Protein Alignment ARY and akr1b1.2

DIOPT Version :10

• Sequence 1: NP_001163844.1
• Gene: ARY / 19988923
• FlyBaseID: FBgn0058064
• Length: 384
• Species: Drosophila melanogaster
• Sequence 2: NP_001070715.1
• Gene: akr1b1.2 / 553452
• ZFINID: ZDB-GENE-041210-132
• Length: 316
• Species: Danio rerio
• Alignment Length: 315
• Identity: 124/315 - (39%)
• Similarity: 183/315 - (58%)
• Gaps: 10/315 - (3%)

  Fly    37 MAPKVRLSSGHEMPVLGFGTYKLRGYQCSAAVHCAIETGFRHFDTAYYYENEKEIGEALRTQIKM 101
            |:..|:|::|.:||:||.||:|....:.:.||..||..|:||.|.|..|.||.|:||.::..||.
Zfish     1 MSKSVKLNTGADMPILGLGTWKSPPGKVAEAVKAAIAAGYRHIDGAAVYNNETEVGEGIKAMIKD 65

  Fly   102 GNISRENIFLTTKLWNTHHDPRDVRRICEKQLELLGFSYIDLYLMHFPVGYKYVCDEILMPMSGD 166
            |.:.||.:|:.:|||.|.|:...|:..|:|.|..|...|:||||:|:|:|:|...::  .|:..:
Zfish    66 GVVKREELFVVSKLWCTFHEKALVKGACQKTLSDLNLDYLDLYLIHWPMGFKSGSEQ--FPLDSE 128

  Fly   167 ELQTVEID--YLDTWRAMENLVKLGMVRSIGLSNFNMEQIQRIIQCS--SSKPVVNQVEIWPGFL 227
            .| |:..|  :||||..||.||..|:|::||:||||.|||:.|:...  ..||..||||..|...
Zfish   129 GL-TIGDDSSFLDTWEGMEELVDAGLVKAIGISNFNREQIEAILNKPGLKYKPANNQVECHPYLT 192

  Fly   228 QKDLVDYCRYNGIIVTAFSPLGQPNR---KNHCPVYFFSEGMKRLVKKYKRSASQIVLRYLIDYG 289
            |..|:.||:..||.|||:||||.|:|   |...|.......:|.:.:|:|::.:|:::|:.|...
Zfish   193 QDKLISYCQSKGITVTAYSPLGSPDRPWAKPEDPSLLDDPNIKAIAEKHKKTTAQVLIRFQIQRN 257

  Fly   290 VVPIPKAANPIHIKENLNIFDFKLDEADTRLLRGIKPKSRIVKYEIVKDHMFYPF 344
            |:.|||:..|..|:||..:|||:|.|.|.:.:.......|.........|..|||
Zfish   258 VIVIPKSITPQRIQENFQVFDFELSEEDMKTILSFNRNFRACPMHWGVKHRDYPF 312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARY	NP_001163844.1	AKR_AKR2E1-5	39..331	CDD:381342	119/298 (40%)
akr1b1.2	NP_001070715.1	AKR_SF	10..316	CDD:444925	121/306 (40%)