DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ELAVL1 and elavl1a

DIOPT Version :9

Sequence 1:	NP_001410.2	Gene:	ELAVL1 / 1994	HGNCID:	3312	Length:	326	Species:	Homo sapiens
Sequence 2:	XP_005171324.1	Gene:	elavl1a / 30736	ZFINID:	ZDB-GENE-990415-245	Length:	340	Species:	Danio rerio

Alignment Length:	326	Identity:	277/326 - (84%)
Similarity:	302/326 - (92%)	Gaps:	2/326 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSNGYEDHMAEDCRGDIGRTNLIVNYLPQNMTQDELRSLFSSIGEVESAKLIRDKVAGHSLGYGF 65
            ||||||||||::...  .:||||||||||||:|||||||||||||||||||||||||||||||||
Zfish    17 MSNGYEDHMADELID--SKTNLIVNYLPQNMSQDELRSLFSSIGEVESAKLIRDKVAGHSLGYGF 79

Human    66 VNYVTAKDAERAINTLNGLRLQSKTIKVSYARPSSEVIKDANLYISGLPRTMTQKDVEDMFSRFG 130
            |||:...||||||:|||||||||||||||||||||:.||||||||||||:||||||||:||.|:|
Zfish    80 VNYLNPNDAERAISTLNGLRLQSKTIKVSYARPSSDSIKDANLYISGLPKTMTQKDVEEMFGRYG 144

Human   131 RIINSRVLVDQTTGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPITVKFAANPNQNKNVAL 195
            |||||||||||.:||||||||||||||:|||:||...||.||||::|.:||||||:|||.||..:
Zfish   145 RIINSRVLVDQASGLSRGVAFIRFDKRAEAEDAIKDLNGQKPPGAAEQMTVKFAASPNQVKNTQV 209

Human   196 LSQLYHSPARRFGGPVHHQAQRFRFSPMGVDHMSGLSGVNVPGNASSGWCIFIYNLGQDADEGIL 260
            :.|:||..:|||||||||||||||||||.||||||:||||||||:||||||||||||||||||||
Zfish   210 IPQVYHQQSRRFGGPVHHQAQRFRFSPMSVDHMSGMSGVNVPGNSSSGWCIFIYNLGQDADEGIL 274

Human   261 WQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKILQVSFKTNKSH 325
            |||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||:|||
Zfish   275 WQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTHYEEAAMAIASLNGYRLGDKILQVSFKTSKSH 339

Human   326 K 326
            |
Zfish   340 K 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ELAVL1	NP_001410.2	ELAV_HUD_SF	19..326	CDD:273741	265/306 (87%)
elavl1a	XP_005171324.1	ELAV_HUD_SF	31..340	CDD:273741	265/310 (85%)
		RRM1_Hu	33..110	CDD:241094	69/76 (91%)
		RRM2_HuR	120..203	CDD:241217	65/82 (79%)
		RRM3_HuR	257..340	CDD:241097	80/82 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194338846
Domainoid	1	1.000	145	1.000	Domainoid score	I18535
eggNOG	1	0.900	-	-		E1_KOG0145
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	564	1.000	Inparanoid score	I5693
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG55893
OrthoDB	1	1.010	-	-		D220572at7742
OrthoFinder	1	1.000	-	-		FOG0000313
OrthoInspector	1	1.000	-	-		otm27912
orthoMCL	1	0.900	-	-		OOG6_113949
Panther	1	1.100	-	-	LDO	PTHR10352
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8898
SonicParanoid	1	1.000	-	-		X326
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300