Protein Alignment ABCA2 and CG11147

DIOPT Version :9

• Sequence 1: NP_997698.1
• Gene: ABCA2 / 20
• HGNCID: 32
• Length: 2466
• Species: Homo sapiens
• Sequence 2: NP_608954.1
• Gene: CG11147 / 33803
• FlyBaseID: FBgn0031734
• Length: 711
• Species: Drosophila melanogaster
• Alignment Length: 465
• Identity: 113/465 - (24%)
• Similarity: 203/465 - (43%)
• Gaps: 91/465 - (19%)

Human  2081 VKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVN 2145
            |::.|..|.|.|:...:|: :::|.:.|..|..:||||.:|.|||:....:.|.....|||..|.
  Fly     4 VEVRNGYKYYGSKSNPKIV-LNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNGGEVVVL 67

Human  2146 GHSVLKELLQVQQS-LGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWAL--EKLELT 2207
            |....:....|..| :|:.||..||.:|:|.:|.:..:.|:.|::  ||....|:.|  |.|:|.
  Fly    68 GAKPGEPGSGVPGSRVGFMPQEIALVEEMTVKETIFYFGRIYGLT--DERIREKFKLLKELLQLP 130

Human  2208 KYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGR-SVVL 2271
            . |.:.....|||.:|:||.|.|:|..|..:.|||||.|:||..|..:|:.:::..:..: :|::
  Fly   131 P-ARQMIKQCSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNSKLAVII 194

Human  2272 TSHSMEEC-EALCTRLAIMVNGRLRCLGSIQHLKNRFG-----DGYMITVRTKSSQSVKDVVRFF 2330
            |:|.:||. :|.|  :.:|.||.|....:..::..:||     |.::|..:.:.::.....:...
  Fly   195 TTHYIEEAKQANC--IGLMRNGVLLAEDTPTNIMIKFGTQSIEDAFLILSQRQGNEDELAQIMDH 257

Human  2331 NRN--FPEAMLK-----------------------ERHHTKVQYQLKSEHISL-----AQVFSKM 2365
            |:|  .|.|:|.                       ..:..|:.:..|....:|     .|:|
  Fly   258 NKNQALPAAVLPPEVIDTHEPNMPEKQPIPFEEPLNENRKKIFFTTKGRVKALMTKNFVQLF--- 319

Human  2366 EQVSGVLGIEDYSVSQTTLDNVFV-----------------NFAKKQSDNL--EQQETEPPSALQ 2411
            .|.||::.:..:.:.|.|...:.:                 |:.:...:||  ..::::..|.|.
  Fly   320 RQPSGIIFMLLFPIIQLTCFYLAIGKTPTNLEIGVYSGEVENYGECFDENLVTVYKDSDNESCLF 384

Human  2412 SPLGC-LLSLLRPRSAPTELRALVADEPED--------------------LDTEDEGLISFE--E 2453
            :.|.| .:.:|....|..:..|..||...|                    |...::|:.|.:  .
  Fly   385 NKLSCRYIRVLGDDVATRKYYASEADALNDAKRATTVGYLHFAQNFSDSILSVMEDGIHSSDGAV 449

Human  2454 ERAQLSFNTD 2463
            :.|:||.:.|
  Fly   450 DHAELSIHID 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA2	NP_997698.1	rim_protein	58..2398	CDD:130324	94/373 (25%)
		ABC_subfamily_A	1021..1240	CDD:213230
		ABC_subfamily_A	2081..2304	CDD:213230	74/227 (33%)
CG11147	NP_608954.1	CcmA	1..282	CDD:224054	83/283 (29%)
		P-loop_NTPase	4..222	CDD:304359	74/223 (33%)
		ABC2_membrane_3	322..702	CDD:289468	24/138 (17%)
		ABC2_membrane	469..664	CDD:279410

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810