DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment A2M and Tep2

DIOPT Version :9

Sequence 1:XP_006719119.1 Gene:A2M / 2 HGNCID:7 Length:1512 Species:Homo sapiens
Sequence 2:NP_523506.1 Gene:Tep2 / 34044 FlyBaseID:FBgn0041182 Length:1420 Species:Drosophila melanogaster


Alignment Length:1563 Identity:438/1563 - (28%)
Similarity:684/1563 - (43%) Gaps:254/1563 - (16%)


- Green bases have known domain annotations that are detailed below.


Human    12 VLLLLVLLPTDASVSGKPQYMVLVPSLLHTETTEKGCVLLSYLNETVTVSASLESVRGNRSLFTD 76
            :.|..::|.....|:....|.|:.|..|.:.:.....|.:...:....:..||.....|.:...:
  Fly     4 IFLTGIILQYALLVNATGIYSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSYNETKQIE 68

Human    77 L---EAENDVLHCVAFAVPKSSSNEEVMFLTVQVKGPT-QEFKKRTTVMVKNEDSLVFVQTDKSI 137
            |   ..:|     |.|.|||.::..    ..:..:|.: ..||..|.:...::...|||||||:.
  Fly    69 LPPMSTQN-----VEFEVPKLATGN----YNLSAEGVSGVVFKNSTKLNYADKKPSVFVQTDKAT 124

Human   138 YKPGQTVKFRVVSMDENFHPLNELIPL-VYIQDPKGNRIAQWQSFQLEGGLKQFSFPLSSEPFQG 201
            |||...|:||::.:|||..|.....|: |.|.|...|||.|....:|..|:......||.:|..|
  Fly   125 YKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLSEQPVLG 189

Human   202 SYKVVVQKKSGGRTEHPFTVEEFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPGHVTV 266
            ::|:.|......|....|.|:::|||||||.|..||.:.|.::.:..::...|||||||.|..||
  Fly   190 TWKISVSVDGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRAKYTYGKPVKGKATV 254

Human   267 SICRKYSDASDCHGEDSQAFCEKFSGQLNSHGCFYQQVKT------------KVFQLKRKEYEMK 319
            |:.|.|.                :.|.||::|  .:|.||            .:...:|.:|...
  Fly   255 SMERSYG----------------YFGDLNANG--NKQEKTIDVDGKGHVEFDIIHWAQRGQYLPP 301

Human   320 LHTEAQIQEEGTVVELTGRQSSEITRTITKLSFVKVD-----SHFRQGIPFFGQVRLVDGKGVPI 379
            :...|.:.|     ||||.:.:.....:.......::     .||.....|..||.:.:..|.|:
  Fly   302 IKLFAVVTE-----ELTGNKQNATATVVLHQQRYSIEPYERPEHFEANKSFIYQVVVKNVDGSPV 361

Human   380 PNKVIFIRGNEANYYS-------------NATTDEHGLVQFSINTTNVMGTSLTVRVNYKDRSPC 431
            .|....::......||             .|..:|:|:..|:              |...|....
  Fly   362 TNSAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIATFN--------------VRLPDSDSR 412

Human   432 YGYQWVSEEHEEAHHTAYLVFSPSKSFVHLEPMSHELPCGHTQTVQAHYILNGGTLLGLKKLS-- 494
            |...:.|.:..|....:...|.|:       |||.|.......|.:...    |..:....:|  
  Fly   413 YYRIFASFDGSENTIGSISKFEPT-------PMSREPLKIQVNTKKPRL----GEQVSFDVVSIE 466

Human   495 ----FYYLIMAKGGIVRTGTHGLLVKQEDMKGHFSISIPVKSDIAPVARLLIYAVLPTGDVIGDS 555
                |.|.|:|:|.::.:.    .|...|.:..:::.......:.|.|.:.:|.|: ..|:..:.
  Fly   467 DLPYFVYTIVARGNVILSD----YVDVPDGQKTYTVKFTPTFSMVPKATIYVYYVV-NNDLQFEE 526

Human   556 AKYDVENCLANKVDLSFSPSQSLPASHAHLRVTAAPQSVCALRAVDQSVLLMKPDAELSASSVYN 620
            ...|.|...:|.:|:| :|:.:.|:....||:.....|...|..|||||||:|...:||...::|
  Fly   527 KTIDFEKEFSNSIDVS-APTNAKPSEEVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFN 590

Human   621 LLPEKDLTGFPGPLNDQDNEDCINRHNVY------INGITYTP------VSSTNEKDMYSFLEDM 673
            .|                        |:|      :||....|      |:.||....|:....:
  Fly   591 SL------------------------NIYQTSTPWMNGYGRYPGQTSGLVTLTNANYPYNTGPLV 631

Human   674 GLKAFTNSK---IRKPKMCPQLQQYEMHGPEGLRVGFYESDVMGRGHARLVHVEEPHTETVRKYF 735
            ....|..|:   |.:|:     .:..:.|..|.|:.|....:..|....::..:.|...|:||.|
  Fly   632 MSYVFEGSRHPWITRPR-----YRVGIRGDSGDRISFLSQSLNDRNLKEILLKQTPQRTTIRKEF 691

Human   736 PETWIWDLVVVNSAGVAEVGVT--VPDTITEWKAGAFCLSEDAGLGISSTAS-LRAFQPFFVELT 797
            ||||.::     :.|..|..:|  :|||||.|....|.|:..:|:.::...| :|.||||||...
  Fly   692 PETWFFE-----NVGEEEFTLTKKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTN 751

