Protein Alignment ABCA2 and CG1494

DIOPT Version :9

• Sequence 1: NP_997698.1
• Gene: ABCA2 / 20
• HGNCID: 32
• Length: 2466
• Species: Homo sapiens
• Sequence 2: NP_001259763.1
• Gene: CG1494 / 33102
• FlyBaseID: FBgn0031169
• Length: 1695
• Species: Drosophila melanogaster
• Alignment Length: 1970
• Identity: 406/1970 - (20%)
• Similarity: 731/1970 - (37%)
• Gaps: 575/1970 - (29%)

Human   612 GFPD----EESIVNYTLNQAYQDNVTVFASVIFQTRKDGS------------------LPPHVHY 654
            ||.|    .||::...|          ||.:.|    |||                  :.|.::|
  Fly   126 GFEDCEEMRESVIENGL----------FAGLCF----DGSPFVEDQVFEEDTLESYSNIQPMLNY 176

Human   655 KIRQNSSFTEKTNEIRRAYW----RPGPNT-----------GGRF-YFLYGFVWIQDMMERAIID 703
            .|...|.......:.|.|.|    ...|||           ||.. |...||:.:|..:..:.:
  Fly   177 TILLPSELRMLDGDFRMANWMTLYNDDPNTFVLTRLNQPYEGGFVGYVREGFIRLQKSVSESFL- 240

Human   704 TFVGHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEV 768
            ....|..: |...::.||.....:|..:..:.:.||..::|.:::...:.:..:|:||:.::::.
  Fly   241 VLTSHKSL-PTIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFVWQVVSEKQSQVRQF 304

Human   769 MKTMGLNNAVHWVAWFITGFVQLSISVTALTAILK------YGQVLMHSHVVIIWLFLAVYAVAT 827
            :..|.:.|.:|:|:|::.|.:...||...:.|:||      :| ||..:...|:.|.|..|..|.
  Fly   305 LINMNIGNLIHFVSWYLKGLIYEMISSLIIAALLKIRWDQDHG-VLTQTPWYILILVLFCYNCAA 368

Human   828 IMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREE--------VAHDKITAFEKCIASLM 884
            :.|..:|:..:..|..|.....|::.:||||...::...|        |::    |....:|:|:
  Fly   369 VAFAIMVAAFFRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALRYVSY----ALPNVVATLV 429

Human   885 STTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHP 949
            ........|.....:|.:|..:.:        :|....:..:..:.|::|:||..:..|::
  Fly   430 IEFLIERESIVHITWEDSGYRLNY--------DGGHITVTASSWIFMLNALVYCAIGLYVD---- 482

Human   950 GMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSV-MEED-------------QACAME 1000
                            .|.|..|      |....:.|..:. ::||             ||..:.
  Fly   483 ----------------MWRGGDR------SGKKMKKPNTNASVQEDPYHERGDSFTHQGQAIGVN 525

Human  1001 SRRFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTM 1065
            |     |:..|.||:|....:.:.||.|.:..:.:.|||..|.|:|||:|...:||||.||:|.:
  Fly   526 S-----TKIYEVEPSHRRFKLKIKKLCKRFATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLL 585

Human  1066 SILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQE-E 1129
            .||.||..|:.|:..|..|:|:||.......||:...|::|....||.::|.|..|:|.:... |
  Fly   586 KILAGLVEPSRGTVMISSHNIQTERKAASMELGIAFGHDMLLTGFTVIDYLRFICRVKGLHNNIE 650

Human  1130 IRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWD 1194
            |..:.:..:..|::...:...::||:......:|:..||||.|..|::|:..:.:|...:..:|:
  Fly   651 IDGQSNYFLNVLQIGGLKTKRIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWN 715

Human  1195 LILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPG 1259
            ||.:.|..|||:|.::....|:.:.||:||:|:|:|||.|:..|||..||.|||||.||
  Fly   716 LINEEKSKRTIILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVK------ 774

Human  1260 GPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQ 1324
                        |:    :....::...:..::.:..:..|...:::::|  |...:..|..|..
  Fly   775 ------------GK----NYKRDELFGMMNSYMPNMSIERDIGYKVTFVL--ENKFEDQFPMLID 821

Human  1325 HLERSLDALHLSSFGLMDTTLEEVFLKVSEED-------QSLENSEADVKESRKDVLPGAEGPAS 1382
            .||.::..|.:.||.:.||::||:||:...||       ||.||::..::|
  Fly   822 DLEENMQQLGVVSFRIRDTSMEEIFLRFGCEDNDQSGAFQSHENAQVLLEE-------------- 872

Human  1383 GEGHAGNLARCSELTQSQASLQSASSVGSARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEA 1447
               :...||..:|
  Fly   873 ---YYSTLAEANE---------------------------------------------------- 882

Human  1448 EALSRVGQGSRKLDGGWLKVRQFHG--LLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVP 1510
                   :|.|.   || |:...||  ::.||:..|.|:...|..::|..|.   ||:....|:.
  Fly   883 -------KGRRT---GW-KLFFLHGRAVIYKRWIAAHRHWIVLIFEVLAMAL---VAVCTFSSIF 933

Human  1511 EIG---DLPPLVLSPSQYHNYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGAT 1572
            ..|   :|.||..:.||.|.                                |..|
  Fly   934 IYGKNYELEPLTFNLSQLHT--------------------------------VDAF--------- 957

