 471

Human  1156 GGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGD 1220
            ||.:|:||||.:..||.:.:|.|||:.|:||.|||.:|.|||:.|.|.||||:||.:|:.::|||
  Fly   472 GGTQRRLSVACSLCGGVKVLICDEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGD 536

Human  1221 RIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVS 1285
            |:.|||.|:|:|.||..|||........:|...|                      ..|...:::
  Fly   537 RVVIISDGQLRCIGSLPFLKKQVDASCLITCEAR----------------------KRCDLEKLT 579

Human  1286 QFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFL 1350
            ..|.:||.:....|....::.|.||  .:|...|..||:.||..::.|.:..|.|...:|||:|:
  Fly   580 SLISRHVGTIQPFSIKGRDVCYKLP--LSKSKYFSSLFRDLESQMNILGVRGFSLSSVSLEEIFM 642

Human  1351 KVSEEDQSLENSEADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQSQASLQSASSVGSARGD 1415
            ....||                                              |.|..|.|:.:.|
  Fly   643 SFGAED----------------------------------------------LNSRQSGGAEKRD 661

Human  1416 EGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLKVR----QFHGLLVK 1476
            :.              |...|.:|    ||:              ||   .||    |:..::.|
  Fly   662 DD--------------DRDDDEEN----EVQ--------------DG---NVRSCKKQWRAMMTK 691

Human  1477 RFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQPRGNFIPYANE 1541
            :. .|..::|..|..:||              .|.:..:..|:::...:|: .:|..|...|.
  Fly   692 KV-MALYDNKVYFLLLLL--------------TPIVYYITTLMMATKPHHS-GRPTFNISDYG-- 738

Human  1542 ERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNLSSGESRLLAARFFDSMC 1606
                              |..|        |.:|..|.:
  Fly   739 ------------------VDKF--------TILLSVPVS-------------------------- 751

Human  1607 LESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTAGPEMWTSAPSLPRLVREPVRC 1671
             :|:|:             ...:||.||
  Fly   752 -KSYTE-------------ERRADSIAS------------------------------------- 765

Human  1672 TCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNVSEYLLFTSDRFRLHRYGAITFGNVLKS 1736
                                   ::.|.:...:....:.:|:   .|::: .|.|......|  |
  Fly   766 -----------------------LIKGKLKLIVVSEQIKDYV---DDKWK-SREGRREINFV--S 801

Human  1737 IPASFGTRAPPMVRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAILRANL-PKSKGNPAAYGITV 1800
            :....|.|. .::..:..|...         |:.|..||.:.||:.:..: ||       ..|.|
  Fly   802 MAIDTGDRT-GLIGWVGPRHYV---------HAAPMILNLVYNALAQELIGPK-------ISIEV 849

Human  1801 TNHPMNKTSASLSLDYLLQGTDVVIAIFIIVAMSFVPASFVVF---LVAEKSTKAKHLQFVSGCN 1862
            |:.|.......   |:|:.... .|.|::|   .:|..:.::|   ::.|:.:..|.||.|||..
  Fly   850 TSVPFTLRKKE---DFLISNNG-DIPIYVI---GYVSIAMIIFSSAVIQERVSHMKMLQEVSGLE 907

Human  1863 PIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFW 1927
            .|.|||::..:||:.:.:     :::..:..|..|.     |..|.|.:|:...:..::: ..|.
  Fly   908 MITYWLSHLAFDMVVFFI-----LVLALLLPLYGYA-----PWYLLLCVLFFTGLAGLIF-IYFL 961

Human  1928 FEVPSSAY--VFLIVINLFIG-ITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLM 1989
            ..:.|:.:  |.:|::::.|| :...:...|..:|:    :..|..|:.:...:...||    .:
  Fly   962 ISMLSATFLAVSMILLSVIIGSLILMILGALALIFK----MVYVAIYVANMHPLIAGYN----CI 1018

Human  1990 EMAYN------EYINEYYAKIGQ---FDKM---------------KSPFEWDIVTRGLVAMAVEG 2030
            :..::      .||:|....:.:   .|:|               .:|..|.    .::.|....
  Fly  1019 QKCFHYMSLCGSYISEAQNPLSENLTSDEMYCINPLAFLEPRCVCVNPMTWP----DMLVMLGTA 1079

Human  2031 VVGFLLTIMCQYN---FLRRPQRMPVSTKPVEDDVDVASERQRVLRGDAD---NDMVKIENLTKV 2089
            ::.|||.:..:|.   :.|.....|.|:|...:|..|:.|.:::...|||   ...:.:..::|.
  Fly  1080 IILFLLIMFFEYGSCVWYRCKGCCPYSSKGSIEDPKVSREAEKIRAMDADQIGTRALVVNGVSKK 1144

Human  2090 YKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKELL 2154
            |...:    |||:.:...::|..|.||||.||||||:||||:.|:.|...|..:::|:|:..:..
  Fly  1145 YGCDQ----LAVNNISFALKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRN 1205

Human  2155 QVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADKPAGTYSG 2219
            :..:.||||||.|:.|:.||.|:.|:::..:.|...||..:..:...::....|:.||....|||
  Fly  1206 KAMKELGYCPQSDSFFEFLTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSG 1270

Human  2220 GNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCT 2284
            |.|||::.|:| .|..:.|.||||:.|:||.:||.:|.:|.::.:.|::|:||||:|:|..|||:
  Fly  1271 GTKRKINAAVA-CGANSLICLDEPSAGVDPASRRHVWTIINEVAQQGKAVLLTSHNMDEINALCS 1334

Human  2285 RLAIMVNGRLRCLGSIQHLKNRFGDGY------------MITVRTKSSQSVKDVVRFFNRNFPEA 2337
            :..|:|:|.:..:||:||:||:...|.            |:.:.||    ::|.:..   .:|.|
  Fly  1335 KSVILVDGSIYAMGSVQHVKNKIAKGMTLKLVVNVQPDNMVAMLTK----IEDDIYM---TYPNA 1392

Human  2338 MLKERHH--TKVQYQLKSEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFA----KKQS 2396
            .|||::.  .::.:|: |:..|.:::|..:|.......:||||:||.:|::.|...|    ||:|
  Fly  1393 ELKEKYEFSGRLTFQI-SKDTSWSEIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEERRKKKS 1456

Human  2397 D 2397
            :
  Fly  1457 N 1457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCA2	NP_997698.1	rim_protein	58..2398	CDD:130324	443/1821 (24%)
		ABC_subfamily_A	1021..1240	CDD:213230	97/228 (43%)
		ABC_subfamily_A	2081..2304	CDD:213230	84/222 (38%)
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	119/332 (36%)
		ABC_subfamily_A	339..556	CDD:213230	94/218 (43%)
		ABC2_membrane_3	<821..1018	CDD:289468	50/238 (21%)
		CcmA	1135..1450	CDD:224054	110/327 (34%)
		ABC_subfamily_A	1136..1354	CDD:213230	84/222 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	160	1.000	Domainoid score	I4044
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.730