Protein Alignment ABCA2 and Eato

DIOPT Version :9

• Sequence 1: NP_997698.1
• Gene: ABCA2 / 20
• HGNCID: 32
• Length: 2466
• Species: Homo sapiens
• Sequence 2: NP_001036360.1
• Gene: Eato / 34783
• FlyBaseID: FBgn0028539
• Length: 1597
• Species: Drosophila melanogaster
• Alignment Length: 2062
• Identity: 497/2062 - (24%)
• Similarity: 811/2062 - (39%)
• Gaps: 618/2062 - (29%)

Human   474 QRNLGLLVHLMTSNPKILYAPAGSEVDRVILKANETFA----------FVGNVTHYAQVWLNISA 528
            ||||..|:.:.:....:|.|.....|..|:.:.|:..|          |.||...|. .:..||.
  Fly    21 QRNLLPLLLICSGFAGVLTAYLHWSVKPVLHQINQFEAKNEMVLRELYFPGNELDYI-YYSPISP 84

Human   529 EIRSFLEQGRLQQHLRWLQQYVAELRLHPEALNLSLDELPPALRQDNFSLPSGMALLQQLDTIDN 593
            .:...:                       :.|.:.|..:|..||.:|.|....:.:.||.    .
  Fly    85 NVEDIM-----------------------DLLRVDLGIIPERLRPNNNSFEMQLEMEQQC----R 122

Human   594 AACGWIQFMSKVSVDIFKGFPDEES--IVNYTL--NQAYQDNVTVFASVIFQTRKDGSLPPHVHY 654
            .:|        .::| |...|:..|  ...|:|  ||           :....||.......:::
  Fly   123 GSC--------FAID-FHRVPNRGSDRKFRYSLSSNQ-----------MRISPRKRFVNDEEIYH 167

Human   655 KIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYGFVWIQDMMER-------------AIIDTFV 706
            :|..:.                        |...||:.:|.::::             .::.:..
  Fly   168 QIDDDD------------------------YIRSGFLSLQHILDKQYMKYQELGKDFEVVVSSMP 208

Human   707 GHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKT 771
            ..:|:...|:                .:.:...||.::..|..::..:...|.||::.|||.:..
  Fly   209 NMEVISMDSH----------------RLTYFGTLCSILFNVVLLSSFVVPFVEEKQNGLKEFLNL 257

Human   772 MGLNNAVHWVAWFITGFV---QLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCFL 833
            :...:.::.:.:|:..||   .|.|.|..:..:.|....:..::|.:::|   :|.::|:.:.:|
  Fly   258 VTPMSFLNGLTFFLIRFVCYTLLMIFVLVVAYLYKALGSICFAYVAVLFL---LYILSTMSYAYL 319

Human   834 VSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLGSKYFAL 898
            :|:.:.....|. .||:...:  :||.:..:|..........|        ||..|
  Fly   320 ISICFHSVFYAK-IGGLAMLI--IPYAFSFVRSWATSLAFVCF--------STNTF--------- 364

Human   899 YEVAGVGIQWHTFSQS-------------PVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPG 950
              :.|:.| :.|||..             .::.:...:.....:|:..:.:|.:|..|:..|.||
  Fly   365 --LEGLDI-FQTFSNKRKNREFGAVDVFRVIKSNSSTMFSVYVVLVFQSFLYAMLYNYLGCVFPG 426

Human   951 MYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEEEPT 1015
            ..||.||.:|.|....::...|.|       :..|||                          .|
  Fly   427 PGGLKRPMFFFLDPKTYMKRQRNE-------YTTTPR--------------------------GT 458

Human  1016 HLPLVVCVDKLTKVYKDDKK--LALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGS 1078
            |   .:.:.:|.|.::..|:  |..:.|::.:...::...||||||||||.|:::.||.|..||.
  Fly   459 H---AIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKDSGK 520

Human  1079 ATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLEL 1143
            ..:..   ..::...|..:|.||||:|....:|..:||.|:::|:...:.:.|...|:.::.|.|
  Fly   521 IIVCS---ERDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDWADEKLKKLGL 582

Human  1144 SNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLS 1208
            |:||:...:.|||||||:||:.||..|.::.:|||||::|:|..:||.:||::|..:..:.:|::
  Fly   583 SDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKAVLVT 647

Human  1209 THHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGR 1273
            ||:|:||::|||.|.|:::|||:..||||.||...|.||||.|....
  Fly   648 THYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKLEIND------------------ 694

Human  1274 APLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSF 1338
               .:..|:::.:.|...|.:..:::..:..:...||  .|.|..|.::...||.....|.:.:.
  Fly   695 ---FTSREVEIMEIIHHFVPTARVLNVVNPTVYICLP--YAYKNCFAQMLYRLETESKELGIHTI 754

Human  1339 GLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQSQASL 1403
            .:.||:||:|||:.:.|...::..:.    ||.|
  Fly   755 SMTDTSLEDVFLRCAGEQDQVDTPDG----SRND------------------------------- 784

Human  1404 QSASSVGSARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLKVR 1468
                             ..:...|:.|.|:|.                     .|.|...|:.|
  Fly   785 -----------------APLLAHYKRLQDHPP---------------------HRGLFQLWMAV- 810

Human  1469 QFHGLLVKRFHCARRNSKALFSQILLPAFFVCV--AMTV--ALSVPEIGDLPPLVLSPS-----Q 1524
                 ..|::...  :::.|::.|:|...||||  |:.|  |:|:.|..:..||.||..     .
  Fly   811 -----FYKKWTFI--SNEWLYTLIMLCIPFVCVFGAILVMHAMSLVENEEALPLKLSQMGSGVIY 868