Human   798 MPYSVIRGEAFTLKATVLNYLPKCIRVSVQL----------EASPAFLAVPVEKEQAPH--CICA 850
            :||||.|||...:...:.|||.|.:...|.:          ||:...|...:::.:...  .|.|
  Fly   752 LPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPA 816

Human   851 NGRQTVSWAVTPKSLGNVNFTVSAEALESQELCGTEVPSVPEHGRKDTVIKPLLVEPEGL---EK 912
            |..::||:.:.||::|.....::|    :..|.|            |.:.:.|.|||||:   |.
  Fly   817 NSGKSVSFMIRPKNVGFTTLKITA----TSALAG------------DAIHQKLKVEPEGVTLFEN 865

Human   913 ETTFNSLLCPSGGEVSEELSLKLPPNVVEESARASVSVLGDILGSAMQNTQNLLQMPYGCGEQNM 977
            ...|.:|  ....|:|:.|...:|..||.:|.....||:||:||..:||..||::||||||||||
  Fly   866 RAVFINL--KDQPEMSQSLDADIPNEVVPQSEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGEQNM 928

Human   978 VLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGERYGRNQGNTWLT 1042
            |.|.|||.||.||..|.:..|.::|||..:|..||||:|.|||.|||||.||:  ....|:||||
  Fly   929 VNFVPNILVLKYLEVTGRKLPSVESKARKFLEIGYQRELTYKHDDGSYSAFGK--SDASGSTWLT 991

Human  1043 AFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITI 1107
            |:|:::|.||..|..||...||..|.:|..:||::|.|...|.|.:||    .::.:.|::::.:
  Fly   992 AYVMRSFHQAGTYTDIDPKVITAGLDFLVSKQKESGEFPEVGKLFDNA----NQNPLALTSFVLL 1052

Human  1108 ALLEIPLTVTHPVVRNALFCLESAWK-TAQEGDHGSHVYTKALLAYAFALAGNQDKRKEVLKSLN 1171
            |..|     .|.::......::.|.: .|:|.|.....|:.|:.|.|..||.:....| |:..|.
  Fly  1053 AFFE-----NHELIPKYQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQLAKHPQSEK-VIAKLE 1111

Human  1172 EEAVKKDNSVHWERPQKPKAPVGHFYEPQAPSAEVEMTSYVLLAYLTAQPAPTSEDLTSATNIVK 1236
            ..|.|:::.:.|.:..:.....|..:..:..|.:||:|||||||.|...||      ..|..|:|
  Fly  1112 SVARKENDRMWWSKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPA------EKALPIIK 1170

Human  1237 WITKQQNAQGGFSSTQDTVVALHALSKYGAATFTRTGKAAQVTIQSSGTFSSKFQVDNNNRLLLQ 1301
            |:..|:|:.||||||||||:.|.||:|:...|.:.:| ...:...|:|...:..:|:..|.|:||
  Fly  1171 WLISQRNSNGGFSSTQDTVIGLQALTKFAYKTGSGSG-TMDIEFSSAGESKNTIKVNPENSLVLQ 1234

Human  1302 QVSLPELPGEYSMKVTGEGCVYLQTSLKYNILPEKEEFPFALGVQTLPQTCDEPKAHTSFQISLS 1366
            ...||:...:......|.|...:|.|.:|| |.|||:.|   ..:..|...|.|  :....:.:.
  Fly  1235 THDLPKSTRKVDFTAKGTGSAMVQLSYRYN-LAEKEKKP---SFKVTPTVKDTP--NQLLIVDVC 1293

Human  1367 VSYTGSRSA-----SNMAIVDVKMVSGFIPLKPTVKMLERSNHVSRTEVSSNHVLIYLDKVSNQT 1426
            ..|.....|     ||||::::.:.|||:....::..::..:.|.|.|.          |.|:.|
  Fly  1294 AEYVPLEDADKDKDSNMAVMEIALPSGFVGDSTSLGKIQAVDRVKRVET----------KNSDST 1348

Human  1427 LSLFFTVLQDVPVRDL-------------KPAIVKVYDYYETDEFAIAEY-----------NAPC 1467
            :.::|..|....||.|             |||.|.:||||:|:..|...|           .|.|
  Fly  1349 VVVYFDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVKSSLCDICEGADC 1413

Human  1468 SKG 1470
            .:|
  Fly  1414 GEG 1416

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
A2MXP_006719119.1 YfaS <124..>1071 CDD:225248 294/1016 (29%)
A2M_N 129..221 CDD:280081 35/92 (38%)
A2M_N_2 461..606 CDD:285005 35/150 (23%)
A2M 738..828 CDD:278630 34/92 (37%)
A2M_2 958..1264 CDD:239227 122/306 (40%)
A2M_comp 1010..1266 CDD:284982 94/256 (37%)
A2M_recep 1376..1463 CDD:284981 28/99 (28%)
Tep2NP_523506.1 A2M_N 115..209 CDD:280081 35/93 (38%)
A2M_N_2 445..576 CDD:285005 31/140 (22%)
A2M 694..782 CDD:278630 34/92 (37%)
A2M_2 909..1198 CDD:239227 122/306 (40%)
A2M_comp 961..1199 CDD:284982 94/255 (37%)
A2M_recep 1308..1398 CDD:284981 28/99 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149968
Domainoid 1 1.000 84 1.000 Domainoid score I8230
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100452
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X292
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.650

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