Protein Alignment A2M and Tep2

DIOPT Version :10

• Sequence 1: XP_006719119.1
• Gene: A2M / 2
• HGNCID: 7
• Length: 1512
• Species: Homo sapiens
• Sequence 2: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Alignment Length: 1563
• Identity: 438/1563 - (28%)
• Similarity: 684/1563 - (43%)
• Gaps: 254/1563 - (16%)

Human    12 VLLLLVLLPTDASVSGKPQYMVLVPSLLHTETTEKGCVLLSYLNETVTVSASLESVRGNRSLFTD 76
            :.|..::|.....|:....|.|:.|..|.:.:.....|.:...:....:..||.....|.:...:
  Fly     4 IFLTGIILQYALLVNATGIYSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSYNETKQIE 68

Human    77 L---EAENDVLHCVAFAVPKSSSNEEVMFLTVQVKGPT-QEFKKRTTVMVKNEDSLVFVQTDKSI 137
            |   ..:|     |.|.|||.::..    ..:..:|.: ..||..|.:...::...|||||||:.
  Fly    69 LPPMSTQN-----VEFEVPKLATGN----YNLSAEGVSGVVFKNSTKLNYADKKPSVFVQTDKAT 124

Human   138 YKPGQTVKFRVVSMDENFHPLNELIPL-VYIQDPKGNRIAQWQSFQLEGGLKQFSFPLSSEPFQG 201
            |||...|:||::.:|||..|.....|: |.|.|...|||.|....:|..|:......||.:|..|
  Fly   125 YKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVLG 189

Human   202 SYKVVVQKKSGGRTEHPFTVEEFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPGHVTV 266
            ::|:.|......|....|.|:::|||||||.|..||.:.|.::.:..::...|||||||.|..||
  Fly   190 TWKISVSVDGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPVKGKATV 254

Human   267 SICRKYSDASDCHGEDSQAFCEKFSGQLNSHGCFYQQVKT------------KVFQLKRKEYEMK 319
            |:.|.|.                :.|.||::|  .:|.||            .:...:|.:|...
  Fly   255 SMERSYG----------------YFGDLNANG--NKQEKTIDVDGKGHVEFDIIHWAQRGQYLPP 301

Human   320 LHTEAQIQEEGTVVELTGRQSSEITRTITKLSFVKVD-----SHFRQGIPFFGQVRLVDGKGVPI 379
            :...|.:.|     ||||.:.:.....:.......::     .||.....|..||.:.:..|.|:
  Fly   302 IKLFAVVTE-----ELTGNKQNATATVVLHQQRYSIEPYERPEHFEANKSFIYQVVVKNVDGSPV 361

Human   380 PNKVIFIRGNEANYYS-------------NATTDEHGLVQFSINTTNVMGTSLTVRVNYKDRSPC 431
            .|....::......||             .|..:|:|:..|:              |...|....
  Fly   362 TNSAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIATFN--------------VRLPDSDSR 412

Human   432 YGYQWVSEEHEEAHHTAYLVFSPSKSFVHLEPMSHELPCGHTQTVQAHYILNGGTLLGLKKLS-- 494
            |...:.|.:..|....:...|.|:       |||.|.......|.:...    |..:....:|
  Fly   413 YYRIFASFDGSENTIGSISKFEPT-------PMSREPLKIQVNTKKPRL----GEQVSFDVVSIE 466

Human   495 ----FYYLIMAKGGIVRTGTHGLLVKQEDMKGHFSISIPVKSDIAPVARLLIYAVLPTGDVIGDS 555
                |.|.|:|:|.::.:.    .|...|.:..:::.......:.|.|.:.:|.|: ..|:..:.
  Fly   467 DLPYFVYTIVARGNVILSD----YVDVPDGQKTYTVKFTPTFSMVPKATIYVYYVV-NNDLQFEE 526

Human   556 AKYDVENCLANKVDLSFSPSQSLPASHAHLRVTAAPQSVCALRAVDQSVLLMKPDAELSASSVYN 620
            ...|.|...:|.:|:| :|:.:.|:....||:.....|...|..|||||||:|...:||...::|
  Fly   527 KTIDFEKEFSNSIDVS-APTNAKPSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFN 590

Human   621 LLPEKDLTGFPGPLNDQDNEDCINRHNVY------INGITYTP------VSSTNEKDMYSFLEDM 673
            .|                        |:|      :||....|      |:.||....|:....:
  Fly   591 SL------------------------NIYQTSTPWMNGYGRYPGQTSGLVTLTNANYPYNTGPLV 631

Human   674 GLKAFTNSK---IRKPKMCPQLQQYEMHGPEGLRVGFYESDVMGRGHARLVHVEEPHTETVRKYF 735
            ....|..|:   |.:|:     .:..:.|..|.|:.|....:..|....::..:.|...|:||.|
  Fly   632 MSYVFEGSRHPWITRPR-----YRVGIRGDSGDRISFLSQSLNDRNLKEILLKQTPQRTTIRKEF 691

