DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA2 and CG34120

DIOPT Version :9

Sequence 1:NP_997698.1 Gene:ABCA2 / 20 HGNCID:32 Length:2466 Species:Homo sapiens
Sequence 2:NP_001285513.1 Gene:CG34120 / 318066 FlyBaseID:FBgn0083956 Length:1998 Species:Drosophila melanogaster


Alignment Length:2236 Identity:495/2236 - (22%)
Similarity:798/2236 - (35%) Gaps:700/2236 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   436 FVQLWAGLQPILCGN-----------NRTIEPEALRRGNMSSLGFTSKEQR-------------- 475
            ||:|..    :|||:           |..:|.|...:.|.:.:......:|              
  Fly   181 FVKLGV----LLCGHPFPNTDTIPLVNEILESEDFSQANDAEIDAMPTRRRRRYEDLPTDWRPTK 241

Human   476 ------------NLGLLVHLMTSNP----KILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWL 524
                        |.|.|. ..|..|    :|||.||.:..:.|:..:|                 
  Fly   242 YCKRLYRDVTSTNQGKLT-WNTIKPIIQGRILYTPANAMTESVVKFSN----------------- 288

Human   525 NISAEIRSFLEQGRLQQHLRWLQQYVAEL--RLHPEA---------LNLSLDELPPALRQDNFSL 578
                  .||.|..||:|    |.:..|.:  :||..|         |.|:...|..:|..|:|.:
  Fly   289 ------ASFEELDRLKQ----LSRAAATILTKLHTNATFQEAFDNLLKLAKSPLVKSLVGDDFDI 343

Human   579 PSGMALLQQL-------DTIDNAACGWIQFMSKVSVDIFKGFPDEESIVN--YTLNQAYQDNVTV 634
            .....:.:.:       |.:...|    ..|..||.|.|:.....|.:..  |.|||    |...
  Fly   344 GEIERVFEYIRTNQLIYDILTTVA----DLMDCVSADRFEAVESVEELHKRAYELNQ----NKLF 400

Human   635 FASVIFQTRKDGSLPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLY--GFVWIQDMM 697
            .|::   ..:|..| ....|::..::..|:.|.|.|..:|.|||.........|  |||.::.|:
  Fly   401 LAAL---NLEDVGL-KQASYRLHMDTDNTQPTFENRNRFWFPGPADSMVIDLKYHRGFVQLKQMV 461

Human   698 ERAII----------------------------------------DTF----------------- 705
            :..||                                        |.|                 
  Fly   462 DLGIIKSKREEAGFAPEEDGPESGRSLSGLFSIKQVENDTPDEDDDDFDLSLEESGDEKAAPKVS 526

Human   706 ---VGHD--VVEPGS-------------------------------------------------- 715
               ..|:  .:.|.|                                                  
  Fly   527 ASASDHEATTISPSSLDGVTTEEVRVTTEQTVVSGDPDLLLLKNEDVLKRSKRQGLFDLLGGFGG 591

Human   716 -----------------YVQMFPYPCYTRDDF---LFVIEHMMPLCMVISWVYSVAMTIQHIVAE 760
                             |.:.||||.:..|.|   |::.:.:. :..::..|..||::::..:..
  Fly   592 SGDANKKNKFEVDNMQFYTKQFPYPAFLNDVFKRGLYLAQGVQ-VAYLLGLVVFVALSVRERIWM 655

Human   761 KEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAV 825
            :|.|...:|::|||......|||.:..|::|.:....::.:|..|.:|.:::    |.|:..|.:
  Fly   656 RESRNSMLMRSMGLKAHSELVAWALMSFLELCVIFALISGVLYSGGILGYTN----WFFMMFYCL 716

Human   826 A----TIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMST 886
            :    .|.||::.:..::.|.:.:....:::|:|..|::.|.:.:.    |::.||..:..|..|
  Fly   717 SFGLCLISFCYMCTNFFNSANIGAVASALLFFISLCPFIIVLMFDA----KLSVFESFLVDLSFT 777