Human  1525 YHNYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNL 1589
            .||         |..:....|.:||       ||:                  ..||....|::|
  Fly   869 VHN---------PTGHHAHLEQQLR-------QQI------------------ELNGITAKTMHL 899

Human  1590 SSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTAGPEM 1654
            ..                                     |:...:...|||..|::
  Fly   900 RG-------------------------------------SNDVKNESLDLQRDNLA--------- 918

Human  1655 WTSAPSLPRLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNVSEYLLFTSDR 1719
                                                        |.|..:.|
  Fly   919 --------------------------------------------DFLEQVIG------------- 926

Human  1720 FRLHRYGAITFGNVLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAILRA 1784
             .:..||            ...||...|.:         ::||:...|||....:|.:::|:|:.
  Fly   927 -IIDMYG------------GGRGTSDTPTI---------EIFYSGNRYHSSVELINLVDSAMLKL 969

Human  1785 NLPKSKGNPAAYGITVTNHPMNKTSASLS---LDYLLQGTDVVIAIFIIVAMSFVPASFVVFLVA 1846
            ..|:|:       |..|..|:.:..:.:|   |:|        .|:.:.:.|.|....|:.....
  Fly   970 GRPESE-------IDTTYVPIRRFVSDISPSRLEY--------YAVIVPIGMFFFMFYFISLPFR 1019

Human  1847 EKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFV----FDLPA-------YTSP 1900
            |.:...|.||.:|   ...||.|::.:|||          |::||    |.|.:       ||:.
  Fly  1020 EYANGFKQLQTMS---RFTYWFAHFTFDML----------ILIFVCVALFSLQSLMMPSELYTTA 1071

Human  1901 TNFPAVLSLFLLYGWSITPIMYPASFWFEVPS--SAYVFLIVINLFIG--ITATVATFLLQLFEH 1961
            .....|||:| .||.|..||:|.....|:..|  |.|:.|::|...|.  ||::.|. .::|.|
  Fly  1072 ELKVIVLSIF-FYGCSYLPILYALGNNFKSISTISTYLLLMLIVSAIAPLITSSNAA-AMKLHE- 1133

Human  1962 DKDLKVVNSYLKSCFLIF-PNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLV- 2024
                      .|..||.| |::||.|..      ..|||      .|...:.|    .:.:||:
  Fly  1134 ----------TKIAFLCFLPDFNLNHQF------RIINE------NFITRRHP----ALIKGLIS 1172

Human  2025 -------AMAVEGVVGFLLTIMCQYNFLRRP----------QRM------PVSTKPVEDDVDVAS 2066
                   |.||..:|....||:.::.:|||.          ||.      .:.:.|:.:..|.|.
  Fly  1173 QDTFFAYATAVGVMVMAFFTIVLEHKYLRRRIHDGIWEWAFQRKKYNSTGTLPSTPISEIDDCAR 1237

Human  2067 ERQRVLRGDADNDMVK---------IENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGA 2122
            |.:||      .|::|         :.||.|.|     |..||||.:......||||||||||||
  Fly  1238 EEKRV------TDLIKDPLNDHSLIVHNLRKRY-----GDKLAVDGVSFAAAQGECFGLLGVNGA 1291

Human  2123 GKTSTFKMLTGDESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRG 2187
            ||||||:|:..:....||...:.|..:.:..|:.::..|||||.|||...:||.:.|.....|||
  Fly  1292 GKTSTFQMIAANLPLDGGTIRIKGADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRG 1356

Human  2188 I---------SWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEP 2243
            :         |.|:.   ||:.|||:.||||.......||||.||||..|:|:||.||.:.||||
  Fly  1357 LSRRRTDGPASCKEH---VKYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEP 1418

Human  2244 TTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFG 2308
            |||:||.:|||||..|.|.....|:||||||||:|||.||.|||||.:|:.:||.:|..||..
  Fly  1419 TTGVDPISRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRL-- 1481

Human  2309 DGYMITVR----TKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEH--ISLAQVFSKMEQ 2367
            .|:.|.::    |::..:|..:.......||...|:|.|...:.|.:.::.  :..:.||...|:
  Fly  1482 SGFTIKLKMKADTETEMNVSTITGTLKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKIAEE 1546

Human  2368 VSG----VLGIEDYSVSQTTLDNVFVNF---AKKQSDNLEQQETEPP 2407
            ..|    .| :.||||::.||:::|:.|   ||.||.:.:......|
  Fly  1547 YLGDRLSAL-VADYSVNECTLEDIFLKFEREAKSQSTSRQTSVQRRP 1592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA2	NP_997698.1	rim_protein	58..2398	CDD:130324	496/2051 (24%)
		ABC_subfamily_A	1021..1240	CDD:213230	82/220 (37%)
		ABC_subfamily_A	2081..2304	CDD:213230	111/240 (46%)
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	29/159 (18%)
		CcmA	460..767	CDD:224054	107/332 (32%)
		ABC_subfamily_A	461..679	CDD:213230	82/220 (37%)
		ABC2_membrane_3	<937..1117	CDD:289468	56/217 (26%)
		ABC_subfamily_A	1255..1479	CDD:213230	110/231 (48%)
		drrA	1262..1573	CDD:130256	132/321 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148375
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.660