Human  1573 CVLKSPANGSLGPTLNLSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDE 1637
                          :.|.|.|..:                                        :
  Fly   958 --------------VELFSEEEDV----------------------------------------K 968

Human  1638 DLQAWNVSLPPTAGPEMWTSAPSLPRLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILT 1702
            |:.|:...|      ..|..|                                   .|.|
  Fly   969 DMHAYYTEL------LYWYDA-----------------------------------HVAT----- 987

Human  1703 DITGHNVSEYLLFTSDRFRLHRYGAITFGNVLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGY 1767
             :|.:..:.|.|.|.::|..|......||       |:|.            ::....::||...
  Fly   988 -LTKNRHNAYALLTQNQFTAHVNSRYIFG-------ATFD------------QKIVTAWFNNIPL 1032

Human  1768 HSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGTDVVIAIFIIVA 1832
            ||.|..||.::||:.|....:..      .|.||..|:...:|..:...........:|..|...
  Fly  1033 HSAPYALNVVHNAVARHLFDEEA------TIDVTLAPLPFRTAINTFPPSSHTFGGCLAFGICFV 1091

Human  1833 MSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAY 1897
            ::|:..:|.::::.|:.:..|..||::|.....||....::|:|..|:...|.|:::.:::.|.:
  Fly  1092 LTFIWPAFAIYMITERGSLLKKQQFLAGVRVCSYWTFTVLYDLLFLLIFCACVVVMVALYENPNH 1156

Human  1898 TSPTNFPAVLSLFLLYGW-SITPIMYPASFWFEV-----------PSSAYVFLIVINLFIGITA- 1949
            .           .:|||: |:|.::  ..||..:           |...:::|..|| .||:..
  Fly  1157 D-----------VMLYGYISVTLML--GGFWVILLAYLMASLCRNPCYGFLWLCGIN-SIGLVCF 1207

Human  1950 ---------------------TVATFLLQLF-------------------EHDKDLKVVNSYLKS 1974
                                 ||||.:.:||                   |..|...:.|..:||
  Fly  1208 SQFYRTHPESMLLEPTFMAMYTVATVICKLFMIYEFKLICMDPVVNFTSVEVFKCNSIPNCCIKS 1272

Human  1975 CFLIFPNYNLGHGLMEMAYNE-------YINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAVEGVV 2032
            .:..| ...:.|.|:.:...:       :::||::.:|..|
  Fly  1273 NYGTF-TAGIYHDLVILTLLDIILLACLFVSEYHSILGFAD------------------------ 1312

Human  2033 GFLLTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQRVLRGDADND---MVKIENLTKV----- 2089
                   |         |:...|....|    :::..|...|...||   :|..|:.:::
  Fly  1313 -------C---------RLDTRTNESPD----SNQESRAFPGILSNDTAALVDKEHTSRLNEEER 1357

Human  2090 --YKSRKIGRILAVDR------LCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNG 2146
              |.:..||.:....|      |...:...||..:.|.|.:|||:..|::..:.....|:.:::.
  Fly  1358 SKYAAVGIGIVSKYRRNRVLRDLDFTLAKSECLSITGANNSGKTTLLKVVVNETKMNAGQLWIHD 1422

Human  2147 HSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYAD 2211
            :||....:|..:.:|||||.|:|..|.|.||.|.::..|:|...:....:.:..|..:.||...:
  Fly  1423 YSVNTHRVQCYRMVGYCPQKDSLPSEFTPRELLYIHAMLQGHRHRIGRELSEALLRLVGLTPCWN 1487

Human  2212 KPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSM 2276
            :.....:.|..|:|..|.|::|.|..|.:|....|:||..:|.:..:...:...|.|.:.|..:.
  Fly  1488 RSVRMCTTGQIRRLYFAYAVLGSPDLICVDGVPAGLDPTGKRIILMMTSTMQAMGSSFLYTMLTG 1552

Human  2277 EECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTK--------SSQSVKDVVRFF--- 2330
            .:.|.|..|..:::.|:|..:..:......:..||.:.||.|        .|::..:::..|
  Fly  1553 LDAERLSLRTPLLLEGQLWMIRPMDTETENYKSGYQLEVRFKRKVNPNVSMSRATWNLINHFPMS 1617

Human  2331 -NR--------NFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLDN 2386
             |:        .||:|:|.......:.:.|.....:.:::|..:.:.:..:.||||.:::    |
  Fly  1618 PNKKFSAFMEIKFPDAVLTIERDDSMVFVLPLGTTTFSEIFLTLRKDAFEMNIEDYFITR----N 1678

Human  2387 VFVNFAKKQSDNLEQQETEP 2406
            :.|.|   |....:|.:..|
  Fly  1679 MLVGF---QIFTYDQHQDNP 1695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA2	NP_997698.1	rim_protein	58..2398	CDD:130324	404/1960 (21%)
		ABC_subfamily_A	1021..1240	CDD:213230	74/219 (34%)
		ABC_subfamily_A	2081..2304	CDD:213230	57/235 (24%)
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	48/229 (21%)
		CcmA	541..848	CDD:224054	101/330 (31%)
		ABC_subfamily_A	541..761	CDD:213230	74/219 (34%)
		ABC2_membrane_3	911..>1189	CDD:289468	74/460 (16%)
		ABC2_membrane	<1080..>1188	CDD:304374	24/120 (20%)
		ABC_subfamily_A	1370..1577	CDD:213230	52/206 (25%)
		PRK14255	1371..1586	CDD:172743	52/214 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148382
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750