Human   887 TAFGLGSKYFALYEVAGVGIQ-WHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPG 950
            |||..|.......|:...|:. .|.....|...:   ..:|:.|.::|.::|.::          
  Fly   778 TAFAKGWGELIRMELQQEGLTVRHLIQVGPARSE---CAMALLMFLLDLLLYAVI---------- 829

Human   951 MYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEEEPT 1015
              ||....|                       .:|...|.::..:: .::.:             
  Fly   830 --GLAYQRY-----------------------KKTDNYSFVKVSRS-QLDGK------------- 855

Human  1016 HLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSAT 1080
               |...:..::|:|  ..|.|::.|||:...|||...||.|||||:|.:.:|||....:||...
  Fly   856 ---LGASLVNVSKLY--GSKCAVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVL 915

Human  1081 IYG-HDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLK-----SMAQEEIRREMDKMIE 1139
            :.| |.:           |:|.|.|:|...||..|||..|:::|     |...||||.|:.:.::
  Fly   916 LAGEHQV-----------GVCWQDNILIPTLTAREHLQLYAQIKIPPGGSGGVEEIRSEVAQTLQ 969

Human  1140 DLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRT 1204
            .|............||||.:|:|.|||||:.....:|||||..|||..||:.||.||.:.:.||.
  Fly   970 SLNFGKHESYPSWQLSGGYRRRLCVAIAFIASPSVVILDEPCNGVDAKARKDIWQLIERLRQGRA 1034

Human  1205 ILLSTHHMDEADLLGDRIAIISHGKL----------KCCGSPLFLKGTYGDGYRLTLVKRPAEPG 1259
            ::.:||.||||..|.|.:.|:.:|::          :.|.|...::....|...:|.|.:.|:..
  Fly  1035 VIFATHFMDEAKYLSDSLVIMRNGRIIAQHSRDSLQRLCTSNYSIRLRCADATGVTFVIQKAQQL 1099

Human  1260 GPQ----EPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFE 1320
            .||    ..|.|..|         ..|.::....:|:.                      .||.|
  Fly  1100 LPQTQVTHSGAADYP---------HSLTINASYAEHLT----------------------PGAVE 1133

Human  1321 RLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDVLPGAEGPASGEG 1385
                                        ||::. :.|....|.:||                   
  Fly  1134 ----------------------------FLELL-QSQVTAGSISDV------------------- 1150

Human  1386 HAGNLARCSELTQSQASLQSASSVGSARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEAL 1450
                     |||.|.:..|....:.  |..|.||              |:.|         |...
  Fly  1151 ---------ELTTSSSLEQEFEQLN--RNGEDAG--------------PRRP---------ASDR 1181

Human  1451 SRVGQGSRKL-DGGWLKVRQFHGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGD 1514
            |.|..|...: |......:||..|:.||.....||.:.|...:||||.|...||.          
  Fly  1182 SGVVAGPAMITDEPPTACKQFRLLMGKRLRHLSRNYRLLLYVLLLPALFELCAMW---------- 1236

Human  1515 LPPLVLSPSQYHNYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPA 1579
                                |:.|..|:..:..|.||....||                      
  Fly  1237 --------------------FVSYRLEDDFDTVLPLSRSLYPQ---------------------- 1259

Human  1580 NGSLGPTLNLSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNV 1644
                              .|:|.......||::.|                              
  Fly  1260 ------------------TAQFLSHERATSFSEKL------------------------------ 1276

Human  1645 SLPPTAGPEMWTSAPSLPRLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNV 1709
                            .|:|     |.:|.              |..:.||..       |....
  Fly  1277 ----------------YPQL-----RTSCD--------------HLGECRVFN-------TSQQS 1299

Human  1710 SEYLLFTSDRFRLHRYGAITFGNVLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGYHSMPTYL 1774
            .:::|.:...:...|||             .:|...          ..|.|:|||||||||..:|
  Fly  1300 YDWVLNSWGEYSERRYG-------------GYGLNG----------SGATVWYNNKGYHSMMAWL 1341

Human  1775 NSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLL-QGTDVVIAIFIIVAMSFVPA 1838
            |.||:.:||..:     |.:...|...|.|.....|.||...:| |..|..:...:::|...|.|
  Fly  1342 NDLNSELLRTTM-----NDSESSILTLNEPWKLGFAELSTSSILRQAGDGSMVFILLIAFGLVVA 1401

