Protein Alignment ABCA2 and ABCA

DIOPT Version :9

• Sequence 1: NP_997698.1
• Gene: ABCA2 / 20
• HGNCID: 32
• Length: 2466
• Species: Homo sapiens
• Sequence 2: NP_608445.2
• Gene: ABCA / 33103
• FlyBaseID: FBgn0031170
• Length: 1714
• Species: Drosophila melanogaster
• Alignment Length: 1899
• Identity: 580/1899 - (30%)
• Similarity: 904/1899 - (47%)
• Gaps: 416/1899 - (21%)

Human   587 QLDTIDNAACGWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPH 651
            :|||:...|...:||              :::..|.|.|.                    .||..
  Fly   140 ELDTVSKNAFAGVQF--------------DDAWANLTEND--------------------PLPND 170

Human   652 VHYKIRQNSSFTEKTNEIRRAYW---------------RPGPNTGG--RFYFLYGFVWIQDMMER 699
            .|:.:|..:.....|..|... |               ..|.:.||  ..|...||:.:|..:..
  Fly   171 FHFALRFPAELRTATIAIANT-WLTMRLFPTIDLTGPRNEGDDDGGIPPGYLREGFLPLQHSLSM 234

Human   700 AIIDTFVGHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHR 764
            |.:....|...: |...::.:|:|.|..|..|..:..:|.|.:::|::|......::|.||||.:
  Fly   235 AYLRQKSGEQDL-PNVVMKRYPFPAYIFDPLLEGMSSIMSLIILLSFIYPCTYITKYITAEKEKQ 298

Human   765 LKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYG-----QVLMHSHVVIIWLFLAVYA 824
            ||||||.|||:|.:||.|||:..|:.|:||...:..::|..     .||.|::...:..||.:|.
  Fly   299 LKEVMKIMGLSNWLHWTAWFVKSFIMLTISAILIAILVKINWSEDVAVLTHANFTALVFFLIIYI 363

Human   825 VATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAF 889
            |::|.|||:::..:|:|..|:|..|:|:|::|:||.:..    .::|.::...|...||:|.||.
  Fly   364 VSSICFCFMMATFFSRASTAAAVTGLIWFIAYIPYSFTI----NSYDDLSLSSKLGWSLISNTAM 424

Human   890 GLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAV-TMLMVDAVVYGILTWYIEAVHPGMYG 953
            |.|.|....:|..|.|:||..|. :||..||...|.|| .|::|..|:|.|:..|:|.|.||.:|
  Fly   425 GFGIKLILGFEGTGEGLQWSNFF-TPVSVDDTLTLGAVMIMMLVSCVIYMIICLYVEQVMPGSFG 488

Human   954 LPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEEEPTHLP 1018
            :||||.||..:.:|.|.......|      ..|...|.:.|            .:..|.||....
  Fly   489 VPRPWNFPFTREFWCGEREYTGVE------DIPNGHVEQRD------------PKAFETEPEGKH 535

Human  1019 LVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYG 1083
            :.:.:..|.|.:  ..|:.:..||:|::|:::...|||||||||||:|:|||:||||||:|.|.|
  Fly   536 IGLQMRHLKKRF--GNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIING 598

Human  1084 HDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRH 1148
            .||||.::..|.:||:|||||||||.::|..|:.|:||:|.:..:.:.:|:.|.::.:||.:|.:
  Fly   599 SDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKAN 663

Human  1149 SLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMD 1213
            .....|||||||||||..|..|.::.::.|||::|:||.|||.:|||:.:.|.|||:||:||.||
  Fly   664 VASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFMD 728

Human  1214 EADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSS 1278
            |||:|||||||:..|:|||.|:..|||..||.||||..|||                      ..
  Fly   729 EADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKR----------------------DD 771

Human  1279 CSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDT 1343
            |...:|:..:.|::.......|...||||.||..|:.|  ||.:|..||...|.|||:.:|:..|
  Fly   772 CETNEVTALLNKYIPGLKPECDIGAELSYQLPDSASAK--FEEMFGQLEEQSDELHLNGYGVGIT 834

Human  1344 TLEEVFLKVSEEDQSLENSEADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQSQASLQSASS 1408
            ::||||:||..|    :::..::|: :.:::.|..|
  Fly   835 SMEEVFMKVGAE----KDNTGNIKD-QHEIMNGGSG----------------------------- 865

Human  1409 VGSARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLKVRQFHGL 1473
               .||::                     ||   :.|:::.:  ..:..|.|.|..|...|:..:
  Fly   866 ---FRGED---------------------DN---ESVQSDGI--FSENRRLLQGLQLLSNQWKAM 901

Human  1474 LVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQPRGNFIPY 1538
            |:|:|....||...|..|.::|.|||.|.:.:..:.....:|.|:.:|.:||           |.
  Fly   902 LLKKFLYTWRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITISLTQY-----------PL 955

