DRSC/TRiP Functional Genomics Resources

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Protein Alignment ABCA2 and CG6052

DIOPT Version :10

Sequence 1:NP_997698.1 Gene:ABCA2 / 20 HGNCID:32 Length:2466 Species:Homo sapiens
Sequence 2:NP_649002.3 Gene:CG6052 / 39971 FlyBaseID:FBgn0036747 Length:1725 Species:Drosophila melanogaster


Alignment Length:1983 Identity:575/1983 - (28%)
Similarity:901/1983 - (45%) Gaps:465/1983 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   546 LQQYVAELRLHPEA----LNLSLDELPPALR--QDNFSL--PSGMALLQQLDTIDNAACG----W 598
            |.:.:.|:| :|..    |||.:..:|...|  .:|.||  |.........:.|::|..|    .
  Fly    62 LPEKMDEIR-YPTVSISDLNLYMRMVPLGNRILHENGSLNIPRNFLCYTPNNPINSAIVGATAIR 125

Human   599 IQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPHVHYKIRQNSSF- 662
            ::.:...:.|.......:..:.|:.....::||..|       ...|...|.:::|.:|..|.. 
  Fly   126 LRLLGTRAYDTALHMEQDMVLHNFLAGVQFEDNENV-------NTNDAGYPLNLNYSLRFPSELR 183

Human   663 --------TEKTNEIRRAYWRPG-----PNTGG--RFYFLYGFVWIQDMMERA-------IIDTF 705
                    |.:|:.:..:|...|     .|.||  ..|...||:.||..:..:       :.||.
  Fly   184 TMQGPIIDTWRTSRLFLSYDTSGSRNRLDNDGGVPVGYIREGFLPIQHALTMSWLALASGVTDTG 248

Human   706 VGHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMK 770
            :      |..::|.|||..||.|..|..:..::|..:::|::|..:...:::.:|||.:|||:||
  Fly   249 I------PAIHLQRFPYRAYTYDQLLSGLRQLLPFVILLSFIYPASTVTKYVTSEKELQLKEIMK 307

Human   771 TMGLNNAVHWVAWFITGFVQLSISVTALTAILK---YGQ--VLMHSHVVIIWLFLAVYAVATIMF 830
            .:|::|.:||||||:..::.|.:.|..:.:::.   |..  ||..|..|.:.|||..|.|.::..
  Fly   308 LIGVHNWLHWVAWFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCL 372

Human   831 CFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLM-STTAFGLGSK 894
            ||:::||:|||..|||...|.:||:|:||.:    ....:::::...|.:.||: |.:|.|.|..
  Fly   373 CFMLAVLFSKASTASAVAAIFWFLTYIPYSF----GYYYYERLSLMSKLLISLIFSNSALGFGIH 433

Human   895 YFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLM-VDAVVYGILTWYIEAVHPGMYGLPRPW 958
            ...::|..|.||.|..... ||..||...|..:.|.| ..::::..:..|:|.|.||.||:||.|
  Fly   434 VIVMWEGTGEGITWRNMFH-PVSTDDSLTLFYIIMTMSFGSIMFISICLYVEQVFPGEYGVPRRW 497

Human   959 YFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEEEPTHLPLVVCV 1023
            .|...|:||.              ...|.|:::...|.....|.:.:..|...|      :.:.:
  Fly   498 NFMCHKNYWR--------------QYVPSLNIVPSFQTILHGSAKAKSCRRARE------VGIQL 542

Human  1024 DKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRT 1088
            ..|.|.|  .|..|:..:||.::.|::...|||||||||||::::||:..||||:|.:.|:||||
  Fly   543 FNLQKNY--GKLKAVKGISLKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSGTAIVNGYDIRT 605

Human  1089 EMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSM-AQEEIRREMDKMIEDLELSNKRHSLVQ 1152
            .:.:.|::||:|||:|:||..::|.:|:.|:|:||.: ..:.:..|:.|.:..|:|.:|.:...:
  Fly   606 HLAKARESLGICPQNNILFKEMSVRDHIIFFSKLKGIRGTKAVENEVGKYMTMLKLQDKSYVAAK 670

Human  1153 TLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADL 1217
            .||||||||||:..|..|.::.::.|||::|:|...||::|||:...|.||||||:||:|||||:
  Fly   671 NLSGGMKRKLSLCCALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEADV 735

Human  1218 LGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSEL 1282
            |||||||:|.|||:|.|:..:||..:|.||.|..:.:                      |.|...
  Fly   736 LGDRIAILSEGKLQCQGTSFYLKKRFGTGYLLVCIMQ----------------------SGCDVG 778

Human  1283 QVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEE 1347
            .|:|.|||:|..........|||:|.||:|.:||  |..|.|.|:.....|.|..:||...|||:
  Fly   779 AVTQLIRKYVPPIKPERVLGTELTYRLPTEYSKK--FAELLQDLDEKCAQLQLVGYGLSGATLED 841

Human  1348 VFLKVSEEDQSLENSEADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQSQASLQSASSVGSA 1412
            ||:.|:.:               |.|..|||||                                
  Fly   842 VFMAVNTD---------------KRVQGGAEGP-------------------------------- 859

Human  1413 RGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLKVRQFHGLLVKR 1477
                                 |.| .::..:|:..::.:|..:..|:....|      ..|.:|:
  Fly   860 ---------------------PVD-GSIDFKELVFDSKTREKRRIRRCFMFW------QALFLKK 896