Human  1839 SFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNF 1903
            |..|:||.|:....|..|.:.|.:.:.|||...|||.|..::....|::::.:|.:|.:......
  Fly  1402 SGSVYLVNERVNGEKLQQRLCGVSAVTYWLVALVWDYLVMVLGLIVCLVVILMFGMPVFVDRQQL 1466

Human  1904 PAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVV 1968
            ..::.|.|.:.::..|.::.|...|...|.|.|.:...||.:.: .|:...|:        |.||
  Fly  1467 VGIIGLSLAFSFACVPSVHVAEKIFSDSSIAIVSIFCANLIVPL-VTMGIILI--------LGVV 1522

Human  1969 NS---------YLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLV 2024
            ..         .|...|||||.:.||.|.:|:..|..:...:.:. ..|..|.|...|::.|...
  Fly  1523 GDGPAWDDWRHALNQAFLIFPIHALGDGFLELCKNYMVALVFRRY-DIDSYKHPLASDLLGRHFT 1586

Human  2025 AMAVEGVVGFLLTIMCQYNFLRRP-QRMPVSTKPVEDDVDVASER-------------QRVLRGD 2075
            |:.:.||...::.::.:::.|||. ||       ||..:|....|             |.:.:..
  Fly  1587 ALLLVGVAALIINVLIEWHLLRRLWQR-------VERLLDCTYRRELDKLGQLKLVNIQSIFKSC 1644

Human  2076 AD-NDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTG 2139
            .| .:.|:.|||...|:...    .||..:...|:.||||||||.|||||::.||:|||......
  Fly  1645 VDTGEAVRAENLWLAYRRGH----YAVRNVNFSVQRGECFGLLGKNGAGKSTIFKLLTGQLQPDV 1705

Human  2140 GEAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKL 2204
            |:.:..           |..:.||||.:.|...||..|.::.|.|||||  :|..:.:...|:..
  Fly  1706 GQIYFE-----------QPGISYCPQSNPLDPLLTTTECIRFYGRLRGI--RDLDQFLDRVLDTY 1757

Human  2205 ELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSV 2269
            ||..|.|......||||:|||:.|:...|....:.:||||:.|||..|..::..|..|:...|:|
  Fly  1758 ELRPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMDEPTSDMDPVTRDMVYATIEQLLLARRAV 1822

Human  2270 VLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFNRNF 2334
            ||||||:.|.|.||.|:|::..|::....|.|.||:..|..|.:|.....:|.. .:.|..|:..
  Fly  1823 VLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLKSEHGGYYAVTCFCGPAQQA-ILSRSLNQRL 1886

Human  2335 PEAMLKERHHTKVQYQLK-------SEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFA 2392
            |.|...:.:...:::.::       .:...|:::|:.:..|  .:.:..:|:|:...:.||....
  Fly  1887 PGARDLQHYAHSLRFLVRVRSPGSLGDAPLLSELFAILCDV--CVNVARFSLSRCRFETVFERIL 1949

Human  2393 KKQSDN------LEQQETEPPSALQS 2412
            .....|      .:||:....:.|.|
  Fly  1950 DSSESNGSNGVHKDQQQQVAKNDLPS 1975

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCA2NP_997698.1 rim_protein 58..2398 CDD:130324 490/2214 (22%)
ABC_subfamily_A 1021..1240 CDD:213230 83/234 (35%)
ABC_subfamily_A 2081..2304 CDD:213230 84/222 (38%)
CG34120NP_001285513.1 ABC2_membrane_3 <621..760 CDD:289468 31/143 (22%)
ABC_subfamily_A 859..1073 CDD:213230 81/226 (36%)
drrA 865..1162 CDD:130256 108/397 (27%)
ABC2_membrane_3 1230..1601 CDD:289468 111/550 (20%)
Mem_trans 1436..>1552 CDD:304621 30/124 (24%)
ABC_subfamily_A 1651..1857 CDD:213230 84/222 (38%)
drrA 1666..1945 CDD:130256 94/294 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148360
Domainoid 1 1.000 134 1.000 Domainoid score I5010
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.650

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