DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ELAVL4 and spen

DIOPT Version :9

Sequence 1:	XP_011539191.1	Gene:	ELAVL4 / 1996	HGNCID:	3315	Length:	416	Species:	Homo sapiens
Sequence 2:	NP_722615.1	Gene:	spen / 44205	FlyBaseID:	FBgn0016977	Length:	5560	Species:	Drosophila melanogaster

Alignment Length:	274	Identity:	52/274 - (18%)
Similarity:	107/274 - (39%)	Gaps:	71/274 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    80 SKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSL-GYGFVNYIDPKDAEKAINTL 143
            |...|.:..|.:::|..|.||.|.:.|||     :...|..|.| .|.|..|.|.....||:..:
  Fly   654 STRTLFIGNLEKDITAGELRSHFEAFGEI-----IEIDIKKQGLNAYAFCQYSDIVSVVKAMRKM 713

Human   144 NGLRLQTKTIKVSYAR--PSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTG 206
            :|..|.:..||:.:.:  |::.      :::.|:.:.:::..|:..|:::|.:  :::.:|:
  Fly   714 DGEHLGSNRIKLGFGKSMPTNC------VWIDGVDEKVSESFLQSQFTRFGAV--TKVSIDR--- 767

Human   207 VSRGVGFIRFDKRIEAEEAIKGLNG----------------------------QKPSGATEPITV 243
             :|.:..:.:|:...|:.|:|.:.|                            |:.|..:.|...
  Fly   768 -NRQLALVLYDQVQNAQAAVKDMRGTILRRKKLQVDFASRECQDAFYDKQEKQQQQSSGSNPRFS 831

Human   244 KFANNPSQKSSQALLSQLYQSPNR--------RYPG----------PLHHQAQRFRLDNLLNMAY 290
            ::.::.|...|::..|...:..|.        ..||          .|.:|:....:.|:
  Fly   832 RYESSASSLQSRSRASSFSRHQNNSNDDCSPINTPGGASSGISSASNLINQSTSINISNI----- 891

Human   291 GVKRLMSGPVPPSA 304
            |.....:.|.|..|
  Fly   892 GTNACSAMPAPSLA 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ELAVL4	XP_011539191.1	ELAV_HUD_SF	79..415	CDD:273741	52/274 (19%)
spen	NP_722615.1	RRM2_SHARP	555..628	CDD:240795
		RRM3_SHARP	654..726	CDD:240796	24/76 (32%)
		RRM4_SHARP	727..803	CDD:240797	12/87 (14%)
		RILP-like	1997..>2055	CDD:304877
		SPOC	5404..5527	CDD:285043
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910