Human  1478 FHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIG----DLPPLVLSPSQYHNYTQPRGNFIPY 1538
            |:...||...|..|::||  ...:|:|:..|  ..|    :||.:.:|.:||.:           
  Fly   897 FYTTTRNYWLLGIQLVLP--IAVMALTILNS--RGGRIYYELPAMPISINQYSS----------- 946

Human  1539 ANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNLSSGESRLLAARFFD 1603
                                            |..||:.          |.:...|.|..|.   
  Fly   947 --------------------------------AYVVLED----------NTTDKTSSLADAY--- 966

Human  1604 SMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTAGPEMWTSAPSLPRLVREP 1668
            |..||.:.:                                                        
  Fly   967 SKHLEHYAR-------------------------------------------------------- 975

Human  1669 VRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTD--ITGHNVSEYLLFTSDRFRLHRYGAITF- 1730
             |||.                     :.|||:..:  |..|:|:.     |.|...|....:|. 
  Fly   976 -RCTL---------------------LRTGDLKFEDYILSHDVNH-----SRRIDFHFLAGLTVS 1013

Human  1731 -GNVLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPA 1794
             .|.:                         |:.|||..|:.|..||.|:||:    ..|..|..|
  Fly  1014 ENNFI-------------------------VWLNNKPLHTAPLTLNLLHNAL----AIKLLGQDA 1049

Human  1795 AYGITVTNHPMNKTSASLSLDYLLQG--TDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQF 1857
            :  ..|||.|:..:..:.:| .|.:|  ....|:|.:.:.|.|:.|.:.:.::.|:.|:||.|||
  Fly  1050 S--TYVTNEPLPYSDDTRTL-RLNKGQVLGAEISINLSLTMCFITAFYAIPIIRERETRAKLLQF 1111

Human  1858 VSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMY 1922
            :||.:...||.::.|||.|.:::.|...::.:..|....|.:|.:......:.|::|:....:.|
  Fly  1112 LSGVDVCAYWTSHIVWDYLVFVLSALSSILTIAAFKEIGYITPLDLSRYFYMLLIFGFPGIMLSY 1176

Human  1923 PASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLG-- 1985
            .||..|...::.:..:.:||..:| |.....|:...||..: ||.|...|...|.:.|:|:|.  
  Fly  1177 AASGCFSDAATGFTRISIINTLMG-TGLFLMFMTLNFEAFQ-LKDVAEKLAWYFRLSPHYSLASS 1239

Human  1986 -HGLMEMAYNEYINEYYAKIGQFDKMKS-------PFEWDI----------VTRGLVAMAVEGVV 2032
             |.: .:.||   ......||...|:..       |...||          |...:..|.:.|..
  Fly  1240 THSI-HIGYN---IRRGCSIGGIRKLPKQLRCRNVPICCDIPGYYGWRKPGVLVEITYMIMLGST 1300

Human  2033 GFLLTIM-----CQY------NFLRRPQRMPVSTKPVEDDVDVASERQRVLR-----GDADNDMV 2081
            .|||.:|     |..      |...:.:|:...|. :|:|..||  .|||:|     |..|..::
  Fly  1301 LFLLIVMHDAKVCNLIAEKLGNCFSKRKRVEGGTS-IENDSVVA--EQRVVREMINSGRKDVPLL 1362

Human  2082 KIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNG 2146
             :..::|.|:|:     |||..:...|...|||||||:||||||||||||.|||..|.|||:::|
  Fly  1363 -VYKISKRYRSK-----LAVKAISFHVPHAECFGLLGINGAGKTSTFKMLAGDEKITSGEAYIDG 1421

Human  2147 HSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALE-KLELTKYA 2210
            .::...  :|.:.:|||||.||||::||.||.|.:|..|||:. :.....:.|.|. .....|:.
  Fly  1422 TNISTH--KVYRKIGYCPQFDALFEDLTGRETLNIYCLLRGVQ-RRHVTPICWGLAISFGFAKHM 1483

Human  2211 DKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKT-GRSVVLTSH 2274
            ||....|||||:|||||||:::|.|:.::|||||:||||.|||.||. |:.||:| |:|:|||||
  Fly  1484 DKQTKHYSGGNRRKLSTAISVLGNPSVLYLDEPTSGMDPAARRQLWQ-IIGLIRTAGKSIVLTSH 1547

Human  2275 SMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTK--------------------- 2318
            ||:||||||:||||||:|..:||||:|.|||:|..|.::.|:.|                     
  Fly  1548 SMDECEALCSRLAIMVDGEFKCLGSVQSLKNQFSKGLILKVKVKHKKKTFQRVVEDSSSSNDKKS 1612

Human  2319 ----------------SSQS--VKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKM 2365
                            |||:  :..|.||.::..|:|.|||.::..:.|.:.... :|:::|..:
  Fly  1613 ISETDLKFLQMASVMESSQADRILKVNRFISKEIPDAELKEEYNGLITYYIPHSK-TLSKIFQLL 1676

Human  2366 EQVSGVLGIEDYSVSQTTLDNVFVNFAKKQSDN 2398
            |..|..|.||||.:.||.|:.:|::||.|:..:
  Fly  1677 ETNSHKLNIEDYLIMQTRLEEIFLDFASKRDSS 1709

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCA2NP_997698.1 rim_protein 58..2398 CDD:130324 575/1981 (29%)
CG6052NP_649002.3 rim_protein 21..>54 CDD:130324
rim_protein <149..1709 CDD:130324 557/1893 (29%)
Blue background indicates that the domain is not in the aligned region.

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