DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA2 and ldd

DIOPT Version :10

Sequence 1:NP_997698.1 Gene:ABCA2 / 20 HGNCID:32 Length:2466 Species:Homo sapiens
Sequence 2:NP_001285513.1 Gene:ldd / 318066 FlyBaseID:FBgn0083956 Length:1998 Species:Drosophila melanogaster


Alignment Length:2236 Identity:495/2236 - (22%)
Similarity:798/2236 - (35%) Gaps:700/2236 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   436 FVQLWAGLQPILCGN-----------NRTIEPEALRRGNMSSLGFTSKEQR-------------- 475
            ||:|..    :|||:           |..:|.|...:.|.:.:......:|              
  Fly   181 FVKLGV----LLCGHPFPNTDTIPLVNEILESEDFSQANDAEIDAMPTRRRRRYEDLPTDWRPTK 241

Human   476 ------------NLGLLVHLMTSNP----KILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWL 524
                        |.|.|. ..|..|    :|||.||.:..:.|:..:|                 
  Fly   242 YCKRLYRDVTSTNQGKLT-WNTIKPIIQGRILYTPANAMTESVVKFSN----------------- 288

Human   525 NISAEIRSFLEQGRLQQHLRWLQQYVAEL--RLHPEA---------LNLSLDELPPALRQDNFSL 578
                  .||.|..||:|    |.:..|.:  :||..|         |.|:...|..:|..|:|.:
  Fly   289 ------ASFEELDRLKQ----LSRAAATILTKLHTNATFQEAFDNLLKLAKSPLVKSLVGDDFDI 343

Human   579 PSGMALLQQL-------DTIDNAACGWIQFMSKVSVDIFKGFPDEESIVN--YTLNQAYQDNVTV 634
            .....:.:.:       |.:...|    ..|..||.|.|:.....|.:..  |.|||    |...
  Fly   344 GEIERVFEYIRTNQLIYDILTTVA----DLMDCVSADRFEAVESVEELHKRAYELNQ----NKLF 400

Human   635 FASVIFQTRKDGSLPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLY--GFVWIQDMM 697
            .|::   ..:|..| ....|::..::..|:.|.|.|..:|.|||.........|  |||.::.|:
  Fly   401 LAAL---NLEDVGL-KQASYRLHMDTDNTQPTFENRNRFWFPGPADSMVIDLKYHRGFVQLKQMV 461

Human   698 ERAII----------------------------------------DTF----------------- 705
            :..||                                        |.|                 
  Fly   462 DLGIIKSKREEAGFAPEEDGPESGRSLSGLFSIKQVENDTPDEDDDDFDLSLEESGDEKAAPKVS 526

Human   706 ---VGHD--VVEPGS-------------------------------------------------- 715
               ..|:  .:.|.|                                                  
  Fly   527 ASASDHEATTISPSSLDGVTTEEVRVTTEQTVVSGDPDLLLLKNEDVLKRSKRQGLFDLLGGFGG 591

Human   716 -----------------YVQMFPYPCYTRDDF---LFVIEHMMPLCMVISWVYSVAMTIQHIVAE 760
                             |.:.||||.:..|.|   |::.:.:. :..::..|..||::::..:..
  Fly   592 SGDANKKNKFEVDNMQFYTKQFPYPAFLNDVFKRGLYLAQGVQ-VAYLLGLVVFVALSVRERIWM 655

Human   761 KEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAV 825
            :|.|...:|::|||......|||.:..|::|.:....::.:|..|.:|.:::    |.|:..|.:
  Fly   656 RESRNSMLMRSMGLKAHSELVAWALMSFLELCVIFALISGVLYSGGILGYTN----WFFMMFYCL 716

Human   826 A----TIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMST 886
            :    .|.||::.:..::.|.:.:....:::|:|..|::.|.:.:.    |::.||..:..|..|
  Fly   717 SFGLCLISFCYMCTNFFNSANIGAVASALLFFISLCPFIIVLMFDA----KLSVFESFLVDLSFT 777