Human  1539 ANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNLSSGESRLLAARFFD 1603
            |                               .|.:.:|          |:.:|....:|.::
  Fly   956 A-------------------------------VTVLDRS----------NVQNGTGYEIANKY-- 977

Human  1604 SMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTAGPEMWTSAPSLPRLVREP 1668
                                             |||
  Fly   978 ---------------------------------EDL----------------------------- 980

Human  1669 VRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITG-HNVSEYLLFTSDRFRLHRYGAITFGN 1732
                  |:..|    |:.|              .::|| ....:|:|                 :
  Fly   981 ------ARSYG----SNYG--------------LELTGTQGFEDYIL-----------------D 1004

Human  1733 VLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYG 1797
            :.|:|.....:|.  :|...........:.||:..|:.|..:|.::|||      ..|...::..
  Fly  1005 LGKTIQVRINSRY--LVAATITESKITAWLNNQALHTAPLTVNMVHNAI------ADKLFGSSVK 1061

Human  1798 ITVTNHPMNKTSASLSLDYLLQGTDV--VIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSG 1860
            |.|||.|:..|:::| |..|..|.::  .:|..:...|.||.:.:::||:.|:.::||.||||.|
  Fly  1062 IQVTNAPLPYTTSTL-LSQLSTGNNLGTQLASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGG 1125

Human  1861 CNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPAS 1925
            .....:||:.::.|..:|:|.|...||.:..|.....::.........|.||:|:::.|.:|..|
  Fly  1126 VKVWTFWLSQFICDFASYIVTALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMS 1190

Human  1926 FWFEVPSSAYVFLIVINLFIGITATVATFLL--QLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGL 1988
            .:|..|::.:..:.::|:|.|:...:...::  :||    |.|.....|...|.|||:::|...|
  Fly  1191 LFFREPATGFARVSIVNIFCGMALFIVVVVMSSELF----DTKDTADILGWIFRIFPHFSLAMSL 1251

Human  1989 MEMAYNEYINEYYAKIG------------QFDKMKSPFEWDI--VTRGLVAMAVEGVVGFLLTIM 2039
            .::..|.......||.|            |...:|..|.|:.  |....|.|||.|||.||:.|:
  Fly  1252 NKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGVVFFLIIIV 1316

Human  2040 CQYNFLR-----------RPQRMPVSTKPVEDDVDVASERQRVLRGDADNDMVK---IENLTKVY 2090
            .::..:.           :|.  |..|:...|| |||:||:|:|:..::....|   ::.:||.|
  Fly  1317 LEFRLINELMFKIRQLISKPP--PPPTEGQLDD-DVANERERILQMSSNELATKNLVLDRVTKYY 1378

Human  2091 KSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKELLQ 2155
                 |:.:||:::.|.|:..||||||||||||||:||||:||||..:.|.|:|.|.|:...:..
  Fly  1379 -----GQFMAVNQVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNS 1438

Human  2156 VQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWA---LEKLELTKYADKPAGTY 2217
            :.:.:|||||.|||.|:||.||.|:::..|||:   .|:|:.:.:   .:.....|:.||....|
  Fly  1439 IYKMIGYCPQFDALLDDLTGREVLRIFCMLRGV---QESRIRQLSEDLAKSFGFMKHIDKQTHAY 1500

Human  2218 SGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEAL 2282
            |||||||||||||:||.|:.|:||||||||||.|||.|||::..:..:|:|:|||||||||||||
  Fly  1501 SGGNKRKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEECEAL 1565

Human  2283 CTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTK----------------------------S 2319
            ||||||||||..:|:||.|||||:|..|.::.::.:                            |
  Fly  1566 CTRLAIMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMS 1630

Human  2320 SQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSGVLGIEDYSVSQTTL 2384
            .:.:..|..|....:|.::|:|.:...:.:.:....:..:::|..||.....|.:||||||||||
  Fly  1631 QRDIDAVKEFVETEYPNSILQEEYQGILTFYIPLTGVKWSRIFGLMESNRDQLNVEDYSVSQTTL 1695

Human  2385 DNVFVNFAKKQSDN 2398
            :.:|:.|||.|.::
  Fly  1696 EEIFLEFAKYQRED 1709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA2	NP_997698.1	rim_protein	58..2398	CDD:130324	580/1897 (31%)
		ABC_subfamily_A	1021..1240	CDD:213230	109/218 (50%)
		ABC_subfamily_A	2081..2304	CDD:213230	122/228 (54%)
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	65/183 (36%)
		ABC2_membrane_3	<269..475	CDD:289468	77/210 (37%)
		CcmA	538..843	CDD:224054	147/330 (45%)
		ABC_subfamily_A	538..755	CDD:213230	109/218 (50%)
		ABC2_membrane_3	913..1316	CDD:289468	117/572 (20%)
		ABC_subfamily_A	1369..1587	CDD:213230	121/225 (54%)
		drrA	1376..1702	CDD:130256	146/333 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148384
Domainoid	1	1.000	161	1.000	Domainoid score	I4008
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.660