DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ELAVL2 and elavl2

DIOPT Version :9

Sequence 1:	XP_011516080.2	Gene:	ELAVL2 / 1993	HGNCID:	3313	Length:	392	Species:	Homo sapiens
Sequence 2:	NP_001002172.2	Gene:	elavl2 / 431719	ZFINID:	ZDB-GENE-040704-9	Length:	389	Species:	Danio rerio

Alignment Length:	388	Identity:	340/388 - (87%)
Similarity:	365/388 - (94%)	Gaps:	5/388 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     7 LYDIVHAKLPGKSSWRT-VFKGQVIAAMETQLSNGPTCNNTANGPTTINNNCSSPVDSGN-TEDS 69
            |.|:  |.|....||.. .:.|||||||||||||||:| .::|||.:::|.|:|||:..| :|||
Zfish     5 LCDV--ASLLRSGSWAAEPWTGQVIAAMETQLSNGPSC-TSSNGPNSVSNTCTSPVEMPNGSEDS 66

Human    70 KTNLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNG 134
            ||||||||||||||||||||||||||||||||||||||||||||||||||::|||||||||||||
Zfish    67 KTNLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYMEPKDAEKAINTLNG 131

Human   135 LRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGISRG 199
            |||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||:|||
Zfish   132 LRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQFGRIITSRILVDQVTGVSRG 196

Human   200 VGFIRFDKRIEAEEAIKGLNGQKPPGATEPITVKFANNPSQKTNQAILSQLYQSPNRRYPGPLAQ 264
            |||||||:|:||||||||||||||||||||||||||||||||::||:||.|||||||||||||||
Zfish   197 VGFIRFDRRVEAEEAIKGLNGQKPPGATEPITVKFANNPSQKSSQALLSHLYQSPNRRYPGPLAQ 261

Human   265 QAQRFRLDNLLNMAYGVKSRFSPMTIDGMTSLAGINIPGHPGTGWCIFVYNLAPDADESILWQMF 329
            ||||||||||||||||||||||||||||:|||||||:|.|.|||||||||||||||||::|||||
Zfish   262 QAQRFRLDNLLNMAYGVKSRFSPMTIDGVTSLAGINLPAHAGTGWCIFVYNLAPDADENVLWQMF 326

Human   330 GPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKTHKA 392
            |||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||
Zfish   327 GPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYDEAAVAIASLNGYRLGDRVLQVSFKTNKTHKA 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ELAVL2	XP_011516080.2	None
elavl2	NP_001002172.2	ELAV_HUD_SF	65..388	CDD:273741	305/322 (95%)
		RRM1_Hu	67..144	CDD:241094	74/76 (97%)
		RRM2_HuB	149..238	CDD:241219	84/88 (95%)
		RRM_SF	303..388	CDD:302621	81/84 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194342300
Domainoid	1	1.000	159	1.000	Domainoid score	I16743
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20930
Inparanoid	1	1.050	660	1.000	Inparanoid score	I4679
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG55893
OrthoDB	1	1.010	-	-		D220572at7742
OrthoFinder	1	1.000	-	-		FOG0000313
OrthoInspector	1	1.000	-	-		oto52043
orthoMCL	1	0.900	-	-		OOG6_103306
Panther	1	1.100	-	-	LDO	PTHR10352
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3804
SonicParanoid	1	1.000	-	-		X326
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	17	17.440