Protein Alignment SERPINB1 and Spn47C

DIOPT Version :10

• Sequence 1: NP_109591.1
• Gene: SERPINB1 / 1992
• HGNCID: 3311
• Length: 379
• Species: Homo sapiens
• Sequence 2: NP_610633.1
• Gene: Spn47C / 36163
• FlyBaseID: FBgn0033574
• Length: 382
• Species: Drosophila melanogaster
• Alignment Length: 396
• Identity: 116/396 - (29%)
• Similarity: 205/396 - (51%)
• Gaps: 44/396 - (11%)

Human     4 LSSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQL-SKTF----HFNTV 63
            ||::...||.:||.||::..|..|:.:||....|||.:||:|..|.:|.:| ||..    :.:.|
  Fly    11 LSASPIVFARNLFRALNDEVPPVNMMVSPAGARSAMTLVFMGAGGKSADELRSKLILGVSNKSEV 75

Human    64 EEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDA 128
            .:.|:...:......|:|.:  |:|..|||..:......:|.....:.:.|:..|:::.: .||:
  Fly    76 AKQHAESWTDECSCAKKGVA--LRLVTRLYVNEEEKIRTDFNDMALEFFNAEAYSLNYLN-PEDS 137

Human   129 RKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRK 193
            .|.:|:|::..|...:..|....:.::.:.::|||:::|:..|...|.::.|....|.:|.:.|.
  Fly   138 VKKVNKWLEKHTFYTVRNLFTPEVFNSDSSVILVNSLFFRAKWNKIFPQQLTQIDDFWINPRQRM 202

Human   194 TVKMMYQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEW 258
            .|.||.|..:|.||..:.||.::|:||::...|:|:|:||..|:    ||.::||:|....::|.
  Fly   203 EVSMMRQIGQFRYGESKKLKSQILQLPFERSNLTMMIILPTAID----GLPELEEKLGQLDMNEV 263

Human   259 TKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADLSGMSGARDIF-------IS 316
            .....:.  ||:|::|:|::|.:..|...|.::|:..:|::.:||||      |:|       ||
  Fly   264 AAKSLMK--EVDVTIPKFRIECTVDLKVPLQKMGINSVFDAGQADLS------DLFEMKTPQKIS 320

Human   317 KIVHKSFVEVNEEGTEAAAATAGIATFCMLMPE--------ENFTADHPFLFFIRHNSSGSILFL 373
            :..||.|:.|.|.|.|       :|....:.||        :.|.||.||:|.||...  ::.|:
  Fly   321 EARHKVFLNVTEFGCE-------VAPEAEVQPEVLKKNPDRKFFKADRPFVFAIRDRK--NVYFV 376

Human   374 GRFSSP 379
            |.|..|
  Fly   377 GHFVKP 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINB1	NP_109591.1	serpinB1_LEI	1..379	CDD:381028	115/394 (29%)
		CARD-binding motif (CBM). /evidence=ECO:0000269|PubMed:30692621	351..379		11/27 (41%)
Spn47C	NP_610633.1	serpin42Dd-like_insects	13..382	CDD:381070	113/392 (29%)