DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERPINB1 and Spn88Eb

DIOPT Version :9

Sequence 1:	NP_109591.1	Gene:	SERPINB1 / 1992	HGNCID:	3311	Length:	379	Species:	Homo sapiens
Sequence 2:	NP_650427.1	Gene:	Spn88Eb / 41829	FlyBaseID:	FBgn0038299	Length:	426	Species:	Drosophila melanogaster

Alignment Length:	410	Identity:	110/410 - (26%)
Similarity:	197/410 - (48%)	Gaps:	54/410 - (13%)

- Green bases have known domain annotations that are detailed below.

Human     3 QLSSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHFN------ 61
            |:......|:|.|...:.|..|:||:|.||||..:|:.:.:..:...|..:|::..:..
  Fly    33 QIFKGERDFSLALMKQIREIYPSGNLFFSPFSTYNALLLAYFSSSEQTERELAQALNLGWALNKQ 97

Human    62 ------TVEEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVD 120
                  |:.:....|:       .|.:...|..|||::.::|.|...:|   ....||| ...:|
  Fly    98 QVLVSYTLAQRQDEFR-------WRQSPMELSSANRIFVDRTINVSNKF---NTLLYGA-TKELD 151

Human   121 FQHASEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPF 185
            |::..|...|.||.|:..:|..:|.::|:|..:...|.|||.||.|.||.|..:|..|.|...||
  Fly   152 FKNDPETGLKEINDWIADKTHNQIRDMLSSEEITPHTMLVLANAAYMKGQWLSQFKVEETALKPF 216

Human   186 RLNKKDRKTVKMMYQKKKFAYGYIEDLKCRVLELPYQ---------------GEELSMVILLPDD 235
            .:|:::::.|.||::...|.....|.|:.::::|||:               ..::||:|:||:
  Fly   217 FINEREQEMVYMMHKTGAFKMTIDEGLQSQIIKLPYRTIYKSKETHISTPESKSDISMIIILPN- 280

Human   236 IEDESTGLKKIEEQLTLEKLHEWTK---PENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLF 297
              .....|.::..:|..:.:.:|.:   |:     ::.:|||:|:.|:...|...|:.:||..:|
  Fly   281 --SNKISLNRVISRLNADSVKKWFERALPQ-----KIELSLPKFQFEQRLELTPILSLMGVNTMF 338

Human   298 --NSSKADLSGMSGARDIFISKIVHKSFVEVNEEGTEAAAATAGIATFCMLMPE-ENFTADHPFL 359
              |::..||:  :....:.|....|.:.::|:|.|:.|||||..:.:.....|: ..|..:|||:
  Fly   339 TRNATFGDLT--ADPISLVIDDAQHLAKIKVDEVGSTAAAATILLVSRSSRQPDPTKFNCNHPFV 401

Human   360 FFIRHNSSGSILFLGRFSSP 379
            |.|......:|||.|.:|.|
  Fly   402 FLIYDEKVDTILFAGVYSDP 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERPINB1	NP_109591.1	SERPIN	4..379	CDD:294093	108/407 (27%)
SERPINB1	NP_109591.1	CARD-binding motif (CBM). /evidence=ECO:0000269\|PubMed:30692621	351..379		11/27 (41%)
Spn88Eb	NP_650427.1	SERPIN	37..418	CDD:238101	107/401 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920