Human   736 PETWIWDLVVVNSAGVAEVGVT--VPDTITEWKAGAFCLSEDAGLGISSTAS-LRAFQPFFVELT 797
            ||||.::     :.|..|..:|  :|||||.|....|.|:..:|:.::...| :|.||||||...
  Fly   692 PETWFFE-----NVGEEEFTLTKKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTN 751

Human   798 MPYSVIRGEAFTLKATVLNYLPKCIRVSVQL----------EASPAFLAVPVEKEQAPH--CICA 850
            :||||.|||...:...:.|||.|.:...|.:          ||:...|...:::.:...  .|.|
  Fly   752 LPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPA 816

Human   851 NGRQTVSWAVTPKSLGNVNFTVSAEALESQELCGTEVPSVPEHGRKDTVIKPLLVEPEGL---EK 912
            |..::||:.:.||::|.....::|    :..|.|            |.:.:.|.|||||:   |.
  Fly   817 NSGKSVSFMIRPKNVGFTTLKITA----TSALAG------------DAIHQKLKVEPEGVTLFEN 865

Human   913 ETTFNSLLCPSGGEVSEELSLKLPPNVVEESARASVSVLGDILGSAMQNTQNLLQMPYGCGEQNM 977
            ...|.:|  ....|:|:.|...:|..||.:|.....||:||:||..:||..||::||||||||||
  Fly   866 RAVFINL--KDQPEMSQSLDADIPNEVVPQSEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGEQNM 928

Human   978 VLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGERYGRNQGNTWLT 1042
            |.|.|||.||.||..|.:..|.::|||..:|..||||:|.|||.|||||.||:  ....|:||||
  Fly   929 VNFVPNILVLKYLEVTGRKLPSVESKARKFLEIGYQRELTYKHDDGSYSAFGK--SDASGSTWLT 991

Human  1043 AFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITI 1107
            |:|:::|.||..|..||...||..|.:|..:||::|.|...|.|.:||    .::.:.|::::.:
  Fly   992 AYVMRSFHQAGTYTDIDPKVITAGLDFLVSKQKESGEFPEVGKLFDNA----NQNPLALTSFVLL 1052

Human  1108 ALLEIPLTVTHPVVRNALFCLESAWK-TAQEGDHGSHVYTKALLAYAFALAGNQDKRKEVLKSLN 1171
            |..|     .|.::......::.|.: .|:|.|.....|:.|:.|.|..||.:....| |:..|.
  Fly  1053 AFFE-----NHELIPKYQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQLAKHPQSEK-VIAKLE 1111

Human  1172 EEAVKKDNSVHWERPQKPKAPVGHFYEPQAPSAEVEMTSYVLLAYLTAQPAPTSEDLTSATNIVK 1236
            ..|.|:::.:.|.:..:.....|..:..:..|.:||:|||||||.|...||      ..|..|:|
  Fly  1112 SVARKENDRMWWSKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPA------EKALPIIK 1170

Human  1237 WITKQQNAQGGFSSTQDTVVALHALSKYGAATFTRTGKAAQVTIQSSGTFSSKFQVDNNNRLLLQ 1301
            |:..|:|:.||||||||||:.|.||:|:...|.:.:| ...:...|:|...:..:|:..|.|:||
  Fly  1171 WLISQRNSNGGFSSTQDTVIGLQALTKFAYKTGSGSG-TMDIEFSSAGESKNTIKVNPENSLVLQ 1234

Human  1302 QVSLPELPGEYSMKVTGEGCVYLQTSLKYNILPEKEEFPFALGVQTLPQTCDEPKAHTSFQISLS 1366
            ...||:...:......|.|...:|.|.:|| |.|||:.|   ..:..|...|.|  :....:.:.
  Fly  1235 THDLPKSTRKVDFTAKGTGSAMVQLSYRYN-LAEKEKKP---SFKVTPTVKDTP--NQLLIVDVC 1293

Human  1367 VSYTGSRSA-----SNMAIVDVKMVSGFIPLKPTVKMLERSNHVSRTEVSSNHVLIYLDKVSNQT 1426
            ..|.....|     ||||::::.:.|||:....::..::..:.|.|.|.          |.|:.|
  Fly  1294 AEYVPLEDADKDKDSNMAVMEIALPSGFVGDSTSLGKIQAVDRVKRVET----------KNSDST 1348

Human  1427 LSLFFTVLQDVPVRDL-------------KPAIVKVYDYYETDEFAIAEY-----------NAPC 1467
            :.::|..|....||.|             |||.|.:||||:|:..|...|           .|.|
  Fly  1349 VVVYFDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVKSSLCDICEGADC 1413

Human  1468 SKG 1470
            .:|
  Fly  1414 GEG 1416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
A2M	XP_006719119.1	YfaS	<129..1338	CDD:441940	377/1279 (29%)
		A2M	738..828	CDD:459711	34/92 (37%)
		A2M_2	958..1264	CDD:239227	122/306 (40%)
		A2M_recep	1374..1464	CDD:462226	30/118 (25%)
Tep2	NP_523506.1	YfaS	<72..1395	CDD:441940	421/1472 (29%)
		A2M_2	909..1198	CDD:239227	122/306 (40%)