Human   887 TAFGLGSKYFALYEVAGVGIQ-WHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPG 950
            |||..|.......|:...|:. .|.....|...:   ..:|:.|.::|.::|.::          
  Fly   778 TAFAKGWGELIRMELQQEGLTVRHLIQVGPARSE---CAMALLMFLLDLLLYAVI---------- 829

Human   951 MYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEEEPT 1015
              ||....|                       .:|...|.::..:: .::.:             
  Fly   830 --GLAYQRY-----------------------KKTDNYSFVKVSRS-QLDGK------------- 855

Human  1016 HLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSAT 1080
               |...:..::|:|  ..|.|::.|||:...|||...||.|||||:|.:.:|||....:||...
  Fly   856 ---LGASLVNVSKLY--GSKCAVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVL 915

Human  1081 IYG-HDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLK-----SMAQEEIRREMDKMIE 1139
            :.| |.:           |:|.|.|:|...||..|||..|:::|     |...||||.|:.:.::
  Fly   916 LAGEHQV-----------GVCWQDNILIPTLTAREHLQLYAQIKIPPGGSGGVEEIRSEVAQTLQ 969

Human  1140 DLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRT 1204
            .|............||||.:|:|.|||||:.....:|||||..|||..||:.||.||.:.:.||.
  Fly   970 SLNFGKHESYPSWQLSGGYRRRLCVAIAFIASPSVVILDEPCNGVDAKARKDIWQLIERLRQGRA 1034

Human  1205 ILLSTHHMDEADLLGDRIAIISHGKL----------KCCGSPLFLKGTYGDGYRLTLVKRPAEPG 1259
            ::.:||.||||..|.|.:.|:.:|::          :.|.|...::....|...:|.|.:.|:..
  Fly  1035 VIFATHFMDEAKYLSDSLVIMRNGRIIAQHSRDSLQRLCTSNYSIRLRCADATGVTFVIQKAQQL 1099

Human  1260 GPQ----EPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFE 1320
            .||    ..|.|..|         ..|.::....:|:.                      .||.|
  Fly  1100 LPQTQVTHSGAADYP---------HSLTINASYAEHLT----------------------PGAVE 1133

Human  1321 RLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDVLPGAEGPASGEG 1385
                                        ||::. :.|....|.:||                   
  Fly  1134 ----------------------------FLELL-QSQVTAGSISDV------------------- 1150

Human  1386 HAGNLARCSELTQSQASLQSASSVGSARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEAL 1450
                     |||.|.:..|....:.  |..|.||              |:.|         |...
  Fly  1151 ---------ELTTSSSLEQEFEQLN--RNGEDAG--------------PRRP---------ASDR 1181

Human  1451 SRVGQGSRKL-DGGWLKVRQFHGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGD 1514
            |.|..|...: |......:||..|:.||.....||.:.|...:||||.|...||.          
  Fly  1182 SGVVAGPAMITDEPPTACKQFRLLMGKRLRHLSRNYRLLLYVLLLPALFELCAMW---------- 1236

Human  1515 LPPLVLSPSQYHNYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPA 1579
                                |:.|..|:..:..|.||....||                      
  Fly  1237 --------------------FVSYRLEDDFDTVLPLSRSLYPQ---------------------- 1259

Human  1580 NGSLGPTLNLSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNV 1644
                              .|:|.......||::.|                              
  Fly  1260 ------------------TAQFLSHERATSFSEKL------------------------------ 1276

Human  1645 SLPPTAGPEMWTSAPSLPRLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNV 1709
                            .|:|     |.:|.              |..:.||..       |....
  Fly  1277 ----------------YPQL-----RTSCD--------------HLGECRVFN-------TSQQS 1299

