Protein Alignment ARY and AKR1C4

DIOPT Version :10

• Sequence 1: NP_001163844.1
• Gene: ARY / 19988923
• FlyBaseID: FBgn0058064
• Length: 384
• Species: Drosophila melanogaster
• Sequence 2: NP_001809.4
• Gene: AKR1C4 / 1109
• HGNCID: 387
• Length: 323
• Species: Homo sapiens
• Alignment Length: 323
• Identity: 128/323 - (39%)
• Similarity: 179/323 - (55%)
• Gaps: 19/323 - (5%)

  Fly    37 MAPK---VRLSSGHEMPVLGFGTYKLRGYQCSAAVH---CAIETGFRHFDTAYYYENEKEIGEAL 95
            |.||   |.|:.||.|||||||||.......:.||.   .|||.||||.|:||.|.||:::|.|:
Human     1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAI 65

  Fly    96 RTQIKMGNISRENIFLTTKLWNTHHDPRDVRRICEKQLELLGFSYIDLYLMHFPVGYKYVCDEIL 160
            |::|..|::.||:||.|:|||.|...|:.|:...|..|:.|...|:||||:|||:..|    ...
Human    66 RSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALK----PGE 126

  Fly   161 MPMSGDELQTVEIDYLD---TWRAMENLVKLGMVRSIGLSNFNMEQIQRIIQCS--SSKPVVNQV 220
            .|:..||...|..|.:|   ||..||.....|:.:|||:||||..|::.|:...  ..|||.|||
Human   127 TPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQV 191

  Fly   221 EIWPGFLQKDLVDYCRYNGIIVTAFSPLGQPNRK----NHCPVYFFSEGMKRLVKKYKRSASQIV 281
            |..|...|..|:|:|:...|::.|.|.||....|    .:.||......:..|.||:|::.:.|.
Human   192 ECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHKQTPALIA 256

  Fly   282 LRYLIDYGVVPIPKAANPIHIKENLNIFDFKLDEADTRLLRGIKPKSRIVKYEIVKDHMFYPF 344
            |||.:..|||.:.|:.|...|:||:.:|:|:|...|.::|.|:....|.|..:.:.||..|||
Human   257 LRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVVMDFLMDHPDYPF 319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARY	NP_001163844.1	AKR_AKR2E1-5	39..331	CDD:381342	121/306 (40%)
AKR1C4	NP_001809.4	AKR_AKR1C1-35	6..306	CDD:381334	119/303 (39%)