DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ND5 and ND5

DIOPT Version :9

Sequence 1:	YP_009047273.1	Gene:	ND5 / 19893549	FlyBaseID:	FBgn0013684	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	YP_003024036.1	Gene:	ND5 / 4540	HGNCID:	7461	Length:	603	Species:	Homo sapiens

Alignment Length:	577	Identity:	206/577 - (35%)
Similarity:	328/577 - (56%)	Gaps:	29/577 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SMSLSCFLLSL-----YFLLNDMIYFIEWELVSLNSMSIVMTFLFDWMSLLFMSFVLMISSLVIF 70
            |:..|.|::||     :..|:..:....|...:..:..:.::|..|:.|::|:...|.::..::.
Human    38 SIVASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIME 102

  Fly    71 YSKEYMMNDNHINRFIMLVLMFVLSMMLLIISPNLISILLGWDGLGLVSYCLVIYFQNIKSYNAG 135
            :|..||.:|.:||:|...:|:|:::|::|:.:.||..:.:||:|:|::|:.|:.::......|..
Human   103 FSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARADANTA 167

  Fly   136 MLTA-LSNRIGDVALLLSIAW-MLNYGSWNYIFYLEIMQNEFEMLMIGSLVMLAAMTKSAQIPFS 198
            .:.| |.|||||:..:|::|| :|:..||:......:..|.....::|  ::|||..||||:...
Human   168 AIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLG--LLLAAAGKSAQLGLH 230

  Fly   199 SWLPAAMAAPTPVSALVHSSTLVTAGVYLLIRFNIILSTSWLGQ-LMLLLSGLTMFMAGLGANFE 262
            .|||:||..|||||||:||||:|.||::|||||:.:...|.|.| |.|.|..:|...|.:.|..:
Human   231 PWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQ 295

  Fly   263 FDLKKIIALSTLSQLGLMMSILSMGFLKLAMFHLLTHALFKALLFMCAGAIIHNMNNSQDIRLMG 327
            .|:|||:|.||.|||||||..:.:....||..|:.|||.|||:||||:|:||||:||.||||.||
Human   296 NDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMG 360

  Fly   328 GLSIHMPLTSACFNVSNLALCGMPFLAGFYSKDMILEIVSISNVNMFSFFLYYFSTGLTVSYSFR 392
            ||...|||||....:.:|||.|||||.||||||.|:|..::|..|.::..:...:|.||.:||.|
Human   361 GLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTSAYSTR 425

  Fly   393 LVYYSMTGDLNCGSLNMLNDESWIMLRGMMGLLIMSIIGGSMLNWLIFP-FPYMICLPIYMKLLT 456
            ::..::||.....:|..:|:.:..:|..:..|...|:..|.::...|.| .|:...:|:|:||..
Human   426 MILLTLTGQPRFPTLTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTA 490

  Fly   457 LFVCIVGGLFGYLISLSNLFFLNKSLFMYN-LSTFLGS--MWFMPYISTYGMIFY--PLNYGQLV 516
            |.|..:|     |::..:|.:|...|.|.: |.||..|  :.|.|.| |:..|.|  .|....|.
Human   491 LAVTFLG-----LLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSI-THRTIPYLGLLTSQNLP 549

  Fly   517 VKSFDQGWSEYFGGQHLYQ---KLSMYSKTLFLMHNNSLKIYLLLFVFWILILLILL 570
            :...|..|.|....:.:.|   ..|:.:.|    ....:|:|.|.|.|.:::.|:|:
Human   550 LLLLDLTWLEKLLPKTISQHQISTSIITST----QKGMIKLYFLSFFFPLILTLLLI 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ND5	YP_009047273.1	ND5	1..562	CDD:214444	203/567 (36%)
ND5	YP_003024036.1	ND5	16..594	CDD:177170	204/572 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159180
Domainoid	1	1.000	237	1.000	Domainoid score	I2330
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	327	1.000	Inparanoid score	I2477
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46593
OrthoDB	1	1.010	-	-		D365032at33208
OrthoFinder	1	1.000	-	-		FOG0004209
OrthoInspector	1	1.000	-	-		oto90727
orthoMCL	1	0.900	-	-		OOG6_101851
Panther	1	1.100	-	-	LDO	PTHR42829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2693
SonicParanoid	1	1.000	-	-		X2954
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.940