Human  1710 SEYLLFTSDRFRLHRYGAITFGNVLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGYHSMPTYL 1774
            .:::|.:...:...|||             .:|...          ..|.|:|||||||||..:|
  Fly  1300 YDWVLNSWGEYSERRYG-------------GYGLNG----------SGATVWYNNKGYHSMMAWL 1341

Human  1775 NSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLL-QGTDVVIAIFIIVAMSFVPA 1838
            |.||:.:||..:     |.:...|...|.|.....|.||...:| |..|..:...:::|...|.|
  Fly  1342 NDLNSELLRTTM-----NDSESSILTLNEPWKLGFAELSTSSILRQAGDGSMVFILLIAFGLVVA 1401

Human  1839 SFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNF 1903
            |..|:||.|:....|..|.:.|.:.:.|||...|||.|..::....|::::.:|.:|.:......
  Fly  1402 SGSVYLVNERVNGEKLQQRLCGVSAVTYWLVALVWDYLVMVLGLIVCLVVILMFGMPVFVDRQQL 1466

Human  1904 PAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVV 1968
            ..::.|.|.:.::..|.::.|...|...|.|.|.:...||.:.: .|:...|:        |.||
  Fly  1467 VGIIGLSLAFSFACVPSVHVAEKIFSDSSIAIVSIFCANLIVPL-VTMGIILI--------LGVV 1522

Human  1969 NS---------YLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLV 2024
            ..         .|...|||||.:.||.|.:|:..|..:...:.:. ..|..|.|...|::.|...
  Fly  1523 GDGPAWDDWRHALNQAFLIFPIHALGDGFLELCKNYMVALVFRRY-DIDSYKHPLASDLLGRHFT 1586

Human  2025 AMAVEGVVGFLLTIMCQYNFLRRP-QRMPVSTKPVEDDVDVASER-------------QRVLRGD 2075
            |:.:.||...::.::.:::.|||. ||       ||..:|....|             |.:.:..
  Fly  1587 ALLLVGVAALIINVLIEWHLLRRLWQR-------VERLLDCTYRRELDKLGQLKLVNIQSIFKSC 1644

Human  2076 AD-NDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTG 2139
            .| .:.|:.|||...|:...    .||..:...|:.||||||||.|||||::.||:|||......
  Fly  1645 VDTGEAVRAENLWLAYRRGH----YAVRNVNFSVQRGECFGLLGKNGAGKSTIFKLLTGQLQPDV 1705

Human  2140 GEAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKL 2204
            |:.:..           |..:.||||.:.|...||..|.::.|.|||||  :|..:.:...|:..
  Fly  1706 GQIYFE-----------QPGISYCPQSNPLDPLLTTTECIRFYGRLRGI--RDLDQFLDRVLDTY 1757

Human  2205 ELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSV 2269
            ||..|.|......||||:|||:.|:...|....:.:||||:.|||..|..::..|..|:...|:|
  Fly  1758 ELRPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMDEPTSDMDPVTRDMVYATIEQLLLARRAV 1822

Human  2270 VLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFNRNF 2334
            ||||||:.|.|.||.|:|::..|::....|.|.||:..|..|.:|.....:|.. .:.|..|:..
  Fly  1823 VLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLKSEHGGYYAVTCFCGPAQQA-ILSRSLNQRL 1886

Human  2335 PEAMLKERHHTKVQYQLK-------SEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFA 2392
            |.|...:.:...:::.::       .:...|:::|:.:..|  .:.:..:|:|:...:.||....
  Fly  1887 PGARDLQHYAHSLRFLVRVRSPGSLGDAPLLSELFAILCDV--CVNVARFSLSRCRFETVFERIL 1949

Human  2393 KKQSDN------LEQQETEPPSALQS 2412
            .....|      .:||:....:.|.|
  Fly  1950 DSSESNGSNGVHKDQQQQVAKNDLPS 1975

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCA2NP_997698.1 rim_protein 58..2398 CDD:130324 490/2214 (22%)
lddNP_001285513.1 rim_protein 179..1867 CDD:130324 477/2123 (22%)

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